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Protein

Alpha-synuclein

Gene

SNCA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-synucleinUniRule annotation
Gene namesi
Name:SNCAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiH6UYS5.

Expressioni

Gene expression databases

BgeeiH6UYS5.
ExpressionAtlasiH6UYS5. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH6UYS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the synuclein family.UniRule annotation

Phylogenomic databases

KOiK04528.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01212. ASYNUCLEIN.
PR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Complete.

H6UYS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH
60 70 80 90 100
GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL
110
GKEGYQDYEP EA
Length:112
Mass (Da):11,372
Last modified:April 18, 2012 - v1
Checksum:i16EA234777EFA89E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN709861 mRNA. Translation: AFA25671.1.
JN709864 mRNA. Translation: AFA25674.1.
JN709867 mRNA. Translation: AFA25677.1.
RefSeqiNP_009292.1. NM_007308.2.
UniGeneiHs.21374.

Genome annotation databases

GeneIDi6622.
KEGGihsa:6622.
UCSCiuc003hso.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN709861 mRNA. Translation: AFA25671.1.
JN709864 mRNA. Translation: AFA25674.1.
JN709867 mRNA. Translation: AFA25677.1.
RefSeqiNP_009292.1. NM_007308.2.
UniGeneiHs.21374.

3D structure databases

ProteinModelPortaliH6UYS5.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiH6UYS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6622.
KEGGihsa:6622.
UCSCiuc003hso.3. human.

Organism-specific databases

CTDi6622.

Phylogenomic databases

KOiK04528.

Miscellaneous databases

ChiTaRSiSNCA. human.
GenomeRNAii6622.
NextBioi25791.

Gene expression databases

BgeeiH6UYS5.
ExpressionAtlasiH6UYS5. baseline and differential.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01212. ASYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNetiSearch...

Publicationsi

  1. "SNCA transcript variants can be classified into four groups in dependence on their initial exon."
    Beyer K., Munoz-Marmol A.M.
    Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiH6UYS5_HUMAN
AccessioniPrimary (citable) accession number: H6UYS5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: April 29, 2015
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.