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H7BXC3

- H7BXC3_MOUSE

UniProt

H7BXC3 - H7BXC3_MOUSE

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Protein

Triosephosphate isomerase

Gene

Tpi1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. isomerase activity Source: MGI
  2. triose-phosphate isomerase activity Source: MGI

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-UniPathway
  2. glucose metabolic process Source: MGI
  3. glycolytic process Source: MGI
  4. multicellular organismal development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Gene namesi
Name:Tpi1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:98797. Tpi1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiH7BXC3.
ExpressionAtlasiH7BXC3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH7BXC3.
SMRiH7BXC3. Positions 1-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000013354.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H7BXC3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKDLGATWV VLGHSERRHV FGESDELIGQ KVSHALAEGL GVIACIGEKL
60 70 80 90 100
DEREAGITEK VVFEQTKVIA DNVKDWSKVV LAYEPVWAIG TGKTATPQQA
110 120 130 140 150
QEVHEKLRGW LKSNVNDGVA QSTRIIYGGS VTGATCKELA SQPDVDGFLV
160
GGASLKPEFV DIINAKQ
Length:167
Mass (Da):17,997
Last modified:April 18, 2012 - v1
Checksum:i0478BB3AD92AD902
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC142254 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000149610; ENSMUSP00000125292; ENSMUSG00000023456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC142254 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali H7BXC3.
SMRi H7BXC3. Positions 1-167.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000149610 ; ENSMUSP00000125292 ; ENSMUSG00000023456 .

Organism-specific databases

MGIi MGI:98797. Tpi1.

Phylogenomic databases

GeneTreei ENSGT00390000013354.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00189 .
UPA00138 .

Miscellaneous databases

ChiTaRSi TPI1. mouse.
NextBioi 35562304.
SOURCEi Search...

Gene expression databases

Bgeei H7BXC3.
ExpressionAtlasi H7BXC3. baseline and differential.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view ]
PANTHERi PTHR21139. PTHR21139. 1 hit.
Pfami PF00121. TIM. 1 hit.
[Graphical view ]
SUPFAMi SSF51351. SSF51351. 1 hit.
TIGRFAMsi TIGR00419. tim. 1 hit.
PROSITEi PS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiH7BXC3_MOUSE
AccessioniPrimary (citable) accession number: H7BXC3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: October 29, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3