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Protein

Protein-L-isoaspartate O-methyltransferase

Gene

PCMT1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotation, Transferase
LigandS-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferaseUniRule annotation (EC:2.1.1.77UniRule annotation)
Gene namesi
Name:PCMT1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000120265.16.
HGNCiHGNC:8728. PCMT1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120265.

PTM / Processingi

Proteomic databases

EPDiH7BY58.
MaxQBiH7BY58.
PaxDbiH7BY58.
PeptideAtlasiH7BY58.
PRIDEiH7BY58.

Expressioni

Gene expression databases

BgeeiENSG00000120265.
ExpressionAtlasiH7BY58. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH7BY58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1661. Eukaryota.
COG2518. LUCA.
GeneTreeiENSGT00510000046974.
OMAiPYTVAFQ.
OrthoDBiEOG091G0OTG.
PhylomeDBiH7BY58.

Family and domain databases

InterProiView protein in InterPro
IPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiView protein in PROSITE
PS01279. PCMT. 1 hit.

Sequencei

Sequence statusi: Complete.

H7BY58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGARSGGSG GDGSNSGSYS GDASGAVTVW EVVSLLGKLL GTVVALKVVL
60 70 80 90 100
YLLRVCLAMA WKSGGASHSE LIHNLRKNGI IKTDKVFEVM LATDRSHYAK
110 120 130 140 150
CNPYMDSPQS IGFQATISAP HMHAYALELL FDQLHEGAKA LDVGSGSGIL
160 170 180 190 200
TACFARMVGC TGKVIGIDHI KELVDDSVNN VRKDDPTLLS SGRVQLVVGD
210 220 230 240 250
GRMGYAEEAP YDAIHVGAAA PVVPQALIDQ LKPGGRLILP VGPAGGNQML
260 270 280
EQYDKLQDGS IKMKPLMGVI YVPLTDKEKQ WSRDEL
Length:286
Mass (Da):30,358
Last modified:April 18, 2012 - v1
Checksum:iBBA9E5E89FC5729A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355312 Genomic DNA. No translation available.
RefSeqiNP_001238978.1. NM_001252049.1.
UniGeneiHs.279257.

Genome annotation databases

EnsembliENST00000367384; ENSP00000356354; ENSG00000120265.
GeneIDi5110.
UCSCiuc003qne.4. human.

Similar proteinsi

Entry informationi

Entry nameiH7BY58_HUMAN
AccessioniPrimary (citable) accession number: H7BY58
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 27, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported