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H6UYS5

- H6UYS5_HUMAN

UniProt

H6UYS5 - H6UYS5_HUMAN

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Protein

Alpha-synuclein

Gene

SNCA

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. regulation of dopamine secretion Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-synucleinUniRule annotation
Gene namesi
Name:SNCAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiH6UYS5.

Expressioni

Gene expression databases

BgeeiH6UYS5.
ExpressionAtlasiH6UYS5. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH6UYS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the synuclein family.UniRule annotation

Phylogenomic databases

KOiK04528.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01212. ASYNUCLEIN.
PR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Complete.

H6UYS5-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH
60 70 80 90 100
GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL
110
GKEGYQDYEP EA
Length:112
Mass (Da):11,372
Last modified:April 18, 2012 - v1
Checksum:i16EA234777EFA89E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN709861 mRNA. Translation: AFA25671.1.
JN709864 mRNA. Translation: AFA25674.1.
JN709867 mRNA. Translation: AFA25677.1.
RefSeqiNP_009292.1. NM_007308.2.
UniGeneiHs.21374.

Genome annotation databases

GeneIDi6622.
KEGGihsa:6622.
UCSCiuc003hso.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN709861 mRNA. Translation: AFA25671.1 .
JN709864 mRNA. Translation: AFA25674.1 .
JN709867 mRNA. Translation: AFA25677.1 .
RefSeqi NP_009292.1. NM_007308.2.
UniGenei Hs.21374.

3D structure databases

ProteinModelPortali H6UYS5.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi H6UYS5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6622.
KEGGi hsa:6622.
UCSCi uc003hso.3. human.

Organism-specific databases

CTDi 6622.

Phylogenomic databases

KOi K04528.

Miscellaneous databases

ChiTaRSi SNCA. human.
GenomeRNAii 6622.
NextBioi 25791.

Gene expression databases

Bgeei H6UYS5.
ExpressionAtlasi H6UYS5. baseline and differential.

Family and domain databases

Gene3Di 1.10.287.700. 1 hit.
InterProi IPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view ]
PANTHERi PTHR13820. PTHR13820. 1 hit.
Pfami PF01387. Synuclein. 1 hit.
[Graphical view ]
PRINTSi PR01212. ASYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNeti Search...

Publicationsi

  1. "SNCA transcript variants can be classified into four groups in dependence on their initial exon."
    Beyer K., Munoz-Marmol A.M.
    Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiH6UYS5_HUMAN
AccessioniPrimary (citable) accession number: H6UYS5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: November 26, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.