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H7BY35

- H7BY35_HUMAN

UniProt

H7BY35 - H7BY35_HUMAN

Protein
Submitted name:

Ryanodine receptor 2

Gene

RYR2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. ryanodine-sensitive calcium-release channel activity Source: InterPro

    GO - Biological processi

    1. cellular calcium ion homeostasis Source: InterPro

    Keywords - Molecular functioni

    Ion channelUniRule annotation

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Ryanodine receptor 2Imported
    Gene namesi
    Name:RYR2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10484. RYR2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiH7BY35.
    BgeeiH7BY35.

    Structurei

    3D structure databases

    ProteinModelPortaliH7BY35.
    SMRiH7BY35. Positions 65-543, 2699-2903, 3579-3605.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    OMAiSKVQPLM.
    PhylomeDBiH7BY35.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.25.10.30. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR008985. ConA-like_lec_gl_sf.
    IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR014821. Ins145_P3_rcpt.
    IPR005821. Ion_trans_dom.
    IPR016093. MIR_motif.
    IPR013662. RIH_assoc-dom.
    IPR000699. RIH_dom.
    IPR013333. Ryan_recept.
    IPR003032. Ryanodine_rcpt.
    IPR015925. Ryanodine_recept-rel.
    IPR009460. Ryanrecept_TM4-6.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view]
    PANTHERiPTHR13715. PTHR13715. 1 hit.
    PfamiPF08709. Ins145_P3_rec. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF02815. MIR. 1 hit.
    PF08454. RIH_assoc. 1 hit.
    PF06459. RR_TM4-6. 1 hit.
    PF01365. RYDR_ITPR. 2 hits.
    PF02026. RyR. 4 hits.
    PF00622. SPRY. 3 hits.
    [Graphical view]
    PRINTSiPR00795. RYANODINER.
    SMARTiSM00054. EFh. 2 hits.
    SM00472. MIR. 4 hits.
    SM00449. SPRY. 3 hits.
    [Graphical view]
    SUPFAMiSSF100909. SSF100909. 2 hits.
    SSF49899. SSF49899. 2 hits.
    SSF82109. SSF82109. 2 hits.
    PROSITEiPS50188. B302_SPRY. 3 hits.
    PS50222. EF_HAND_2. 1 hit.
    PS50919. MIR. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H7BY35-1 [UniParc]FASTAAdd to Basket

    « Hide

    LGPRSSSNKL SNKKMMKWFC SAPQPSTKNN RSYAWQQKDL ATDFVSWSPL     50
    PIPRMCPQTS PSAPLCWSSP SLSGRCRRCW LTPWRNQKGQ LDIIKWSFGL 100
    KTAQGGGHRT LLYGHAILLR HSYSGMYLCC LSTSRSSTDK LAFDVGLQED 150
    TTGEACWWTI HPASKQRSEG EKVRVGDDLI LVSVSSERYL HLSYGNGSLH 200
    VDAAFQQTLW SVAPISSGSE AAQGYLIGGD VLRLLHGHMD ECLTVPSGEH 250
    GEEQRRTVHY EGGAVSVHAR SLWRLETLRV AWSGSHIRWG QPFRLRHVTT 300
    GKYLSLMEDK NLLLMDKEKA DVKSTAFTFR SSKEKLDVGV RKEVDGMGTS 350
    EIKYGDSVCY IQHVDTGLWL TYQSVDVKSV RMGSIQRKAI MHHEGHMDDG 400
    ISLSRSQHEE SRTARVIRST VFLFNRFIRG LDALSKKAKA STVDLPIESV 450
    SLSLQDLIGY FHPPDEHLEH EDKQNRLRAL KNRQNLFQEE GMINLVLECI 500
    DRLHVYSSAA HFADVAGREA GESWKSILNS LYELLAALIR GNRKNCAQFS 550
    GSLDWLISRL ERLEASSGIL EVLHCVLVES PEALNIIKEG HIKSIISLLD 600
    KHGRNHKVLD VLCSLCVCHG VAVRSNQHLI CDNLLPGRDL LLQTRLVNHV 650
    SSMRPNIFLG VSEGSAQYKK WYYELMVDHT EPFVTAEATH LRVGWASTEG 700
    YSPYPGGGEE WGGNGVGDDL FSYGFDGLHL WSGCIARTVS SPNQHLLRTD 750
    DVISCCLDLS APSISFRING QPVQGMFENF NIDGLFFPVV SFSAGIKVRF 800
    LLGGRHGEFK FLPPPGYAPC YEAVLPKEKL KVEHSREYKQ ERTYTRDLLG 850
    PTVSLTQAAF TPIPVDTSQI VLPPHLERIR EKLAENIHEL WVMNKIELGW 900
    QYGPVRDDNK RQHPCLVEFS KLPEQERNYN LQMSLETLKT LLALGCHVGI 950
    SDEHAEDKVK KMKLPKNYQL TSGYKPAPMD LSFIKLTPSQ EAMVDKLAEN 1000
    AHNVWARDRI RQGWTYGIQQ DVKNRRNPRL VPYTLLDDRT KKSNKDSLRE 1050
    AVRTLLGYGY NLEAPDQDHA ARAEVCSGTG ERFRIFRAEK TYAVKAGRWY 1100
    FEFETVTAGD MRVGWSRPGC QPDQELGSDE RAFAFDGFKA QRWHQGNEHY 1150
    GRSWQAGDVV GCMVDMNEHT MMFTLNGEIL LDDSGSELAF KDFDVGDGFI 1200
    PVCSLGVAQV GRMNFGKDVS TLKYFTICGL QEGYEPFAVN TNRDITMWLS 1250
    KRLPQFLQVP SNHEHIEVTR IDGTIDSSPC LKVTQKSFGS QNSNTDIMFY 1300
    RLSMPIECAE VFSKTVAGGL PGAGLFGPKN DLEDYDADSD FEVLMKTAHG 1350
    HLVPDRVDKD KEATKPEFNN HKDYAQEKPS RLKQRFLLRR TKPDYSTSHS 1400
    ARLTEDVLAD DRDDYDFLMQ TSTYYYSVRI FPGQEPANVW VGWITSDFHQ 1450
    YDTGFDLDRV RTVTVTLGDE KGKVHESIKR SNCYMVCAGE SMSPGQGRNN 1500
    NGLEIGCVVD AASGLLTFIA NGKELSTYYQ VEPSTKLFPA VFAQATSPNV 1550
    FQFELGRIKN VMPLSAGLFK SEHKNPVPQC PPRLHVQFLS HVLWSRMPNQ 1600
    FLKVDVSRIS ERQGWLVQCL DPLQFMSLHI PEENRSVDIL ELTEQEELLK 1650
    FHYHTLRLYS AVCALGNHRV AHALCSHVDE PQLLYAIENK YMPGLLRAGY 1700
    YDLLIDIHLS SYATARLMMN NEYIVPMTEE TKSITLFPDE NKKHGLPGIG 1750
    LSTSLRPRMQ FSSPSFVSIS NECYQYSPEF PLDILKSKTI QMLTEAVKEG 1800
    SLHARDPVGG TTEFLFVPLI KLFYTLLIMG IFHNEDLKHI LQLIEPSVFK 1850
    EAATPEEESD TLEKELSVDD AKLQGAGEEE AKGGKRPKEG LLQMKLPEPV 1900
    KLQMCLLLQY LCDCQVRHRI EAIVAFSDDF VAKLQDNQRF RYNEVMQALN 1950
    MSAALTARKT KEFRSPPQEQ INMLLNFKDD KSECPCPEEI RDQLLDFHED 2000
    LMTHCGIELD EDGSLDGNSD LTIRGRLLSL VEKVTYLKKK QAEKPVESDS 2050
    KKSSTLQQLI SETMVRWAQE SVIEDPELVR AMFVLLHRQY DGIGGLVRAL 2100
    PKTYTINGVS VEDTINLLAS LGQIRSLLSV RMGKEEEKLM IRGLGDIMNN 2150
    KVFYQHPNLM RALGMHETVM EVMVNVLGGG ESKEITFPKM VANCCRFLCY 2200
    FCRISRQNQK AMFDHLSYLL ENSSVGLASP AMRGSTPLDV AAASVMDNNE 2250
    LALALREPDL EKVVRYLAGC GLQSCQMLVS KGYPDIGWNP VEGERYLDFL 2300
    RFAVFCNGES VEENANVVVR LLIRRPECFG PALRGEGGNG LLAAMEEAIK 2350
    IAEDPSRDGP SPNSGSSKTL DTEEEEDDTI HMGNAIMTFY SALIDLLGRC 2400
    APEMHLIHAG KGEAIRIRSI LRSLIPLGDL VGVISIAFQM PTIAKDGNVV 2450
    EPDMSAGFCP DHKAAMVLFL DRVYGIEVQD FLLHLLEVGF LPDLRAAASL 2500
    DTAALSATDM ALALNRYLCT AVLPLLTRCA PLFAGTEHHA SLIDSLLHTV 2550
    YRLSKGCSLT KAQRDSIEVC LLSICGQLRP SMMQHLLRRL VFDVPLLNEH 2600
    AKMPLKLLTN HYERCWKYYC LPGGWGNFGA ASEEELHLSR KLFWGIFDAL 2650
    SQKKYEQELF KLALPCLSAV AGALPPDYME SNYVSMMEKQ SSMDSEGNFN 2700
    PQPVDTSNIT IPEKLEYFIN KYAEHSHDKW SMDKLANGWI YGEIYSDSSK 2750
    VQPLMKPYKL LSEKEKEIYR WPIKESLKTM LAWGWRIERT REGDSMALYN 2800
    RTRRISQTSQ VSVDAAHGYS PRAIDMSNVT LSRDLHAMAE MMAENYHNIW 2850
    AKKKKMELES KGGGNHPLLV PYDTLTAKEK AKDREKAQDI LKFLQINGYA 2900
    VSRGFKDLEL DTPSIEKRFA YSFLQQLIRY VDEAHQYILE FDGGSRGKGE 2950
    HFPYEQEIKF FAKVVLPLID QYFKNHRLYF LSAASRPLCS GGHASNKEKE 3000
    MVTSLFCKLG VLVRHRISLF GNDATSIVNC LHILGQTLDA RTVMKTGLES 3050
    VKSALRAFLD NAAEDLEKTM ENLKQGQFTH TRNQPKGVTQ IINYTTVALL 3100
    PMLSSLFEHI GQHQFGEDLI LEDVQVSCYR ILTSLYALGT SKSIYVERQR 3150
    SALGECLAAF AGAFPVAFLE THLDKHNIYS IYNTKSSRER AALSLPTNVE 3200
    DVCPNIPSLE KLMEEIVELA ESGIRYTQMP HVMEVILPML CSYMSRWWEH 3250
    GPENNPERAE MCCTALNSEH MNTLLGNILK IIYNNLGIDE GAWMKRLAVF 3300
    SQPIINKVKP QLLKTHFLPL MEKLKKKAAT VVSEEDHLKA EARGDMSEAE 3350
    LLILDEFTTL ARDLYAFYPL LIRFVDYNRA KWLKEPNPEA EELFRMVAEV 3400
    FIYWSKSHNF KREEQNFVVQ NEINNMSFLI TDTKSKMSKA AVSDQERKKM 3450
    KRKGDRYSMQ TSLIVAALKR LLPIGLNICA PGDQELIALA KNRFSLKDTE 3500
    DEVRDIIRSN IHLQGKLEDP AIRWQMALYK DLPNRTDDTS DPEKTVERVL 3550
    DIANVLFHLE QKSKRVGRRH YCLVEHPQRS KKAVWHKLLS KQRKRAVVAC 3600
    FRMAPLYNLP RHRAVNLFLQ GYEKSWIETE EHYFEDKLIE DLAKPGAEPP 3650
    EEDEGTKRVD PLHQLILLFS RTALTEKCKL EEDFLYMAYA DIMAKSCHDE 3700
    EDDDGEEEVK SFEVTGSQRS KEKEMEKQKL LYQQARLHDR GAAEMVLQTI 3750
    SASKGETGPM VAATLKLGIA ILNGGNSTVQ QKMLDYLKEK KDVGFFQSLA 3800
    GLMQSCSVLD LNAFERQNKA EGLGMVTEEG SGEKVLQDDE FTCDLFRFLQ 3850
    LLCEGHNSDF QNYLRTQTGN NTTVNIIIST VDYLLRVQES ISDFYWYYSG 3900
    KDVIDEQGQR NFSKAIQVAK QVFNTLTEYI QGPCTGNQQS LAHSRLWDAV 3950
    VGFLHVFAHM QMKLSQDSSQ IELLKELMDL QKDMVVMLLS MLEGNVVNGT 4000
    IGKQMVDMLV ESSNNVEMIL KFFDMFLKLK DLTSSDTFKE YDPDGKGVIS 4050
    KRDFHKAMES HKHYTQSETE FLLSCAETDE NETLDYEEFV KRFHEPAKDI 4100
    GFNVAVLLTN LSEHMPNDTR LQTFLELAES VLNYFQPFLG RIEIMGSAKR 4150
    IERVYFEISE SSRTQWEKPQ VKESKRQFIF DVVNEGGEKE KMELFVNFCE 4200
    DTIFEMQLAA QISESDLNER SANKEESEKE RPEEQGPRMA FFSILTVRSA 4250
    LFALRYNILT LMRMLSLKSL KKQMKKVKKM TVKDMVTAFF SSYWSIFMTL 4300
    LHFVASVFRG FFRIICSLLL GGSLVEGAKK IKVAELLANM PDPTQDEVRG 4350
    DGEEGERKPL EAALPSEDLT DLKELTEESD LLSDIFGLDL KREGGQYKLI 4400
    PHNPNAGLSD LMSNPVPMPE VQEKFQEQKA KEEEKEEKEE TKSEPEKAEG 4450
    EDGEKEEKAK EDKGKQKLRQ LHTHRYGEPE VPESAFWKKI IAYQQKLLNY 4500
    FARNFYNMRM LALFVAFAIN FILLFYKVST SSVVEGKELP TRSSSENAKV 4550
    TSLDSSSHRI IAVHYVLEES SGYMEPTLRI LAILHTVISF FCIIGYYCLK 4600
    VPLVIFKREK EVARKLEFDG LYITEQPSED DIKGQWDRLV INTQSFPNNY 4650
    WDKFVKRKVM DKYGEFYGRD RISELLGMDK AALDFSDARE KKKPKKDSSL 4700
    SAVLNSIDVK YQMWKLGVVF TDNSFLYLAW YMTMSVLGHY NNFFFAAHLL 4750
    DIAMGFKTLR TILSSVTHNG KQLVLTVGLL AVVVYLYTVV AFNFFRKFYN 4800
    KSEDGDTPDM KCDDMLTCYM FHMYVGVRAG GGIGDEIEDP AGDEYEIYRI 4850
    IFDITFFFFV IVILLAIIQG LIIDAFGELR DQQEQVKEDM ETKCFICGIG 4900
    NDYFDTVPHG FETHTLQEHN LANYLFFLMY LINKDETEHT GQESYVWKMY 4950
    QERCWEFFPA GDCFRKQYED QLN 4973
    Length:4,973
    Mass (Da):565,484
    Last modified:April 18, 2012 - v1
    Checksum:i41C9306078BAFDF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL356773 Genomic DNA. No translation available.
    AL359924 Genomic DNA. No translation available.
    AL365332 Genomic DNA. No translation available.
    AL391809 Genomic DNA. No translation available.
    AL442065 Genomic DNA. No translation available.
    AL445473 Genomic DNA. No translation available.
    AL513130 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000360064; ENSP00000353174; ENSG00000198626.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL356773 Genomic DNA. No translation available.
    AL359924 Genomic DNA. No translation available.
    AL365332 Genomic DNA. No translation available.
    AL391809 Genomic DNA. No translation available.
    AL442065 Genomic DNA. No translation available.
    AL445473 Genomic DNA. No translation available.
    AL513130 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali H7BY35.
    SMRi H7BY35. Positions 65-543, 2699-2903, 3579-3605.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360064 ; ENSP00000353174 ; ENSG00000198626 .

    Organism-specific databases

    HGNCi HGNC:10484. RYR2.
    GenAtlasi Search...

    Phylogenomic databases

    OMAi SKVQPLM.
    PhylomeDBi H7BY35.

    Miscellaneous databases

    ChiTaRSi RYR2. human.
    NextBioi 35528156.

    Gene expression databases

    ArrayExpressi H7BY35.
    Bgeei H7BY35.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.25.10.30. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR008985. ConA-like_lec_gl_sf.
    IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR014821. Ins145_P3_rcpt.
    IPR005821. Ion_trans_dom.
    IPR016093. MIR_motif.
    IPR013662. RIH_assoc-dom.
    IPR000699. RIH_dom.
    IPR013333. Ryan_recept.
    IPR003032. Ryanodine_rcpt.
    IPR015925. Ryanodine_recept-rel.
    IPR009460. Ryanrecept_TM4-6.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view ]
    PANTHERi PTHR13715. PTHR13715. 1 hit.
    Pfami PF08709. Ins145_P3_rec. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF02815. MIR. 1 hit.
    PF08454. RIH_assoc. 1 hit.
    PF06459. RR_TM4-6. 1 hit.
    PF01365. RYDR_ITPR. 2 hits.
    PF02026. RyR. 4 hits.
    PF00622. SPRY. 3 hits.
    [Graphical view ]
    PRINTSi PR00795. RYANODINER.
    SMARTi SM00054. EFh. 2 hits.
    SM00472. MIR. 4 hits.
    SM00449. SPRY. 3 hits.
    [Graphical view ]
    SUPFAMi SSF100909. SSF100909. 2 hits.
    SSF49899. SSF49899. 2 hits.
    SSF82109. SSF82109. 2 hits.
    PROSITEi PS50188. B302_SPRY. 3 hits.
    PS50222. EF_HAND_2. 1 hit.
    PS50919. MIR. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., Porter K.M., Prigmore E.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiH7BY35_HUMAN
    AccessioniPrimary (citable) accession number: H7BY35
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2012
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3