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H6SII4 (H6SII4_RHOPH) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine--tRNA ligase HAMAP-Rule MF_00176
EC=6.1.1.11 HAMAP-Rule MF_00176
Alternative name(s):
Seryl-tRNA synthetase HAMAP-Rule MF_00176
Seryl-tRNA(Ser/Sec) synthetase HAMAP-Rule MF_00176
Gene names
Name:serS HAMAP-Rule MF_00176 EMBL CCG06750.1
ORF Names:RSPPHO_00124 EMBL CCG06750.1
OrganismRhodospirillum photometricum DSM 122 EMBL CCG06750.1
Taxonomic identifier1150469 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Rhodospirillum ›

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) By similarity. HAMAP-Rule MF_00176

Catalytic activity

ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec). HAMAP-Rule MF_00176

ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). HAMAP-Rule MF_00176

Pathway

Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1. HAMAP-Rule MF_00176

Subunit structure

Homodimer. The tRNA molecule binds across the dimer By similarity. HAMAP-Rule MF_00176

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00176.

Domain

Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding By similarity. HAMAP-Rule MF_00176

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. HAMAP-Rule MF_00176

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding269 – 2713ATP By similarity HAMAP-Rule MF_00176
Nucleotide binding356 – 3594ATP By similarity HAMAP-Rule MF_00176
Region238 – 2403Serine binding By similarity HAMAP-Rule MF_00176

Sites

Binding site2921Serine By similarity HAMAP-Rule MF_00176
Binding site3921Serine By similarity HAMAP-Rule MF_00176

Sequences

Sequence LengthMass (Da)Tools
H6SII4 [UniParc].

Last modified April 18, 2012. Version 1.
Checksum: AC0899D93864E34D

FASTA43247,220
        10         20         30         40         50         60 
MFCLQGFLIM HDLKVIRDTP AAFDAALARR GIAPVADALL ALDQQRRAAQ TALNDMQARR 

        70         80         90        100        110        120 
NEVSRAIGDI RKAGGTAEAE TQEVAALKAR MSETEDEVRR LGEALDQQLL TLPNRVDDTV 

       130        140        150        160        170        180 
PDGSDETANV EVRRWGTPRA FDFAVRDHVD LGQGLDGMDF EAAARLSGAR FVVLKGALAR 

       190        200        210        220        230        240 
LERALAQYML DLHITEHAYT EVQTPALVRE PALLGTGQLP KFAEDLFRLE QGYYLIPTAE 

       250        260        270        280        290        300 
VTLTNLVNGQ ILPLSALPLR MTALTQCFRA EAGAAGRDTR GMIRQHQFEK VEMVSIVAPE 

       310        320        330        340        350        360 
DSDAELERMT GCAEAVLQGL GLPYRVVALC SGDIGFSARK TYDLEVWLPA QGCYREISSC 

       370        380        390        400        410        420 
SNTGDFQARR MNARFKVEGE KGTRFVHTLN GSGLAVGRTL VAVLENYQNA DGSVSVPPVL 

       430 
RPYMGGLERI GS

« Hide

References

[1]"Shotgun genome sequence of Phaeospirillum photometricum DSM 122."
Duquesne K., Sturgis J.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: DSM 122 EMBL CCG06750.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		HE663493 Genomic DNA. Translation: CCG06750.1.
RefSeqYP_005415720.1. NC_017059.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCG06750; CCG06750; RSPPHO_00124.
GeneID12210824.
KEGGrpm:RSPPHO_00124.

Phylogenomic databases

KOK01875.

Enzyme and pathway databases

UniPathwayUPA00906; UER00895.

Family and domain databases

Gene3D1.10.287.40. 1 hit.
HAMAPMF_00176. Ser_tRNA_synth_type1.
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR002317. Ser-tRNA-ligase_type_1.
IPR015866. Ser-tRNA-synth_1_N.
IPR010978. tRNA-bd_arm.
[Graphical view]
PANTHERPTHR11778. PTHR11778. 1 hit.
PfamPF02403. Seryl_tRNA_N. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PIRSFPIRSF001529. Ser-tRNA-synth_IIa. 1 hit.
PRINTSPR00981. TRNASYNTHSER.
SUPFAMSSF46589. tRNA_binding_arm. 1 hit.
TIGRFAMsTIGR00414. serS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH6SII4_RHOPH
AccessionPrimary (citable) accession number: H6SII4
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: April 3, 2013
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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