ID   H6UYS5_HUMAN            Unreviewed;       112 AA.
AC   H6UYS5;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 76.
DE   RecName: Full=Alpha-synuclein {ECO:0000256|ARBA:ARBA00017952, ECO:0000256|RuleBase:RU361225};
GN   Name=SNCA {ECO:0000313|EMBL:AFA25674.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AFA25674.1};
RN   [1] {ECO:0000313|EMBL:AFA25674.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:AFA25674.1};
RA   Beyer K., Munoz-Marmol A.M.;
RT   "SNCA transcript variants can be classified into four groups in dependence
RT   on their initial exon.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell projection, axon
CC       {ECO:0000256|ARBA:ARBA00004489}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}. Synapse
CC       {ECO:0000256|ARBA:ARBA00034103}.
CC   -!- SIMILARITY: Belongs to the synuclein family.
CC       {ECO:0000256|ARBA:ARBA00009147, ECO:0000256|RuleBase:RU361225}.
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DR   EMBL; JN709861; AFA25671.1; -; mRNA.
DR   EMBL; JN709864; AFA25674.1; -; mRNA.
DR   EMBL; JN709867; AFA25677.1; -; mRNA.
DR   RefSeq; NP_009292.1; NM_007308.2.
DR   AlphaFoldDB; H6UYS5; -.
DR   Antibodypedia; 14688; 3537 antibodies from 55 providers.
DR   DNASU; 6622; -.
DR   GeneID; 6622; -.
DR   CTD; 6622; -.
DR   VEuPathDB; HostDB:ENSG00000145335; -.
DR   HOGENOM; CLU_129378_1_0_1; -.
DR   OrthoDB; 5321875at2759; -.
DR   BioGRID-ORCS; 6622; 12 hits in 1150 CRISPR screens.
DR   ChiTaRS; SNCA; human.
DR   GenomeRNAi; 6622; -.
DR   ExpressionAtlas; H6UYS5; baseline and differential.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0014059; P:regulation of dopamine secretion; IEA:InterPro.
DR   Gene3D; 1.10.287.700; Helix hairpin bin; 1.
DR   InterPro; IPR001058; Synuclein.
DR   InterPro; IPR002460; Synuclein_alpha.
DR   PANTHER; PTHR13820:SF5; ALPHA-SYNUCLEIN; 1.
DR   PANTHER; PTHR13820; SYNUCLEIN; 1.
DR   Pfam; PF01387; Synuclein; 1.
DR   PRINTS; PR01212; ASYNUCLEIN.
DR   PRINTS; PR01211; SYNUCLEIN.
DR   SUPFAM; SSF118375; Synuclein; 1.
PE   2: Evidence at transcript level;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018}.
SQ   SEQUENCE   112 AA;  11372 MW;  16EA234777EFA89E CRC64;
     MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK
     EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKEGYQDYEP EA
//