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H6RLV4

- H6RLV4_BLASD

UniProt

H6RLV4 - H6RLV4_BLASD

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Blastococcus saxobsidens (strain DD2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei211 – 2111Critical for catalysisUniRule annotation
    Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
    Binding sitei259 – 2591NADPUniRule annotation
    Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation
    Binding sitei327 – 3271NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi309 – 3146NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciBSAX1146883:GL9E-4083-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:BLASA_4208Imported
    OrganismiBlastococcus saxobsidens (strain DD2)Imported
    Taxonomic identifieri1146883 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeGeodermatophilaceaeBlastococcus
    ProteomesiUP000007517: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.
    OMAiFKDEFQR.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H6RLV4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIKVEGTV VELDGDEMTR IIWQFIKDQL ILPYLDVNLE YYDLGIEARD    50
    ATDDQITVDS ANAIKKHGVG VKCATITPDE ARVEEFGLKR MYRSPNGTIR 100
    NILGGVIFRE PIIMENVPRL VPGWTKPIVV GRHAFGDQYR ATDFKFPGEG 150
    TLTITFTPKD GSEPIEHEVF QSPGGGVAMA MYNLDDSIRD FARASMNYGL 200
    QREYPVYLST KNTILKAYDG RFKDLFEEVF QAEFKEKFDA AGITYEHRLI 250
    DDMVAASLKW EGGYVWACKN YDGDVQSDTV AQGFGSLGLM TSVLMSPDGR 300
    TVEAEAAHGT VTRHFRQHQQ GKETSTNPIA SIFAWTRGLA HRGKLDNTPE 350
    VTRFAETLEK VCIDTVESGQ MTKDLALLIS KDQPWLTTQD FLAAIDTNLQ 400
    KAMA 404
    Length:404
    Mass (Da):45,175
    Last modified:April 18, 2012 - v1
    Checksum:i9115847B903BB5FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO117623 Genomic DNA. Translation: CCG05033.1.
    RefSeqiWP_014377905.1. NC_016943.1.
    YP_005331059.1. NC_016943.1.

    Genome annotation databases

    EnsemblBacteriaiCCG05033; CCG05033; BLASA_4208.
    GeneIDi11919774.
    KEGGibsd:BLASA_4208.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO117623 Genomic DNA. Translation: CCG05033.1 .
    RefSeqi WP_014377905.1. NC_016943.1.
    YP_005331059.1. NC_016943.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCG05033 ; CCG05033 ; BLASA_4208 .
    GeneIDi 11919774.
    KEGGi bsd:BLASA_4208.

    Phylogenomic databases

    KOi K00031.
    OMAi FKDEFQR.

    Enzyme and pathway databases

    BioCyci BSAX1146883:GL9E-4083-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Blastococcus saxobsidens strain DD2."
      Genoscope.
      Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DD2Imported.

    Entry informationi

    Entry nameiH6RLV4_BLASD
    AccessioniPrimary (citable) accession number: H6RLV4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2012
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3