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H6S8F3

- H6S8F3_MYCTX

UniProt

H6S8F3 - H6S8F3_MYCTX

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd1

Organism
Mycobacterium tuberculosis UT205
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei80 – 801Substrate
    Binding sitei85 – 851NADPUniRule annotation
    Binding sitei112 – 1121Substrate
    Binding sitei135 – 1351Substrate
    Sitei142 – 1421Critical for catalysisUniRule annotation
    Sitei215 – 2151Critical for catalysisUniRule annotation
    Metal bindingi255 – 2551Magnesium or manganeseUniRule annotation
    Binding sitei263 – 2631NADPUniRule annotation
    Metal bindingi278 – 2781Magnesium or manganeseUniRule annotation
    Binding sitei331 – 3311NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi78 – 803NADPUniRule annotation
    Nucleotide bindingi313 – 3186NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icd1Imported
    ORF Names:UDA_3339cImported
    OrganismiMycobacterium tuberculosis UT205Imported
    Taxonomic identifieri1097669 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000007521: Chromosome

    PTM / Processingi

    Proteomic databases

    PRIDEiH6S8F3.

    Structurei

    3D structure databases

    ProteinModelPortaliH6S8F3.
    SMRiH6S8F3. Positions 5-406.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni97 – 1037Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.
    OMAiKNTIMKV.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H6S8F3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNAPKIKVS GPVVELDGDE MTRVIWKLIK DMLILPYLDI RLDYYDLGIE    50
    HRDATDDQVT IDAAYAIKKH GVGVKCATIT PDEARVEEFN LKKMWLSPNG 100
    TIRNILGGTI FREPIVISNV PRLVPGWTKP IVIGRHAFGD QYRATNFKVD 150
    QPGTVTLTFT PADGSAPIVH EMVSIPEDGG VVLGMYNFKE SIRDFARASF 200
    SYGLNAKWPV YLSTKNTILK AYDGMFKDEF ERVYEEEFKA QFEAAGLTYE 250
    HRLIDDMVAA CLKWEGGYVW ACKNYDGDVQ SDTVAQGYGS LGLMTSVLMT 300
    ADGKTVEAEA AHGTVTRHYR QYQAGKPTST NPIASIFAWT RGLQHRGKLD 350
    GTPEVIDFAH KLESVVIATV ESGKMTKDLA ILIGPEQDWL NSEEFLDAIA 400
    DNLEKELAN 409
    Length:409
    Mass (Da):45,514
    Last modified:April 18, 2012 - v1
    Checksum:iFDBC1989DF42383A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE608151 Genomic DNA. Translation: CCE38791.1.
    RefSeqiYP_005309590.1. NC_016934.1.

    Genome annotation databases

    EnsemblBacteriaiCCE38791; CCE38791; UDA_3339c.
    GeneIDi13110559.
    KEGGimtd:UDA_3339c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE608151 Genomic DNA. Translation: CCE38791.1 .
    RefSeqi YP_005309590.1. NC_016934.1.

    3D structure databases

    ProteinModelPortali H6S8F3.
    SMRi H6S8F3. Positions 5-406.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi H6S8F3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCE38791 ; CCE38791 ; UDA_3339c .
    GeneIDi 13110559.
    KEGGi mtd:UDA_3339c.

    Phylogenomic databases

    KOi K00031.
    OMAi KNTIMKV.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome shotgun sequencing of one Colombian clinical isolate of Mycobacterium tuberculosis reveals DosR regulon gene deletions."
      Isaza J.P., Duque C., Gomez V., Robledo J., Barrera L.F., Alzate J.F.
      FEMS Microbiol. Lett. 330:113-120(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UT205Imported.

    Entry informationi

    Entry nameiH6S8F3_MYCTX
    AccessioniPrimary (citable) accession number: H6S8F3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2012
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3