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Protein

Triosephosphate isomerase

Gene

Tpi1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (Tpi1), Triosephosphate isomerase (Tpi1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotation
Biological processGluconeogenesisUniRule annotation, GlycolysisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Gene namesi
Name:Tpi1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:98797 Tpi1

PTM / Processingi

Proteomic databases

MaxQBiH7BXC3
PeptideAtlasiH7BXC3
PRIDEiH7BXC3

Expressioni

Gene expression databases

BgeeiENSMUSG00000023456
ExpressionAtlasiH7BXC3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH7BXC3
SMRiH7BXC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1643 Eukaryota
COG0149 LUCA
GeneTreeiENSGT00390000013354

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

H7BXC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKDLGATWV VLGHSERRHV FGESDELIGQ KVSHALAEGL GVIACIGEKL
60 70 80 90 100
DEREAGITEK VVFEQTKVIA DNVKDWSKVV LAYEPVWAIG TGKTATPQQA
110 120 130 140 150
QEVHEKLRGW LKSNVNDGVA QSTRIIYGGS VTGATCKELA SQPDVDGFLV
160
GGASLKPEFV DIINAKQ
Length:167
Mass (Da):17,997
Last modified:April 18, 2012 - v1
Checksum:i0478BB3AD92AD902
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC142254 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000149610; ENSMUSP00000125292; ENSMUSG00000023456

Similar proteinsi

Entry informationi

Entry nameiH7BXC3_MOUSE
AccessioniPrimary (citable) accession number: H7BXC3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: April 25, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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