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H6S8F3

- H6S8F3_MYCTX

UniProt

H6S8F3 - H6S8F3_MYCTX

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Protein
Isocitrate dehydrogenase [NADP]
Gene
icd1, UDA_3339c
Organism
Mycobacterium tuberculosis UT205
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801Substrate By similarityUniRule annotation
Binding sitei85 – 851NADP By similarity
Binding sitei112 – 1121Substrate By similarityUniRule annotation
Binding sitei135 – 1351Substrate By similarityUniRule annotation
Sitei142 – 1421Critical for catalysis By similarityUniRule annotation
Sitei215 – 2151Critical for catalysis By similarityUniRule annotation
Metal bindingi255 – 2551Magnesium or manganese By similarityUniRule annotation
Binding sitei263 – 2631NADP By similarity
Metal bindingi278 – 2781Magnesium or manganese By similarityUniRule annotation
Binding sitei331 – 3311NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi78 – 803NADP By similarity
Nucleotide bindingi313 – 3186NADP By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icd1Imported
ORF Names:UDA_3339cImported
OrganismiMycobacterium tuberculosis UT205Imported
Taxonomic identifieri1097669 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000007521: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiH6S8F3.

Structurei

3D structure databases

ProteinModelPortaliH6S8F3.
SMRiH6S8F3. Positions 5-406.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 1037Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.
OMAiKNTIMKV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H6S8F3-1 [UniParc]FASTAAdd to Basket

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MSNAPKIKVS GPVVELDGDE MTRVIWKLIK DMLILPYLDI RLDYYDLGIE    50
HRDATDDQVT IDAAYAIKKH GVGVKCATIT PDEARVEEFN LKKMWLSPNG 100
TIRNILGGTI FREPIVISNV PRLVPGWTKP IVIGRHAFGD QYRATNFKVD 150
QPGTVTLTFT PADGSAPIVH EMVSIPEDGG VVLGMYNFKE SIRDFARASF 200
SYGLNAKWPV YLSTKNTILK AYDGMFKDEF ERVYEEEFKA QFEAAGLTYE 250
HRLIDDMVAA CLKWEGGYVW ACKNYDGDVQ SDTVAQGYGS LGLMTSVLMT 300
ADGKTVEAEA AHGTVTRHYR QYQAGKPTST NPIASIFAWT RGLQHRGKLD 350
GTPEVIDFAH KLESVVIATV ESGKMTKDLA ILIGPEQDWL NSEEFLDAIA 400
DNLEKELAN 409
Length:409
Mass (Da):45,514
Last modified:April 18, 2012 - v1
Checksum:iFDBC1989DF42383A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE608151 Genomic DNA. Translation: CCE38791.1.
RefSeqiYP_005309590.1. NC_016934.1.

Genome annotation databases

EnsemblBacteriaiCCE38791; CCE38791; UDA_3339c.
GeneIDi13110559.
KEGGimtd:UDA_3339c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE608151 Genomic DNA. Translation: CCE38791.1 .
RefSeqi YP_005309590.1. NC_016934.1.

3D structure databases

ProteinModelPortali H6S8F3.
SMRi H6S8F3. Positions 5-406.
ModBasei Search...

Proteomic databases

PRIDEi H6S8F3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCE38791 ; CCE38791 ; UDA_3339c .
GeneIDi 13110559.
KEGGi mtd:UDA_3339c.

Phylogenomic databases

KOi K00031.
OMAi KNTIMKV.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome shotgun sequencing of one Colombian clinical isolate of Mycobacterium tuberculosis reveals DosR regulon gene deletions."
    Isaza J.P., Duque C., Gomez V., Robledo J., Barrera L.F., Alzate J.F.
    FEMS Microbiol. Lett. 330:113-120(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UT205Imported.

Entry informationi

Entry nameiH6S8F3_MYCTX
AccessioniPrimary (citable) accession number: H6S8F3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 3, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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