Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

H6S8F3

- H6S8F3_MYCTX

UniProt

H6S8F3 - H6S8F3_MYCTX

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd1

Organism
Mycobacterium tuberculosis UT205
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851NADPUniRule annotation
Sitei142 – 1421Critical for catalysisUniRule annotation
Sitei215 – 2151Critical for catalysisUniRule annotation
Metal bindingi255 – 2551Magnesium or manganeseUniRule annotation
Binding sitei263 – 2631NADPUniRule annotation
Metal bindingi278 – 2781Magnesium or manganeseUniRule annotation
Binding sitei331 – 3311NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi78 – 803NADPUniRule annotation
Nucleotide bindingi313 – 3186NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icd1Imported
ORF Names:UDA_3339cImported
OrganismiMycobacterium tuberculosis UT205Imported
Taxonomic identifieri1097669 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000007521: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiH6S8F3.

Structurei

3D structure databases

ProteinModelPortaliH6S8F3.
SMRiH6S8F3. Positions 5-406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 1037Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OMAiKNTIMKV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H6S8F3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNAPKIKVS GPVVELDGDE MTRVIWKLIK DMLILPYLDI RLDYYDLGIE
60 70 80 90 100
HRDATDDQVT IDAAYAIKKH GVGVKCATIT PDEARVEEFN LKKMWLSPNG
110 120 130 140 150
TIRNILGGTI FREPIVISNV PRLVPGWTKP IVIGRHAFGD QYRATNFKVD
160 170 180 190 200
QPGTVTLTFT PADGSAPIVH EMVSIPEDGG VVLGMYNFKE SIRDFARASF
210 220 230 240 250
SYGLNAKWPV YLSTKNTILK AYDGMFKDEF ERVYEEEFKA QFEAAGLTYE
260 270 280 290 300
HRLIDDMVAA CLKWEGGYVW ACKNYDGDVQ SDTVAQGYGS LGLMTSVLMT
310 320 330 340 350
ADGKTVEAEA AHGTVTRHYR QYQAGKPTST NPIASIFAWT RGLQHRGKLD
360 370 380 390 400
GTPEVIDFAH KLESVVIATV ESGKMTKDLA ILIGPEQDWL NSEEFLDAIA

DNLEKELAN
Length:409
Mass (Da):45,514
Last modified:April 18, 2012 - v1
Checksum:iFDBC1989DF42383A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE608151 Genomic DNA. Translation: CCE38791.1.
RefSeqiYP_005309590.1. NC_016934.1.

Genome annotation databases

EnsemblBacteriaiCCE38791; CCE38791; UDA_3339c.
GeneIDi13110559.
KEGGimtd:UDA_3339c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE608151 Genomic DNA. Translation: CCE38791.1 .
RefSeqi YP_005309590.1. NC_016934.1.

3D structure databases

ProteinModelPortali H6S8F3.
SMRi H6S8F3. Positions 5-406.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi H6S8F3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCE38791 ; CCE38791 ; UDA_3339c .
GeneIDi 13110559.
KEGGi mtd:UDA_3339c.

Phylogenomic databases

KOi K00031.
OMAi KNTIMKV.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome shotgun sequencing of one Colombian clinical isolate of Mycobacterium tuberculosis reveals DosR regulon gene deletions."
    Isaza J.P., Duque C., Gomez V., Robledo J., Barrera L.F., Alzate J.F.
    FEMS Microbiol. Lett. 330:113-120(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UT205Imported.

Entry informationi

Entry nameiH6S8F3_MYCTX
AccessioniPrimary (citable) accession number: H6S8F3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: November 26, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3