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H7BY35 (H7BY35_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length4973 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000353174

Ontologies

Sequences

Sequence LengthMass (Da)Tools
H7BY35 [UniParc].

Last modified April 18, 2012. Version 1.
Checksum: 41C9306078BAFDF6

FASTA4,973565,484
        10         20         30         40         50         60 
LGPRSSSNKL SNKKMMKWFC SAPQPSTKNN RSYAWQQKDL ATDFVSWSPL PIPRMCPQTS 

        70         80         90        100        110        120 
PSAPLCWSSP SLSGRCRRCW LTPWRNQKGQ LDIIKWSFGL KTAQGGGHRT LLYGHAILLR 

       130        140        150        160        170        180 
HSYSGMYLCC LSTSRSSTDK LAFDVGLQED TTGEACWWTI HPASKQRSEG EKVRVGDDLI 

       190        200        210        220        230        240 
LVSVSSERYL HLSYGNGSLH VDAAFQQTLW SVAPISSGSE AAQGYLIGGD VLRLLHGHMD 

       250        260        270        280        290        300 
ECLTVPSGEH GEEQRRTVHY EGGAVSVHAR SLWRLETLRV AWSGSHIRWG QPFRLRHVTT 

       310        320        330        340        350        360 
GKYLSLMEDK NLLLMDKEKA DVKSTAFTFR SSKEKLDVGV RKEVDGMGTS EIKYGDSVCY 

       370        380        390        400        410        420 
IQHVDTGLWL TYQSVDVKSV RMGSIQRKAI MHHEGHMDDG ISLSRSQHEE SRTARVIRST 

       430        440        450        460        470        480 
VFLFNRFIRG LDALSKKAKA STVDLPIESV SLSLQDLIGY FHPPDEHLEH EDKQNRLRAL 

       490        500        510        520        530        540 
KNRQNLFQEE GMINLVLECI DRLHVYSSAA HFADVAGREA GESWKSILNS LYELLAALIR 

       550        560        570        580        590        600 
GNRKNCAQFS GSLDWLISRL ERLEASSGIL EVLHCVLVES PEALNIIKEG HIKSIISLLD 

       610        620        630        640        650        660 
KHGRNHKVLD VLCSLCVCHG VAVRSNQHLI CDNLLPGRDL LLQTRLVNHV SSMRPNIFLG 

       670        680        690        700        710        720 
VSEGSAQYKK WYYELMVDHT EPFVTAEATH LRVGWASTEG YSPYPGGGEE WGGNGVGDDL 

       730        740        750        760        770        780 
FSYGFDGLHL WSGCIARTVS SPNQHLLRTD DVISCCLDLS APSISFRING QPVQGMFENF 

       790        800        810        820        830        840 
NIDGLFFPVV SFSAGIKVRF LLGGRHGEFK FLPPPGYAPC YEAVLPKEKL KVEHSREYKQ 

       850        860        870        880        890        900 
ERTYTRDLLG PTVSLTQAAF TPIPVDTSQI VLPPHLERIR EKLAENIHEL WVMNKIELGW 

       910        920        930        940        950        960 
QYGPVRDDNK RQHPCLVEFS KLPEQERNYN LQMSLETLKT LLALGCHVGI SDEHAEDKVK 

       970        980        990       1000       1010       1020 
KMKLPKNYQL TSGYKPAPMD LSFIKLTPSQ EAMVDKLAEN AHNVWARDRI RQGWTYGIQQ 

      1030       1040       1050       1060       1070       1080 
DVKNRRNPRL VPYTLLDDRT KKSNKDSLRE AVRTLLGYGY NLEAPDQDHA ARAEVCSGTG 

      1090       1100       1110       1120       1130       1140 
ERFRIFRAEK TYAVKAGRWY FEFETVTAGD MRVGWSRPGC QPDQELGSDE RAFAFDGFKA 

      1150       1160       1170       1180       1190       1200 
QRWHQGNEHY GRSWQAGDVV GCMVDMNEHT MMFTLNGEIL LDDSGSELAF KDFDVGDGFI 

      1210       1220       1230       1240       1250       1260 
PVCSLGVAQV GRMNFGKDVS TLKYFTICGL QEGYEPFAVN TNRDITMWLS KRLPQFLQVP 

      1270       1280       1290       1300       1310       1320 
SNHEHIEVTR IDGTIDSSPC LKVTQKSFGS QNSNTDIMFY RLSMPIECAE VFSKTVAGGL 

      1330       1340       1350       1360       1370       1380 
PGAGLFGPKN DLEDYDADSD FEVLMKTAHG HLVPDRVDKD KEATKPEFNN HKDYAQEKPS 

      1390       1400       1410       1420       1430       1440 
RLKQRFLLRR TKPDYSTSHS ARLTEDVLAD DRDDYDFLMQ TSTYYYSVRI FPGQEPANVW 

      1450       1460       1470       1480       1490       1500 
VGWITSDFHQ YDTGFDLDRV RTVTVTLGDE KGKVHESIKR SNCYMVCAGE SMSPGQGRNN 

      1510       1520       1530       1540       1550       1560 
NGLEIGCVVD AASGLLTFIA NGKELSTYYQ VEPSTKLFPA VFAQATSPNV FQFELGRIKN 

      1570       1580       1590       1600       1610       1620 
VMPLSAGLFK SEHKNPVPQC PPRLHVQFLS HVLWSRMPNQ FLKVDVSRIS ERQGWLVQCL 

      1630       1640       1650       1660       1670       1680 
DPLQFMSLHI PEENRSVDIL ELTEQEELLK FHYHTLRLYS AVCALGNHRV AHALCSHVDE 

      1690       1700       1710       1720       1730       1740 
PQLLYAIENK YMPGLLRAGY YDLLIDIHLS SYATARLMMN NEYIVPMTEE TKSITLFPDE 

      1750       1760       1770       1780       1790       1800 
NKKHGLPGIG LSTSLRPRMQ FSSPSFVSIS NECYQYSPEF PLDILKSKTI QMLTEAVKEG 

      1810       1820       1830       1840       1850       1860 
SLHARDPVGG TTEFLFVPLI KLFYTLLIMG IFHNEDLKHI LQLIEPSVFK EAATPEEESD 

      1870       1880       1890       1900       1910       1920 
TLEKELSVDD AKLQGAGEEE AKGGKRPKEG LLQMKLPEPV KLQMCLLLQY LCDCQVRHRI 

      1930       1940       1950       1960       1970       1980 
EAIVAFSDDF VAKLQDNQRF RYNEVMQALN MSAALTARKT KEFRSPPQEQ INMLLNFKDD 

      1990       2000       2010       2020       2030       2040 
KSECPCPEEI RDQLLDFHED LMTHCGIELD EDGSLDGNSD LTIRGRLLSL VEKVTYLKKK 

      2050       2060       2070       2080       2090       2100 
QAEKPVESDS KKSSTLQQLI SETMVRWAQE SVIEDPELVR AMFVLLHRQY DGIGGLVRAL 

      2110       2120       2130       2140       2150       2160 
PKTYTINGVS VEDTINLLAS LGQIRSLLSV RMGKEEEKLM IRGLGDIMNN KVFYQHPNLM 

      2170       2180       2190       2200       2210       2220 
RALGMHETVM EVMVNVLGGG ESKEITFPKM VANCCRFLCY FCRISRQNQK AMFDHLSYLL 

      2230       2240       2250       2260       2270       2280 
ENSSVGLASP AMRGSTPLDV AAASVMDNNE LALALREPDL EKVVRYLAGC GLQSCQMLVS 

      2290       2300       2310       2320       2330       2340 
KGYPDIGWNP VEGERYLDFL RFAVFCNGES VEENANVVVR LLIRRPECFG PALRGEGGNG 

      2350       2360       2370       2380       2390       2400 
LLAAMEEAIK IAEDPSRDGP SPNSGSSKTL DTEEEEDDTI HMGNAIMTFY SALIDLLGRC 

      2410       2420       2430       2440       2450       2460 
APEMHLIHAG KGEAIRIRSI LRSLIPLGDL VGVISIAFQM PTIAKDGNVV EPDMSAGFCP 

      2470       2480       2490       2500       2510       2520 
DHKAAMVLFL DRVYGIEVQD FLLHLLEVGF LPDLRAAASL DTAALSATDM ALALNRYLCT 

      2530       2540       2550       2560       2570       2580 
AVLPLLTRCA PLFAGTEHHA SLIDSLLHTV YRLSKGCSLT KAQRDSIEVC LLSICGQLRP 

      2590       2600       2610       2620       2630       2640 
SMMQHLLRRL VFDVPLLNEH AKMPLKLLTN HYERCWKYYC LPGGWGNFGA ASEEELHLSR 

      2650       2660       2670       2680       2690       2700 
KLFWGIFDAL SQKKYEQELF KLALPCLSAV AGALPPDYME SNYVSMMEKQ SSMDSEGNFN 

      2710       2720       2730       2740       2750       2760 
PQPVDTSNIT IPEKLEYFIN KYAEHSHDKW SMDKLANGWI YGEIYSDSSK VQPLMKPYKL 

      2770       2780       2790       2800       2810       2820 
LSEKEKEIYR WPIKESLKTM LAWGWRIERT REGDSMALYN RTRRISQTSQ VSVDAAHGYS 

      2830       2840       2850       2860       2870       2880 
PRAIDMSNVT LSRDLHAMAE MMAENYHNIW AKKKKMELES KGGGNHPLLV PYDTLTAKEK 

      2890       2900       2910       2920       2930       2940 
AKDREKAQDI LKFLQINGYA VSRGFKDLEL DTPSIEKRFA YSFLQQLIRY VDEAHQYILE 

      2950       2960       2970       2980       2990       3000 
FDGGSRGKGE HFPYEQEIKF FAKVVLPLID QYFKNHRLYF LSAASRPLCS GGHASNKEKE 

      3010       3020       3030       3040       3050       3060 
MVTSLFCKLG VLVRHRISLF GNDATSIVNC LHILGQTLDA RTVMKTGLES VKSALRAFLD 

      3070       3080       3090       3100       3110       3120 
NAAEDLEKTM ENLKQGQFTH TRNQPKGVTQ IINYTTVALL PMLSSLFEHI GQHQFGEDLI 

      3130       3140       3150       3160       3170       3180 
LEDVQVSCYR ILTSLYALGT SKSIYVERQR SALGECLAAF AGAFPVAFLE THLDKHNIYS 

      3190       3200       3210       3220       3230       3240 
IYNTKSSRER AALSLPTNVE DVCPNIPSLE KLMEEIVELA ESGIRYTQMP HVMEVILPML 

      3250       3260       3270       3280       3290       3300 
CSYMSRWWEH GPENNPERAE MCCTALNSEH MNTLLGNILK IIYNNLGIDE GAWMKRLAVF 

      3310       3320       3330       3340       3350       3360 
SQPIINKVKP QLLKTHFLPL MEKLKKKAAT VVSEEDHLKA EARGDMSEAE LLILDEFTTL 

      3370       3380       3390       3400       3410       3420 
ARDLYAFYPL LIRFVDYNRA KWLKEPNPEA EELFRMVAEV FIYWSKSHNF KREEQNFVVQ 

      3430       3440       3450       3460       3470       3480 
NEINNMSFLI TDTKSKMSKA AVSDQERKKM KRKGDRYSMQ TSLIVAALKR LLPIGLNICA 

      3490       3500       3510       3520       3530       3540 
PGDQELIALA KNRFSLKDTE DEVRDIIRSN IHLQGKLEDP AIRWQMALYK DLPNRTDDTS 

      3550       3560       3570       3580       3590       3600 
DPEKTVERVL DIANVLFHLE QKSKRVGRRH YCLVEHPQRS KKAVWHKLLS KQRKRAVVAC 

      3610       3620       3630       3640       3650       3660 
FRMAPLYNLP RHRAVNLFLQ GYEKSWIETE EHYFEDKLIE DLAKPGAEPP EEDEGTKRVD 

      3670       3680       3690       3700       3710       3720 
PLHQLILLFS RTALTEKCKL EEDFLYMAYA DIMAKSCHDE EDDDGEEEVK SFEVTGSQRS 

      3730       3740       3750       3760       3770       3780 
KEKEMEKQKL LYQQARLHDR GAAEMVLQTI SASKGETGPM VAATLKLGIA ILNGGNSTVQ 

      3790       3800       3810       3820       3830       3840 
QKMLDYLKEK KDVGFFQSLA GLMQSCSVLD LNAFERQNKA EGLGMVTEEG SGEKVLQDDE 

      3850       3860       3870       3880       3890       3900 
FTCDLFRFLQ LLCEGHNSDF QNYLRTQTGN NTTVNIIIST VDYLLRVQES ISDFYWYYSG 

      3910       3920       3930       3940       3950       3960 
KDVIDEQGQR NFSKAIQVAK QVFNTLTEYI QGPCTGNQQS LAHSRLWDAV VGFLHVFAHM 

      3970       3980       3990       4000       4010       4020 
QMKLSQDSSQ IELLKELMDL QKDMVVMLLS MLEGNVVNGT IGKQMVDMLV ESSNNVEMIL 

      4030       4040       4050       4060       4070       4080 
KFFDMFLKLK DLTSSDTFKE YDPDGKGVIS KRDFHKAMES HKHYTQSETE FLLSCAETDE 

      4090       4100       4110       4120       4130       4140 
NETLDYEEFV KRFHEPAKDI GFNVAVLLTN LSEHMPNDTR LQTFLELAES VLNYFQPFLG 

      4150       4160       4170       4180       4190       4200 
RIEIMGSAKR IERVYFEISE SSRTQWEKPQ VKESKRQFIF DVVNEGGEKE KMELFVNFCE 

      4210       4220       4230       4240       4250       4260 
DTIFEMQLAA QISESDLNER SANKEESEKE RPEEQGPRMA FFSILTVRSA LFALRYNILT 

      4270       4280       4290       4300       4310       4320 
LMRMLSLKSL KKQMKKVKKM TVKDMVTAFF SSYWSIFMTL LHFVASVFRG FFRIICSLLL 

      4330       4340       4350       4360       4370       4380 
GGSLVEGAKK IKVAELLANM PDPTQDEVRG DGEEGERKPL EAALPSEDLT DLKELTEESD 

      4390       4400       4410       4420       4430       4440 
LLSDIFGLDL KREGGQYKLI PHNPNAGLSD LMSNPVPMPE VQEKFQEQKA KEEEKEEKEE 

      4450       4460       4470       4480       4490       4500 
TKSEPEKAEG EDGEKEEKAK EDKGKQKLRQ LHTHRYGEPE VPESAFWKKI IAYQQKLLNY 

      4510       4520       4530       4540       4550       4560 
FARNFYNMRM LALFVAFAIN FILLFYKVST SSVVEGKELP TRSSSENAKV TSLDSSSHRI 

      4570       4580       4590       4600       4610       4620 
IAVHYVLEES SGYMEPTLRI LAILHTVISF FCIIGYYCLK VPLVIFKREK EVARKLEFDG 

      4630       4640       4650       4660       4670       4680 
LYITEQPSED DIKGQWDRLV INTQSFPNNY WDKFVKRKVM DKYGEFYGRD RISELLGMDK 

      4690       4700       4710       4720       4730       4740 
AALDFSDARE KKKPKKDSSL SAVLNSIDVK YQMWKLGVVF TDNSFLYLAW YMTMSVLGHY 

      4750       4760       4770       4780       4790       4800 
NNFFFAAHLL DIAMGFKTLR TILSSVTHNG KQLVLTVGLL AVVVYLYTVV AFNFFRKFYN 

      4810       4820       4830       4840       4850       4860 
KSEDGDTPDM KCDDMLTCYM FHMYVGVRAG GGIGDEIEDP AGDEYEIYRI IFDITFFFFV 

      4870       4880       4890       4900       4910       4920 
IVILLAIIQG LIIDAFGELR DQQEQVKEDM ETKCFICGIG NDYFDTVPHG FETHTLQEHN 

      4930       4940       4950       4960       4970 
LANYLFFLMY LINKDETEHT GQESYVWKMY QERCWEFFPA GDCFRKQYED QLN 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., Porter K.M., Prigmore E.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL356773 Genomic DNA. No translation available.
AL359924 Genomic DNA. No translation available.
AL365332 Genomic DNA. No translation available.
AL391809 Genomic DNA. No translation available.
AL442065 Genomic DNA. No translation available.
AL445473 Genomic DNA. No translation available.
AL513130 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalH7BY35.
SMRH7BY35. Positions 65-543, 2699-2903, 3579-3605.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360064; ENSP00000353174; ENSG00000198626.

Organism-specific databases

HGNCHGNC:10484. RYR2.
GenAtlasSearch...

Phylogenomic databases

OMASKVQPLM.

Gene expression databases

ArrayExpressH7BY35.
BgeeH7BY35.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]
PANTHERPTHR13715. PTHR13715. 1 hit.
PfamPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSPR00795. RYANODINER.
SMARTSM00054. EFh. 2 hits.
SM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMSSF100909. SSF100909. 2 hits.
SSF49899. SSF49899. 2 hits.
SSF82109. SSF82109. 2 hits.
PROSITEPS50188. B302_SPRY. 3 hits.
PS50222. EF_HAND_2. 1 hit.
PS50919. MIR. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRYR2. human.
NextBio35528156.

Entry information

Entry nameH7BY35_HUMAN
AccessionPrimary (citable) accession number: H7BY35
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: March 19, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.