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H6RLV4

- H6RLV4_BLASD

UniProt

H6RLV4 - H6RLV4_BLASD

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Blastococcus saxobsidens (strain DD2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei211 – 2111Critical for catalysisUniRule annotation
Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
Binding sitei259 – 2591NADPUniRule annotation
Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation
Binding sitei327 – 3271NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi309 – 3146NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBSAX1146883:GL9E-4083-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:BLASA_4208Imported
OrganismiBlastococcus saxobsidens (strain DD2)Imported
Taxonomic identifieri1146883 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeGeodermatophilaceaeBlastococcus
ProteomesiUP000007517: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OMAiFKDEFQR.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H6RLV4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIKVEGTV VELDGDEMTR IIWQFIKDQL ILPYLDVNLE YYDLGIEARD
60 70 80 90 100
ATDDQITVDS ANAIKKHGVG VKCATITPDE ARVEEFGLKR MYRSPNGTIR
110 120 130 140 150
NILGGVIFRE PIIMENVPRL VPGWTKPIVV GRHAFGDQYR ATDFKFPGEG
160 170 180 190 200
TLTITFTPKD GSEPIEHEVF QSPGGGVAMA MYNLDDSIRD FARASMNYGL
210 220 230 240 250
QREYPVYLST KNTILKAYDG RFKDLFEEVF QAEFKEKFDA AGITYEHRLI
260 270 280 290 300
DDMVAASLKW EGGYVWACKN YDGDVQSDTV AQGFGSLGLM TSVLMSPDGR
310 320 330 340 350
TVEAEAAHGT VTRHFRQHQQ GKETSTNPIA SIFAWTRGLA HRGKLDNTPE
360 370 380 390 400
VTRFAETLEK VCIDTVESGQ MTKDLALLIS KDQPWLTTQD FLAAIDTNLQ

KAMA
Length:404
Mass (Da):45,175
Last modified:April 18, 2012 - v1
Checksum:i9115847B903BB5FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO117623 Genomic DNA. Translation: CCG05033.1.
RefSeqiWP_014377905.1. NC_016943.1.
YP_005331059.1. NC_016943.1.

Genome annotation databases

EnsemblBacteriaiCCG05033; CCG05033; BLASA_4208.
GeneIDi11919774.
KEGGibsd:BLASA_4208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO117623 Genomic DNA. Translation: CCG05033.1 .
RefSeqi WP_014377905.1. NC_016943.1.
YP_005331059.1. NC_016943.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCG05033 ; CCG05033 ; BLASA_4208 .
GeneIDi 11919774.
KEGGi bsd:BLASA_4208.

Phylogenomic databases

KOi K00031.
OMAi FKDEFQR.

Enzyme and pathway databases

BioCyci BSAX1146883:GL9E-4083-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Blastococcus saxobsidens strain DD2."
    Genoscope.
    Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DD2Imported.

Entry informationi

Entry nameiH6RLV4_BLASD
AccessioniPrimary (citable) accession number: H6RLV4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: October 29, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3