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H7BY35

- H7BY35_HUMAN

UniProt

H7BY35 - H7BY35_HUMAN

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Protein
Submitted name: Ryanodine receptor 2
Gene
RYR2
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. ryanodine-sensitive calcium-release channel activity Source: InterPro

GO - Biological processi

  1. cellular calcium ion homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Ryanodine receptor 2Imported
Gene namesi
Name:RYR2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10484. RYR2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ArrayExpressiH7BY35.
BgeeiH7BY35.

Structurei

3D structure databases

ProteinModelPortaliH7BY35.
SMRiH7BY35. Positions 65-543, 2699-2903, 3579-3605.

Family & Domainsi

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

OMAiSKVQPLM.
PhylomeDBiH7BY35.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00054. EFh. 2 hits.
SM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF49899. SSF49899. 2 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS50222. EF_HAND_2. 1 hit.
PS50919. MIR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H7BY35-1 [UniParc]FASTAAdd to Basket

« Hide

LGPRSSSNKL SNKKMMKWFC SAPQPSTKNN RSYAWQQKDL ATDFVSWSPL     50
PIPRMCPQTS PSAPLCWSSP SLSGRCRRCW LTPWRNQKGQ LDIIKWSFGL 100
KTAQGGGHRT LLYGHAILLR HSYSGMYLCC LSTSRSSTDK LAFDVGLQED 150
TTGEACWWTI HPASKQRSEG EKVRVGDDLI LVSVSSERYL HLSYGNGSLH 200
VDAAFQQTLW SVAPISSGSE AAQGYLIGGD VLRLLHGHMD ECLTVPSGEH 250
GEEQRRTVHY EGGAVSVHAR SLWRLETLRV AWSGSHIRWG QPFRLRHVTT 300
GKYLSLMEDK NLLLMDKEKA DVKSTAFTFR SSKEKLDVGV RKEVDGMGTS 350
EIKYGDSVCY IQHVDTGLWL TYQSVDVKSV RMGSIQRKAI MHHEGHMDDG 400
ISLSRSQHEE SRTARVIRST VFLFNRFIRG LDALSKKAKA STVDLPIESV 450
SLSLQDLIGY FHPPDEHLEH EDKQNRLRAL KNRQNLFQEE GMINLVLECI 500
DRLHVYSSAA HFADVAGREA GESWKSILNS LYELLAALIR GNRKNCAQFS 550
GSLDWLISRL ERLEASSGIL EVLHCVLVES PEALNIIKEG HIKSIISLLD 600
KHGRNHKVLD VLCSLCVCHG VAVRSNQHLI CDNLLPGRDL LLQTRLVNHV 650
SSMRPNIFLG VSEGSAQYKK WYYELMVDHT EPFVTAEATH LRVGWASTEG 700
YSPYPGGGEE WGGNGVGDDL FSYGFDGLHL WSGCIARTVS SPNQHLLRTD 750
DVISCCLDLS APSISFRING QPVQGMFENF NIDGLFFPVV SFSAGIKVRF 800
LLGGRHGEFK FLPPPGYAPC YEAVLPKEKL KVEHSREYKQ ERTYTRDLLG 850
PTVSLTQAAF TPIPVDTSQI VLPPHLERIR EKLAENIHEL WVMNKIELGW 900
QYGPVRDDNK RQHPCLVEFS KLPEQERNYN LQMSLETLKT LLALGCHVGI 950
SDEHAEDKVK KMKLPKNYQL TSGYKPAPMD LSFIKLTPSQ EAMVDKLAEN 1000
AHNVWARDRI RQGWTYGIQQ DVKNRRNPRL VPYTLLDDRT KKSNKDSLRE 1050
AVRTLLGYGY NLEAPDQDHA ARAEVCSGTG ERFRIFRAEK TYAVKAGRWY 1100
FEFETVTAGD MRVGWSRPGC QPDQELGSDE RAFAFDGFKA QRWHQGNEHY 1150
GRSWQAGDVV GCMVDMNEHT MMFTLNGEIL LDDSGSELAF KDFDVGDGFI 1200
PVCSLGVAQV GRMNFGKDVS TLKYFTICGL QEGYEPFAVN TNRDITMWLS 1250
KRLPQFLQVP SNHEHIEVTR IDGTIDSSPC LKVTQKSFGS QNSNTDIMFY 1300
RLSMPIECAE VFSKTVAGGL PGAGLFGPKN DLEDYDADSD FEVLMKTAHG 1350
HLVPDRVDKD KEATKPEFNN HKDYAQEKPS RLKQRFLLRR TKPDYSTSHS 1400
ARLTEDVLAD DRDDYDFLMQ TSTYYYSVRI FPGQEPANVW VGWITSDFHQ 1450
YDTGFDLDRV RTVTVTLGDE KGKVHESIKR SNCYMVCAGE SMSPGQGRNN 1500
NGLEIGCVVD AASGLLTFIA NGKELSTYYQ VEPSTKLFPA VFAQATSPNV 1550
FQFELGRIKN VMPLSAGLFK SEHKNPVPQC PPRLHVQFLS HVLWSRMPNQ 1600
FLKVDVSRIS ERQGWLVQCL DPLQFMSLHI PEENRSVDIL ELTEQEELLK 1650
FHYHTLRLYS AVCALGNHRV AHALCSHVDE PQLLYAIENK YMPGLLRAGY 1700
YDLLIDIHLS SYATARLMMN NEYIVPMTEE TKSITLFPDE NKKHGLPGIG 1750
LSTSLRPRMQ FSSPSFVSIS NECYQYSPEF PLDILKSKTI QMLTEAVKEG 1800
SLHARDPVGG TTEFLFVPLI KLFYTLLIMG IFHNEDLKHI LQLIEPSVFK 1850
EAATPEEESD TLEKELSVDD AKLQGAGEEE AKGGKRPKEG LLQMKLPEPV 1900
KLQMCLLLQY LCDCQVRHRI EAIVAFSDDF VAKLQDNQRF RYNEVMQALN 1950
MSAALTARKT KEFRSPPQEQ INMLLNFKDD KSECPCPEEI RDQLLDFHED 2000
LMTHCGIELD EDGSLDGNSD LTIRGRLLSL VEKVTYLKKK QAEKPVESDS 2050
KKSSTLQQLI SETMVRWAQE SVIEDPELVR AMFVLLHRQY DGIGGLVRAL 2100
PKTYTINGVS VEDTINLLAS LGQIRSLLSV RMGKEEEKLM IRGLGDIMNN 2150
KVFYQHPNLM RALGMHETVM EVMVNVLGGG ESKEITFPKM VANCCRFLCY 2200
FCRISRQNQK AMFDHLSYLL ENSSVGLASP AMRGSTPLDV AAASVMDNNE 2250
LALALREPDL EKVVRYLAGC GLQSCQMLVS KGYPDIGWNP VEGERYLDFL 2300
RFAVFCNGES VEENANVVVR LLIRRPECFG PALRGEGGNG LLAAMEEAIK 2350
IAEDPSRDGP SPNSGSSKTL DTEEEEDDTI HMGNAIMTFY SALIDLLGRC 2400
APEMHLIHAG KGEAIRIRSI LRSLIPLGDL VGVISIAFQM PTIAKDGNVV 2450
EPDMSAGFCP DHKAAMVLFL DRVYGIEVQD FLLHLLEVGF LPDLRAAASL 2500
DTAALSATDM ALALNRYLCT AVLPLLTRCA PLFAGTEHHA SLIDSLLHTV 2550
YRLSKGCSLT KAQRDSIEVC LLSICGQLRP SMMQHLLRRL VFDVPLLNEH 2600
AKMPLKLLTN HYERCWKYYC LPGGWGNFGA ASEEELHLSR KLFWGIFDAL 2650
SQKKYEQELF KLALPCLSAV AGALPPDYME SNYVSMMEKQ SSMDSEGNFN 2700
PQPVDTSNIT IPEKLEYFIN KYAEHSHDKW SMDKLANGWI YGEIYSDSSK 2750
VQPLMKPYKL LSEKEKEIYR WPIKESLKTM LAWGWRIERT REGDSMALYN 2800
RTRRISQTSQ VSVDAAHGYS PRAIDMSNVT LSRDLHAMAE MMAENYHNIW 2850
AKKKKMELES KGGGNHPLLV PYDTLTAKEK AKDREKAQDI LKFLQINGYA 2900
VSRGFKDLEL DTPSIEKRFA YSFLQQLIRY VDEAHQYILE FDGGSRGKGE 2950
HFPYEQEIKF FAKVVLPLID QYFKNHRLYF LSAASRPLCS GGHASNKEKE 3000
MVTSLFCKLG VLVRHRISLF GNDATSIVNC LHILGQTLDA RTVMKTGLES 3050
VKSALRAFLD NAAEDLEKTM ENLKQGQFTH TRNQPKGVTQ IINYTTVALL 3100
PMLSSLFEHI GQHQFGEDLI LEDVQVSCYR ILTSLYALGT SKSIYVERQR 3150
SALGECLAAF AGAFPVAFLE THLDKHNIYS IYNTKSSRER AALSLPTNVE 3200
DVCPNIPSLE KLMEEIVELA ESGIRYTQMP HVMEVILPML CSYMSRWWEH 3250
GPENNPERAE MCCTALNSEH MNTLLGNILK IIYNNLGIDE GAWMKRLAVF 3300
SQPIINKVKP QLLKTHFLPL MEKLKKKAAT VVSEEDHLKA EARGDMSEAE 3350
LLILDEFTTL ARDLYAFYPL LIRFVDYNRA KWLKEPNPEA EELFRMVAEV 3400
FIYWSKSHNF KREEQNFVVQ NEINNMSFLI TDTKSKMSKA AVSDQERKKM 3450
KRKGDRYSMQ TSLIVAALKR LLPIGLNICA PGDQELIALA KNRFSLKDTE 3500
DEVRDIIRSN IHLQGKLEDP AIRWQMALYK DLPNRTDDTS DPEKTVERVL 3550
DIANVLFHLE QKSKRVGRRH YCLVEHPQRS KKAVWHKLLS KQRKRAVVAC 3600
FRMAPLYNLP RHRAVNLFLQ GYEKSWIETE EHYFEDKLIE DLAKPGAEPP 3650
EEDEGTKRVD PLHQLILLFS RTALTEKCKL EEDFLYMAYA DIMAKSCHDE 3700
EDDDGEEEVK SFEVTGSQRS KEKEMEKQKL LYQQARLHDR GAAEMVLQTI 3750
SASKGETGPM VAATLKLGIA ILNGGNSTVQ QKMLDYLKEK KDVGFFQSLA 3800
GLMQSCSVLD LNAFERQNKA EGLGMVTEEG SGEKVLQDDE FTCDLFRFLQ 3850
LLCEGHNSDF QNYLRTQTGN NTTVNIIIST VDYLLRVQES ISDFYWYYSG 3900
KDVIDEQGQR NFSKAIQVAK QVFNTLTEYI QGPCTGNQQS LAHSRLWDAV 3950
VGFLHVFAHM QMKLSQDSSQ IELLKELMDL QKDMVVMLLS MLEGNVVNGT 4000
IGKQMVDMLV ESSNNVEMIL KFFDMFLKLK DLTSSDTFKE YDPDGKGVIS 4050
KRDFHKAMES HKHYTQSETE FLLSCAETDE NETLDYEEFV KRFHEPAKDI 4100
GFNVAVLLTN LSEHMPNDTR LQTFLELAES VLNYFQPFLG RIEIMGSAKR 4150
IERVYFEISE SSRTQWEKPQ VKESKRQFIF DVVNEGGEKE KMELFVNFCE 4200
DTIFEMQLAA QISESDLNER SANKEESEKE RPEEQGPRMA FFSILTVRSA 4250
LFALRYNILT LMRMLSLKSL KKQMKKVKKM TVKDMVTAFF SSYWSIFMTL 4300
LHFVASVFRG FFRIICSLLL GGSLVEGAKK IKVAELLANM PDPTQDEVRG 4350
DGEEGERKPL EAALPSEDLT DLKELTEESD LLSDIFGLDL KREGGQYKLI 4400
PHNPNAGLSD LMSNPVPMPE VQEKFQEQKA KEEEKEEKEE TKSEPEKAEG 4450
EDGEKEEKAK EDKGKQKLRQ LHTHRYGEPE VPESAFWKKI IAYQQKLLNY 4500
FARNFYNMRM LALFVAFAIN FILLFYKVST SSVVEGKELP TRSSSENAKV 4550
TSLDSSSHRI IAVHYVLEES SGYMEPTLRI LAILHTVISF FCIIGYYCLK 4600
VPLVIFKREK EVARKLEFDG LYITEQPSED DIKGQWDRLV INTQSFPNNY 4650
WDKFVKRKVM DKYGEFYGRD RISELLGMDK AALDFSDARE KKKPKKDSSL 4700
SAVLNSIDVK YQMWKLGVVF TDNSFLYLAW YMTMSVLGHY NNFFFAAHLL 4750
DIAMGFKTLR TILSSVTHNG KQLVLTVGLL AVVVYLYTVV AFNFFRKFYN 4800
KSEDGDTPDM KCDDMLTCYM FHMYVGVRAG GGIGDEIEDP AGDEYEIYRI 4850
IFDITFFFFV IVILLAIIQG LIIDAFGELR DQQEQVKEDM ETKCFICGIG 4900
NDYFDTVPHG FETHTLQEHN LANYLFFLMY LINKDETEHT GQESYVWKMY 4950
QERCWEFFPA GDCFRKQYED QLN 4973
Length:4,973
Mass (Da):565,484
Last modified:April 18, 2012 - v1
Checksum:i41C9306078BAFDF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL356773 Genomic DNA. No translation available.
AL359924 Genomic DNA. No translation available.
AL365332 Genomic DNA. No translation available.
AL391809 Genomic DNA. No translation available.
AL442065 Genomic DNA. No translation available.
AL445473 Genomic DNA. No translation available.
AL513130 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000360064; ENSP00000353174; ENSG00000198626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL356773 Genomic DNA. No translation available.
AL359924 Genomic DNA. No translation available.
AL365332 Genomic DNA. No translation available.
AL391809 Genomic DNA. No translation available.
AL442065 Genomic DNA. No translation available.
AL445473 Genomic DNA. No translation available.
AL513130 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali H7BY35.
SMRi H7BY35. Positions 65-543, 2699-2903, 3579-3605.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360064 ; ENSP00000353174 ; ENSG00000198626 .

Organism-specific databases

HGNCi HGNC:10484. RYR2.
GenAtlasi Search...

Phylogenomic databases

OMAi SKVQPLM.
PhylomeDBi H7BY35.

Miscellaneous databases

ChiTaRSi RYR2. human.
NextBioi 35528156.

Gene expression databases

ArrayExpressi H7BY35.
Bgeei H7BY35.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view ]
PANTHERi PTHR13715. PTHR13715. 1 hit.
Pfami PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view ]
PRINTSi PR00795. RYANODINER.
SMARTi SM00054. EFh. 2 hits.
SM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view ]
SUPFAMi SSF100909. SSF100909. 2 hits.
SSF49899. SSF49899. 2 hits.
SSF82109. SSF82109. 2 hits.
PROSITEi PS50188. B302_SPRY. 3 hits.
PS50222. EF_HAND_2. 1 hit.
PS50919. MIR. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., Porter K.M., Prigmore E.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH7BY35_HUMAN
AccessioniPrimary (citable) accession number: H7BY35
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: July 9, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi