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H6SKP9 (H6SKP9_RHOPH) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-isopropylmalate synthase HAMAP-Rule MF_00572
EC=2.3.3.13 HAMAP-Rule MF_00572
Alternative name(s):
Alpha-IPM synthase HAMAP-Rule MF_00572
Alpha-isopropylmalate synthase HAMAP-Rule MF_00572
Gene names
Name:leuA HAMAP-Rule MF_00572
ORF Names:RSPPHO_01938 EMBL CCG08564.1
OrganismRhodospirillum photometricum DSM 122 EMBL CCG08564.1
Taxonomic identifier1150469 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Rhodospirillum ›

Protein attributes

Sequence length568 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) By similarity. HAMAP-Rule MF_00572

Catalytic activity

Acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA. HAMAP-Rule MF_00572

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4. HAMAP-Rule MF_00572 SAAS SAAS005668

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00572

Sequence similarities

Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. HAMAP-Rule MF_00572

Sequences

Sequence LengthMass (Da)Tools
H6SKP9 [UniParc].

Last modified April 18, 2012. Version 1.
Checksum: AA076605348EE866

FASTA56861,813
        10         20         30         40         50         60 
MGVFPTDILR CAMLKTPAVK YPPFLPPTYP DRTWPDRRLE RAPRWCSTDL RDGNQALVEP 

        70         80         90        100        110        120 
MDLARKNRLY DLLVRLGFKE IEVAFPAASA VEQAFVRSLI DDNRIPADVT LQVMTPARPP 

       130        140        150        160        170        180 
LIATTIAALA GAPRAIVHLY NATAPLFRRV VFGLDQTQTV ALAVEGTRLI RELTEARPET 

       190        200        210        220        230        240 
RWTYQYSPET FCFTEWEFAL EICERVRETW GPTAERPLIL NLPTTVEVAM PNAFADQIEW 

       250        260        270        280        290        300 
FHRHLSSREH VTLSVHPHND RGTAVATAEQ ALLAGAERIE GCLFGNGERT GNVDLLTLAL 

       310        320        330        340        350        360 
NLYTQGIDPG LDFSALDEVK EVLEWCTGLP VPARHPYAGA LVYTAFSGSH QDAIRKGFAA 

       370        380        390        400        410        420 
REARGEARWE IPYLPLDPAD VGRSYEAVIR VNSQSGKGGA AWVVERALGV SLPKGLQADF 

       430        440        450        460        470        480 
GRRVQALADA QGGELDAEAV CALFARAYFV EDSPALRLID HHLSRDGETC VFRGTVSRGQ 

       490        500        510        520        530        540 
EPPYAVEGRG NGSLSSALAA LASVGVCLSV RAFSEQSLER GAEARAIAFL EAEAAGGRSV 

       550        560 
FGVGLDTDTT LAALRAVVSA ANAVLGDA

« Hide

References

[1]"Shotgun genome sequence of Phaeospirillum photometricum DSM 122."
Duquesne K., Sturgis J.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: DSM 122 EMBL CCG08564.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		HE663493 Genomic DNA. Translation: CCG08564.1.
RefSeqYP_005417534.1. NC_017059.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCG08564; CCG08564; RSPPHO_01938.
GeneID12212627.
KEGGrpm:RSPPHO_01938.

Phylogenomic databases

KOK01649.

Enzyme and pathway databases

BioCycRPHO1150469:GLJ6-2050-MONOMER.
UniPathwayUPA00048; UER00070.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00572. LeuA_type2.
InterProIPR013709. 2-isopropylmalate_synth_dimer.
IPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR005668. IPM_Synthase.
IPR000891. PYR_CT.
[Graphical view]
PfamPF00682. HMGL-like. 1 hit.
PF08502. LeuA_dimer. 1 hit.
[Graphical view]
SMARTSM00917. LeuA_dimer. 1 hit.
[Graphical view]
SUPFAMSSF110921. 2-isopropylmalate_synth_dimer. 1 hit.
TIGRFAMsTIGR00970. leuA_yeast. 1 hit.
PROSITEPS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH6SKP9_RHOPH
AccessionPrimary (citable) accession number: H6SKP9
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: May 29, 2013
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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