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Protein

Mitochondrial Rho GTPase

Gene

RHOT1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial GTPase involved in mitochondrial trafficking.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Ligandi

CalciumUniRule annotation, GTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial Rho GTPaseUniRule annotation (EC:3.6.5.-UniRule annotation)
Gene namesi
Name:RHOT1Imported
ORF Names:hCG_1991479Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:21168. RHOT1.

Subcellular locationi

  • Mitochondrion outer membrane UniRule annotation; Single-pass type IV membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei571 – 590HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membraneUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000126858.

PTM / Processingi

Proteomic databases

MaxQBiH7BXZ6.
PeptideAtlasiH7BXZ6.
PRIDEiH7BXZ6.

Expressioni

Gene expression databases

BgeeiENSG00000126858.
ExpressionAtlasiH7BXZ6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351132.

Structurei

3D structure databases

ProteinModelPortaliH7BXZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 156MiroInterPro annotationAdd BLAST156
Domaini163 – 198EF-handInterPro annotationAdd BLAST36
Domaini283 – 318EF-handInterPro annotationAdd BLAST36
Domaini391 – 540MiroInterPro annotationAdd BLAST150

Sequence similaritiesi

Belongs to the mitochondrial Rho GTPase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1707. Eukaryota.
ENOG410XRHW. LUCA.
GeneTreeiENSGT00390000014374.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO_dom.
IPR021181. Mt_Rho_GTPase.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF00071. Ras. 1 hit.
[Graphical view]
PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H7BXZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVSEEFPE EVPPRAEEIT IPADVTPERV PTHIVDYSEA EQSDEQLHQE
60 70 80 90 100
ISQANVICIV YAVNNKHSID KVTSRWIPLI NERTDKDSRL PLILVGNKSD
110 120 130 140 150
LVEYSSMETI LPIMNQYTEI ETCVECSAKN LKNISELFYY AQKAVLHPTG
160 170 180 190 200
PLYCPEEKEM KPACIKALTR IFKISDQDND GTLNDAELNF FQRICFNTPL
210 220 230 240 250
APQALEDVKN VVRKHISDGV ADSGLTLKGF LFLHTLFIQR GRHETTWTVL
260 270 280 290 300
RRFGYDDDLD LTPEYLFPLL KIPPDCTTEL NHHAYLFLQS TFDKHDLDRD
310 320 330 340 350
CALSPDELKD LFKVFPYIPW GPDVNNTVCT NERGWITYQG FLSQWTLTTY
360 370 380 390 400
LDVQRCLEYL GYLGYSILTE QESQASAVTV TRDKKIDLQK KQTQRNVFRC
410 420 430 440 450
NVIGVKNCGK SGVLQALLGR NLMRQKKIRE DHKSYYAINT VYVYGQEKYL
460 470 480 490 500
LLHDISESEF LTEAEIICDV VCLVYDVSNP KSFEYCARIF KQHFMDSRIP
510 520 530 540 550
CLIVAAKSDL HEVKQEYSIS PTDFCRKHKM PPPQAFTCNT ADAPSKDIFV
560 570 580 590
KLTTMAMYPH VTQADLKSST FWLRASFGAT VFAVLGFAMY KALLKQR
Length:597
Mass (Da):68,449
Last modified:October 3, 2012 - v2
Checksum:iECF3091D0C31E9DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026620 Genomic DNA. No translation available.
AC116407 Genomic DNA. No translation available.
CH471147 Genomic DNA. Translation: EAW80251.1.
RefSeqiNP_001275684.1. NM_001288755.1.
XP_016880314.1. XM_017024825.1.
UniGeneiHs.655325.

Genome annotation databases

EnsembliENST00000354266; ENSP00000346215; ENSG00000126858.
GeneIDi55288.
UCSCiuc002hhb.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026620 Genomic DNA. No translation available.
AC116407 Genomic DNA. No translation available.
CH471147 Genomic DNA. Translation: EAW80251.1.
RefSeqiNP_001275684.1. NM_001288755.1.
XP_016880314.1. XM_017024825.1.
UniGeneiHs.655325.

3D structure databases

ProteinModelPortaliH7BXZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000351132.

Proteomic databases

MaxQBiH7BXZ6.
PeptideAtlasiH7BXZ6.
PRIDEiH7BXZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354266; ENSP00000346215; ENSG00000126858.
GeneIDi55288.
UCSCiuc002hhb.5. human.

Organism-specific databases

CTDi55288.
HGNCiHGNC:21168. RHOT1.
OpenTargetsiENSG00000126858.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1707. Eukaryota.
ENOG410XRHW. LUCA.
GeneTreeiENSGT00390000014374.

Miscellaneous databases

ChiTaRSiRHOT1. human.
GenomeRNAii55288.

Gene expression databases

BgeeiENSG00000126858.
ExpressionAtlasiH7BXZ6. baseline and differential.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO_dom.
IPR021181. Mt_Rho_GTPase.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF00071. Ras. 1 hit.
[Graphical view]
PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH7BXZ6_HUMAN
AccessioniPrimary (citable) accession number: H7BXZ6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.