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Protein
Submitted name:

Serine/threonine-protein phosphatase 6 regulatory subunit 3

Gene

PPP6R3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine-protein phosphatase 6 regulatory subunit 3Imported
Gene namesi
Name:PPP6R3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1173. PPP6R3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiH7BXH2.
PeptideAtlasiH7BXH2.

Expressioni

Gene expression databases

BgeeiH7BXH2.
ExpressionAtlasiH7BXH2. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiH7BXH2. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliH7BXH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000009899.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007587. SAPS.
[Graphical view]
PANTHERiPTHR12634. PTHR12634. 1 hit.
PfamiPF04499. SAPS. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

H7BXH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFWKFDLHSS SHIDTLLERE DVTLKELMDE EDVLQECKAQ NRKLIEFLLK
60 70 80 90 100
AECLEDLVSF IIEEPPQDMD EKIRYKYPNI SCELLTSDVS QMNDRLGEDE
110 120 130 140 150
SLLMKLYSFL LNDSPLNPLL ASFFSKVLSI LISRKPEQIV DFLKKKHDFV
160 170 180 190 200
DLIIKHIGTS AIMDLLLRLL TCIEPPQPRQ DVLNWLNEEK IIQRLVEIVH
210 220 230 240 250
PSQEEDRHSN ASQSLCEIVR LSRDQMLQIQ NSTEPDPLLA TLEKQEIIEQ
260 270 280 290 300
LLSNIFHKEK NESAIVSAIQ ILLTLLETRR PTFEGHIEIC PPGMSHSACS
310 320 330 340 350
VNKSVLEAIR GRLGSFHELL LEPPKKSVMK TTWGVLDPPV GNTRLNVIRL
360 370 380 390 400
ISSLLQTNTS SINGDLMELN SIGVILNMFF KYTWNNFLHT QVEICIALIL
410 420 430 440 450
ASPFENTENA TITDQDSTGD NLLLKHLFQK CQLIERILEA WEMNEKKQAE
460 470 480 490 500
GGRRHGYMGH LTRIANCIVH STDKGPNSAL VQQLIKDLPD EVRERWETFC
510 520 530 540 550
TSSLGETNKR NTVDLFGFND EKFADQDDIG NVSFDRVSDI NFTLNTNESG
560 570 580 590 600
NIALFEACCK ERIQQFDDGG SDEEDIWEEK HIAFTPESQR RSSSGSTDSE
610 620 630 640 650
ESTDSEEEDG AKQDLFEPSS ANTEDKMEVD LSEPPNWSAN FDVPMETTHG
660 670 680 690 700
APLDSVGSDV WSTEEPMPTK ETGWASFSEF TSSLSTKDSL RSNSPVEMET
710 720 730 740 750
STEPMDPLTP SAAALAVQPE AAGSVAMEAS SDGEEDAEST DKVTETVMNG
760 770 780 790 800
GMKETLSLTV DAKTETAVFK SEEGKLSTSQ DAACKDAEEC PETAEAKCAA
810 820
PRPPSSSPEQ RTGQPSAPGD TSVNGPV
Length:827
Mass (Da):92,409
Last modified:April 18, 2012 - v1
Checksum:iE99B971D4D4E0B1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000807 Genomic DNA. No translation available.
AP001788 Genomic DNA. No translation available.
AP003096 Genomic DNA. No translation available.
RefSeqiXP_006718684.1. XM_006718621.2.
UniGeneiHs.503022.

Genome annotation databases

EnsembliENST00000265637; ENSP00000265637; ENSG00000110075.
GeneIDi55291.
UCSCiuc001onz.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000807 Genomic DNA. No translation available.
AP001788 Genomic DNA. No translation available.
AP003096 Genomic DNA. No translation available.
RefSeqiXP_006718684.1. XM_006718621.2.
UniGeneiHs.503022.

3D structure databases

ProteinModelPortaliH7BXH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiH7BXH2. 2 interactions.

Proteomic databases

EPDiH7BXH2.
PeptideAtlasiH7BXH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265637; ENSP00000265637; ENSG00000110075.
GeneIDi55291.
UCSCiuc001onz.4. human.

Organism-specific databases

CTDi55291.
HGNCiHGNC:1173. PPP6R3.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000009899.

Miscellaneous databases

ChiTaRSiPPP6R3. human.
GenomeRNAii55291.

Gene expression databases

BgeeiH7BXH2.
ExpressionAtlasiH7BXH2. baseline and differential.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007587. SAPS.
[Graphical view]
PANTHERiPTHR12634. PTHR12634. 1 hit.
PfamiPF04499. SAPS. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  13. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiH7BXH2_HUMAN
AccessioniPrimary (citable) accession number: H7BXH2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: July 6, 2016
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.