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Protein

Cytochrome c oxidase subunit 6A, mitochondrial

Gene

COX6A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6A, mitochondrialUniRule annotation
Alternative name(s):
Cytochrome c oxidase polypeptide VIaUniRule annotation
Gene namesi
Name:COX6A1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiH6SG15.

Expressioni

Gene expression databases

BgeeiH6SG15.
ExpressionAtlasiH6SG15. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000229379.

Structurei

3D structure databases

ProteinModelPortaliH6SG15.
SMRiH6SG15. Positions 25-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 6A family.UniRule annotation

Phylogenomic databases

KOiK02266.
OMAiNAYLKHQ.
PhylomeDBiH6SG15.

Family and domain databases

Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H6SG15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVGVSSVS RLLGRSRPQL GRPMSSGAHG EEGSARMWKT LTFFVALPGV
60 70 80 90 100
AVSMLNVYLK SHHGEHERPE FIAYPHLRIR TKPFPWGDGN HTLFHNPHVN

PLPTGYEDE
Length:109
Mass (Da):12,155
Last modified:April 18, 2012 - v1
Checksum:i0040F47CECE767B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE647860 mRNA. Translation: CCF23108.1.
RefSeqiNP_004364.2. NM_004373.3.
UniGeneiHs.369624.

Genome annotation databases

GeneIDi1337.
KEGGihsa:1337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE647860 mRNA. Translation: CCF23108.1.
RefSeqiNP_004364.2. NM_004373.3.
UniGeneiHs.369624.

3D structure databases

ProteinModelPortaliH6SG15.
SMRiH6SG15. Positions 25-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000229379.

Proteomic databases

PRIDEiH6SG15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1337.
KEGGihsa:1337.

Organism-specific databases

CTDi1337.

Phylogenomic databases

KOiK02266.
OMAiNAYLKHQ.
PhylomeDBiH6SG15.

Miscellaneous databases

ChiTaRSiCOX6A1. human.
GenomeRNAii1337.
NextBioi5431.

Gene expression databases

BgeeiH6SG15.
ExpressionAtlasiH6SG15. baseline.

Family and domain databases

Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-resolution melting analysis of 15 genes in 60 patients with cytochrome c oxidase deficiency."
    Vondrackova A., Vesela K., Hansikova H., Zajicova Docekalova D., Rozsypalova E., Zeman J., Tesarova M.
    Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Peripheral bloodImported.

Entry informationi

Entry nameiH6SG15_HUMAN
AccessioniPrimary (citable) accession number: H6SG15
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: June 24, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.