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H6S8M7

- H6S8M7_MYCTX

UniProt

H6S8M7 - H6S8M7_MYCTX

Protein

Glutamate decarboxylase

Gene

gadB

Organism
Mycobacterium tuberculosis UT205
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: InterPro
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
    Gene namesi
    Name:gadBImported
    ORF Names:UDA_3432cImported
    OrganismiMycobacterium tuberculosis UT205Imported
    Taxonomic identifieri1097669 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000007521: Chromosome

    PTM / Processingi

    Proteomic databases

    PRIDEiH6S8M7.

    Structurei

    3D structure databases

    ProteinModelPortaliH6S8M7.
    SMRiH6S8M7. Positions 12-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    KOiK01580.
    OMAiPTFQINF.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    H6S8M7-1 [UniParc]FASTAAdd to Basket

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    MSRSHPSVPA HSIAPAYTGR MFTAPVPALR MPDESMDPEA AYRFIHDELM    50
    LDGSSRLNLA TFVTTWMDPE AEKLMAETFD KNMIDKDEYP ATAAIEARCV 100
    SMVADLFHAE GLRDHDPTSA TGVSTIGSSE AVMLGGLALK WRWRQRVGSW 150
    KGRMPNLVMG SNVQVVWEKF CRYFDVEPRY LPMERGRYVI TPEQVLAAVD 200
    ENTIGVVAIL GTTYTGELEP IAEICAALDK LAAGGGVDVP VHVDAASGGF 250
    VVPFLHPDLV WDFRLPRVVS INVSGHKYGL TYPGVGFVVW RGPEHLPEDL 300
    VFRVNYLGGD MPTFTLNFSR PGNQVVGQYY NFLRLGRDGY TKVMQALSHT 350
    ARWLGDQLRE VDHCEVISDG SAIPVVSFRL AGDRGYTEFD VSHELRTFGW 400
    QVPAYTMPDN ATDVAVLRIV VREGLSADLA RALHDDAVTA LAALDKVKPG 450
    GHFDAQHFAH 460
    Length:460
    Mass (Da):50,780
    Last modified:April 18, 2012 - v1
    Checksum:iB5DA3156D4C7CB4F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE608151 Genomic DNA. Translation: CCE38865.1.
    RefSeqiYP_005309664.1. NC_016934.1.

    Genome annotation databases

    EnsemblBacteriaiCCE38865; CCE38865; UDA_3432c.
    GeneIDi13109779.
    KEGGimtd:UDA_3432c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE608151 Genomic DNA. Translation: CCE38865.1 .
    RefSeqi YP_005309664.1. NC_016934.1.

    3D structure databases

    ProteinModelPortali H6S8M7.
    SMRi H6S8M7. Positions 12-447.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi H6S8M7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCE38865 ; CCE38865 ; UDA_3432c .
    GeneIDi 13109779.
    KEGGi mtd:UDA_3432c.

    Phylogenomic databases

    KOi K01580.
    OMAi PTFQINF.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome shotgun sequencing of one Colombian clinical isolate of Mycobacterium tuberculosis reveals DosR regulon gene deletions."
      Isaza J.P., Duque C., Gomez V., Robledo J., Barrera L.F., Alzate J.F.
      FEMS Microbiol. Lett. 330:113-120(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UT205Imported.

    Entry informationi

    Entry nameiH6S8M7_MYCTX
    AccessioniPrimary (citable) accession number: H6S8M7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2012
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3