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Protein

Alpha-synuclein

Gene

SNCA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. regulation of dopamine secretion Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-synucleinUniRule annotation
Gene namesi
Name:SNCAImported
ORF Names:hCG_1777783Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiH6UYS0.

Expressioni

Gene expression databases

BgeeiH6UYS0.
ExpressionAtlasiH6UYS0. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH6UYS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the synuclein family.UniRule annotation

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01212. ASYNUCLEIN.
PR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Complete.

H6UYS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV VAEKTKEQVT
60 70 80 90 100
NVGGAVVTGV TAVAQKTVEG AGSIAAATGF VKKDQLGKNE EGAPQEGILE
110 120
DMPVDPDNEA YEMPSEEGYQ DYEPEA
Length:126
Mass (Da):13,109
Last modified:April 18, 2012 - v1
Checksum:i0F87D9A60E831E02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN709859 mRNA. Translation: AFA25669.1.
JN709862 mRNA. Translation: AFA25672.1.
JN709865 mRNA. Translation: AFA25675.1.
JN709868 mRNA. Translation: AFA25678.1.
CH471057 Genomic DNA. Translation: EAX06035.1.
UniGeneiHs.21374.

Genome annotation databases

UCSCiuc010ikt.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN709859 mRNA. Translation: AFA25669.1.
JN709862 mRNA. Translation: AFA25672.1.
JN709865 mRNA. Translation: AFA25675.1.
JN709868 mRNA. Translation: AFA25678.1.
CH471057 Genomic DNA. Translation: EAX06035.1.
UniGeneiHs.21374.

3D structure databases

ProteinModelPortaliH6UYS0.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiH6UYS0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc010ikt.4. human.

Miscellaneous databases

ChiTaRSiSNCA. human.
NextBioi35527923.

Gene expression databases

BgeeiH6UYS0.
ExpressionAtlasiH6UYS0. baseline and differential.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01212. ASYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNetiSearch...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "SNCA transcript variants can be classified into four groups in dependence on their initial exon."
    Beyer K., Munoz-Marmol A.M.
    Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiH6UYS0_HUMAN
AccessioniPrimary (citable) accession number: H6UYS0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: April 1, 2015
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.