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H7BXC3

- H7BXC3_MOUSE

UniProt

H7BXC3 - H7BXC3_MOUSE

Protein

Triosephosphate isomerase

Gene

Tpi1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalytic activityi

    D-glyceraldehyde 3-phosphate = glycerone phosphate.

    Pathwayi

    GO - Molecular functioni

    1. isomerase activity Source: MGI
    2. triose-phosphate isomerase activity Source: MGI

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-UniPathway
    2. glucose metabolic process Source: MGI
    3. glycolytic process Source: MGI
    4. multicellular organismal development Source: MGI

    Keywords - Molecular functioni

    IsomeraseUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00189.
    UPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
    Gene namesi
    Name:Tpi1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:98797. Tpi1.

    Expressioni

    Gene expression databases

    ArrayExpressiH7BXC3.
    BgeeiH7BXC3.

    Structurei

    3D structure databases

    ProteinModelPortaliH7BXC3.
    SMRiH7BXC3. Positions 1-167.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the triosephosphate isomerase family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000013354.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000652. Triosephosphate_isomerase.
    IPR020861. Triosephosphate_isomerase_AS.
    [Graphical view]
    PANTHERiPTHR21139. PTHR21139. 1 hit.
    PfamiPF00121. TIM. 1 hit.
    [Graphical view]
    SUPFAMiSSF51351. SSF51351. 1 hit.
    TIGRFAMsiTIGR00419. tim. 1 hit.
    PROSITEiPS00171. TIM_1. 1 hit.
    PS51440. TIM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H7BXC3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKDLGATWV VLGHSERRHV FGESDELIGQ KVSHALAEGL GVIACIGEKL    50
    DEREAGITEK VVFEQTKVIA DNVKDWSKVV LAYEPVWAIG TGKTATPQQA 100
    QEVHEKLRGW LKSNVNDGVA QSTRIIYGGS VTGATCKELA SQPDVDGFLV 150
    GGASLKPEFV DIINAKQ 167
    Length:167
    Mass (Da):17,997
    Last modified:April 18, 2012 - v1
    Checksum:i0478BB3AD92AD902
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC142254 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000149610; ENSMUSP00000125292; ENSMUSG00000023456.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC142254 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali H7BXC3.
    SMRi H7BXC3. Positions 1-167.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000149610 ; ENSMUSP00000125292 ; ENSMUSG00000023456 .

    Organism-specific databases

    MGIi MGI:98797. Tpi1.

    Phylogenomic databases

    GeneTreei ENSGT00390000013354.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00189 .
    UPA00138 .

    Miscellaneous databases

    ChiTaRSi TPI1. mouse.
    NextBioi 35562304.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi H7BXC3.
    Bgeei H7BXC3.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000652. Triosephosphate_isomerase.
    IPR020861. Triosephosphate_isomerase_AS.
    [Graphical view ]
    PANTHERi PTHR21139. PTHR21139. 1 hit.
    Pfami PF00121. TIM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51351. SSF51351. 1 hit.
    TIGRFAMsi TIGR00419. tim. 1 hit.
    PROSITEi PS00171. TIM_1. 1 hit.
    PS51440. TIM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiH7BXC3_MOUSE
    AccessioniPrimary (citable) accession number: H7BXC3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2012
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3