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H6RW11

- H6RW11_BLASD

UniProt

H6RW11 - H6RW11_BLASD

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Protein

D-alanine--D-alanine ligase

Gene

ddlB

Organism
Blastococcus saxobsidens (strain DD2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Binds 2 magnesium or manganese ions per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi278 – 2781Magnesium or manganese 1UniRule annotation
Metal bindingi291 – 2911Magnesium or manganese 1UniRule annotation
Metal bindingi291 – 2911Magnesium or manganese 2UniRule annotation
Metal bindingi293 – 2931Magnesium or manganese 2UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi151 – 20656ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotation

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSAX1146883:GL9E-4900-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlBImported
Synonyms:ddlUniRule annotation
Ordered Locus Names:BLASA_5068Imported
OrganismiBlastococcus saxobsidens (strain DD2)Imported
Taxonomic identifieri1146883 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeGeodermatophilaceaeBlastococcus
ProteomesiUP000007517: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 324208ATP-graspUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

KOiK01921.
OMAiDYTARYT.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H6RW11-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSETAPAPDT TGGTAPHPLR AVVLAGGLTF EREVSLSSGT QVVEELTRAG
60 70 80 90 100
LDAELRDADA ELLPGLAAAP ADAVFIALHG ATGEDGALRA VLDLAGVPYV
110 120 130 140 150
GSPAAACRLA WDKPAAKSVV RSAAVTTPDW VALPHSTFRE LGAGAVLDLM
160 170 180 190 200
VARLGLPLMV KPASGGSALG VQKVSRVEDL PAAMVSCFAY GDTVMVERFV
210 220 230 240 250
EGVELAIAVV DLGDGPEALP AVEIEPESGV FDYASRYTPG LTEYHAPARI
260 270 280 290 300
PDETAARAAE VAVRVHQVLG LADLSRTDAI VTPDGEVHFL EVNVSPGLTE
310 320 330
TSMFPMAVEA AGHELGDVLA RLLARRASAG R
Length:331
Mass (Da):34,138
Last modified:April 18, 2012 - v1
Checksum:i6BECC89154866A23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO117623 Genomic DNA. Translation: CCG05841.1.
RefSeqiWP_014378700.1. NC_016943.1.
YP_005331867.1. NC_016943.1.

Genome annotation databases

EnsemblBacteriaiCCG05841; CCG05841; BLASA_5068.
GeneIDi11920599.
KEGGibsd:BLASA_5068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO117623 Genomic DNA. Translation: CCG05841.1 .
RefSeqi WP_014378700.1. NC_016943.1.
YP_005331867.1. NC_016943.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCG05841 ; CCG05841 ; BLASA_5068 .
GeneIDi 11920599.
KEGGi bsd:BLASA_5068.

Phylogenomic databases

KOi K01921.
OMAi DYTARYT.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci BSAX1146883:GL9E-4900-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Blastococcus saxobsidens strain DD2."
    Genoscope.
    Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DD2Imported.

Entry informationi

Entry nameiH6RW11_BLASD
AccessioniPrimary (citable) accession number: H6RW11
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: November 26, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3