ID   H7BX92_MOUSE            Unreviewed;      1489 AA.
AC   H7BX92;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   SubName: Full=Adhesion G protein-coupled receptor B2 {ECO:0000313|Ensembl:ENSMUSP00000101639.3};
GN   Name=Adgrb2 {ECO:0000313|Ensembl:ENSMUSP00000101639.3,
GN   ECO:0000313|MGI:MGI:2451244};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000101639.3, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0007829|PubMed:18034455}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18034455; DOI=10.1021/pr0701254;
RA   Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
RT   "Large-scale identification and evolution indexing of tyrosine
RT   phosphorylation sites from murine brain.";
RL   J. Proteome Res. 7:311-318(2008).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000101639.3, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000101639.3,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000101639.3}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000101639.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   SMR; H7BX92; -.
DR   MaxQB; H7BX92; -.
DR   ProteomicsDB; 320543; -.
DR   Antibodypedia; 16794; 330 antibodies from 33 providers.
DR   Ensembl; ENSMUST00000106018.9; ENSMUSP00000101639.3; ENSMUSG00000028782.15.
DR   AGR; MGI:2451244; -.
DR   MGI; MGI:2451244; Adgrb2.
DR   VEuPathDB; HostDB:ENSMUSG00000028782; -.
DR   GeneTree; ENSGT00940000160103; -.
DR   ChiTaRS; Adgrb2; mouse.
DR   Proteomes; UP000000589; Chromosome 4.
DR   Bgee; ENSMUSG00000028782; Expressed in primary visual cortex and 135 other cell types or tissues.
DR   ExpressionAtlas; H7BX92; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR   Gene3D; 1.25.40.610; -; 1.
DR   Gene3D; 2.60.220.50; -; 1.
DR   Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR   InterPro; IPR043838; AGRB_N.
DR   InterPro; IPR032471; GAIN_dom_N.
DR   InterPro; IPR046338; GAIN_dom_sf.
DR   InterPro; IPR017981; GPCR_2-like_7TM.
DR   InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR000203; GPS.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR10239:SF32; ADHESION G PROTEIN-COUPLED RECEPTOR B2; 1.
DR   PANTHER; PTHR10239; ISTHMIN-2; 1.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF19188; AGRB_N; 1.
DR   Pfam; PF16489; GAIN; 1.
DR   Pfam; PF01825; GPS; 1.
DR   Pfam; PF02793; HRM; 1.
DR   Pfam; PF00090; TSP_1; 3.
DR   PRINTS; PR01694; BAIPRECURSOR.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00303; GPS; 1.
DR   SMART; SM00008; HormR; 1.
DR   SMART; SM00209; TSP1; 3.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
DR   PROSITE; PS50092; TSP1; 3.
PE   1: Evidence at protein level;
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|MaxQB:H7BX92,
KW   ECO:0007829|PeptideAtlas:H7BX92}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..1489
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030172772"
FT   TRANSMEM        875..896
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        908..929
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        941..965
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        977..995
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1015..1038
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1059..1081
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          457..527
FT                   /note="G-protein coupled receptors family 2 profile 1"
FT                   /evidence="ECO:0000259|PROSITE:PS50227"
FT   DOMAIN          871..1112
FT                   /note="G-protein coupled receptors family 2 profile 2"
FT                   /evidence="ECO:0000259|PROSITE:PS50261"
FT   REGION          702..742
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1267..1289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1330..1359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1426..1489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1442..1456
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1489 AA;  162633 MW;  AEB78464AFD52F2D CRC64;
     MTPACPLLLS VILSLRLATA FDPAPSACSA LASGVLYGAF SLQDLFPTIA SGCSWTLENP
     DPTKYSLYLR FNRQEQVCTH FAPRLLPLDH YLVNFTCLRP GPEEATARAE SEVGRPEEEE
     EEAAAAASGL ELCGGSGPFT FLHFDKNFVQ LCLSAEPSEA PRLLAPAALA FRFVEVLLIN
     NNNSSQFTCG VLCRWSEECG RAAGRACGFA QPGCSCPGEA GANPATTTSP GPPVAHTLSN
     ALVPGGPAPP AEADLHSGSS NDLFTTEMRY GEEPEEEPKV KTQWPRSADE PGLYMAQTVH
     GVWEEWGSWS LCSRSCGRGS RSRMRTCVPP QHGGKACEGP ELQTKLCSMA ACPVEGQWLE
     WGPWGPCSSS CANGTQQRSR KCSVAGPAWA TCAGALTDTR ECSNLDCPAT DGKWGPWNAW
     SLCSKTCDTG WQRRFRMCQA SGTQGYPCEG TGEEVKPCSE KRCPAFHEMC RDEYVMLMTW
     KRAAAGEIIY NKCPPNASGS ASRRCLLSAQ GVAYWGLPSF ARCISHEYRY LYLSLREHLA
     KGQRMLAGEG MSQVVRSLQE LLARRTYYSG DLLFSVDILR NVTDTFKRAT YVPSADDVQR
     FFQVVSFMVD SENKDKWDDA QQVSPGSVHL LRVVEDFIHL VGDALKAFQS SLIVTDNLVI
     SIQREPISAV SSDITFPMRG RRGMKDWVRH SEDRLFLPKE VLSLSSPGKP ATPGAATAGS
     PGRGRGPGTV PPGPGHAHQR LLPADPEESS SYFVIGAVLY RTLGLILPPP RPPLAVTSRV
     MTVTVRPPTQ PPAEPLITVE LSYIINGTTD PHCASWDYSR ADTNSGDWNT ESCQTLETQA
     AHTRCQCQHL STFAVLAQPP KDLTLELAGA PSVPLVIGCA VSCMALLTLL AIYAAFWRFI
     KSERSIILLN FCLSILASNI LILVGQSRVL SKGVCTMTAA FLHFFFLSSF CWVLTEAWQS
     YLAVIGRMRT RLVRKRFLCL GWGLPALVVA VSVGFTRTKG YGTSSYCWLS LEGGLLYAFV
     GPAAVIVLVN MLIGIIVFNK LMARDGVSDK SKKQRAGASL WSSCVVLPLL ALTWMSAVLA
     MTDRRSVLFQ ALFAVFNSAQ GFVITAVHCF LRREVQDVVK CQMGVCRADE SEDSPDSCKN
     GQLQILSDFE KDVDLACQTV LFKEVNTCNP STITGTLSRL SLDEDEEPKS CLVGPEGGLS
     FSPLPGNILV PMAASPGLGE PPPPQETNPV YMCGEGGLRQ LDLTWIRQSE PGSEGDYMVL
     PRRTLSLQPG GGGTAGEEAP RARPEGTPRR AAKTVAHTEG YPSFLSVEHS GLGLGPAYGS
     LQNPYGMTFQ PPPPTPSARQ VPEPGERSRT MPRTVPGSTM KLGSLERKKL RYSDLDFEKV
     MHTRKRHSEL YHELNQKFHT FDRYRSQSSA KVRWMRGCNR LALLLSQEKP SPPGGRPGLS
     QHRRHQSWST FKSMTLGSLP PKPRERLALH RTAAWEPTEP PDGDFQTEV
//