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H6RW11 (H6RW11_BLASD) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlB EMBL CCG05841.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:BLASA_5068 EMBL CCG05841.1
OrganismBlastococcus saxobsidens (strain DD2) [Complete proteome] [HAMAP] EMBL CCG05841.1
Taxonomic identifier1146883 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeGeodermatophilaceaeBlastococcus

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain117 – 324208ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding151 – 20656ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2781Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2911Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2911Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2931Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
H6RW11 [UniParc].

Last modified April 18, 2012. Version 1.
Checksum: 6BECC89154866A23

FASTA33134,138
        10         20         30         40         50         60 
MSETAPAPDT TGGTAPHPLR AVVLAGGLTF EREVSLSSGT QVVEELTRAG LDAELRDADA 

        70         80         90        100        110        120 
ELLPGLAAAP ADAVFIALHG ATGEDGALRA VLDLAGVPYV GSPAAACRLA WDKPAAKSVV 

       130        140        150        160        170        180 
RSAAVTTPDW VALPHSTFRE LGAGAVLDLM VARLGLPLMV KPASGGSALG VQKVSRVEDL 

       190        200        210        220        230        240 
PAAMVSCFAY GDTVMVERFV EGVELAIAVV DLGDGPEALP AVEIEPESGV FDYASRYTPG 

       250        260        270        280        290        300 
LTEYHAPARI PDETAARAAE VAVRVHQVLG LADLSRTDAI VTPDGEVHFL EVNVSPGLTE 

       310        320        330 
TSMFPMAVEA AGHELGDVLA RLLARRASAG R 

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References

[1]"Complete genome sequence of Blastococcus saxobsidens strain DD2."
Genoscope.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DD2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO117623 Genomic DNA. Translation: CCG05841.1.
RefSeqYP_005331867.1. NC_016943.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCG05841; CCG05841; BLASA_5068.
GeneID11920599.
KEGGbsd:BLASA_5068.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMADYTARYT.

Enzyme and pathway databases

BioCycBSAX1146883:GL9E-4900-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH6RW11_BLASD
AccessionPrimary (citable) accession number: H6RW11
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: June 11, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)