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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Blastococcus saxobsidens (strain DD2)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei13Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei64SubstrateUniRule annotation1
Active sitei91Proton donor/acceptorUniRule annotation1
Binding sitei102SubstrateUniRule annotation1
Sitei186Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
Biological processGluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotationImported
Ordered Locus Names:BLASA_4502Imported
OrganismiBlastococcus saxobsidens (strain DD2)Imported
Taxonomic identifieri1146883 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaGeodermatophilalesGeodermatophilaceaeBlastococcus
Proteomesi
  • UP000007517 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliH6RPP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 19Substrate bindingUniRule annotation8
Regioni25 – 26Substrate bindingUniRule annotation2
Regioni91 – 94Substrate bindingUniRule annotation4
Regioni118 – 119Substrate bindingUniRule annotation2
Regioni187 – 188Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01834
OMAiRMLPYWY
OrthoDBiPOG091H03E2

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 2 hits
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

H6RPP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSPGTLVL LRHGESEWNK ANLFTGWVDV PLTEKGREEA ARGGRLMAEH
60 70 80 90 100
GLLPDVSHTS LLRRAIMTAE LALHEADRQW IPVLRSWRLN ERHYGALQGK
110 120 130 140 150
DKAATLAEYG EEQFMTWRRS YDTPPPPIEP GSEFSQDGDA RYAFLPPEAR
160 170 180 190 200
PATECLADVV VRMLPYWYDA IVPDLRQGRT VLVAAHGNSL RALVKHLDGM
210 220 230 240 250
GEQEVVGLNI PTGIPLRYDL DADLRPVKPG GQYLDPDAAA AAIEAVKNQG

KR
Length:252
Mass (Da):27,981
Last modified:April 18, 2012 - v1
Checksum:iB393C1EACBA01C46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO117623 Genomic DNA Translation: CCG05306.1

Genome annotation databases

EnsemblBacteriaiCCG05306; CCG05306; BLASA_4502
KEGGibsd:BLASA_4502

Similar proteinsi

Entry informationi

Entry nameiH6RPP7_BLASD
AccessioniPrimary (citable) accession number: H6RPP7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: March 28, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health