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H6RLV4 (H6RLV4_BLASD) Unreviewed, UniProtKB/TrEMBL

Last modified October 16, 2013. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Name:icd EMBL CCG05033.1
Ordered Locus Names:BLASA_4208 EMBL CCG05033.1
OrganismBlastococcus saxobsidens (strain DD2) [Complete proteome] [HAMAP] EMBL CCG05033.1
Taxonomic identifier1146883 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeGeodermatophilaceaeBlastococcus

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443 PIRNR PIRNR000108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding309 – 3146NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity

Sites

Metal binding2511Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2741Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity
Binding site1321Substrate By similarity
Binding site2591NADP By similarity PIRSR PIRSR000108-4
Binding site3271NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2111Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
H6RLV4 [UniParc].

Last modified April 18, 2012. Version 1.
Checksum: 9115847B903BB5FA

FASTA40445,175
        10         20         30         40         50         60 
MAKIKVEGTV VELDGDEMTR IIWQFIKDQL ILPYLDVNLE YYDLGIEARD ATDDQITVDS 

        70         80         90        100        110        120 
ANAIKKHGVG VKCATITPDE ARVEEFGLKR MYRSPNGTIR NILGGVIFRE PIIMENVPRL 

       130        140        150        160        170        180 
VPGWTKPIVV GRHAFGDQYR ATDFKFPGEG TLTITFTPKD GSEPIEHEVF QSPGGGVAMA 

       190        200        210        220        230        240 
MYNLDDSIRD FARASMNYGL QREYPVYLST KNTILKAYDG RFKDLFEEVF QAEFKEKFDA 

       250        260        270        280        290        300 
AGITYEHRLI DDMVAASLKW EGGYVWACKN YDGDVQSDTV AQGFGSLGLM TSVLMSPDGR 

       310        320        330        340        350        360 
TVEAEAAHGT VTRHFRQHQQ GKETSTNPIA SIFAWTRGLA HRGKLDNTPE VTRFAETLEK 

       370        380        390        400 
VCIDTVESGQ MTKDLALLIS KDQPWLTTQD FLAAIDTNLQ KAMA 

« Hide

References

[1]"Complete genome sequence of Blastococcus saxobsidens strain DD2."
Genoscope.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DD2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO117623 Genomic DNA. Translation: CCG05033.1.
RefSeqYP_005331059.1. NC_016943.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCG05033; CCG05033; BLASA_4208.
GeneID11919774.
KEGGbsd:BLASA_4208.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00031.
OMAQHQQGKP.

Enzyme and pathway databases

BioCycBSAX1146883:GL9E-4083-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH6RLV4_BLASD
AccessionPrimary (citable) accession number: H6RLV4
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: October 16, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)