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H6RLM3

- H6RLM3_BLASD

UniProt

H6RLM3 - H6RLM3_BLASD

Protein

Probable DNA ligase

Gene

ligB2

Organism
Blastococcus saxobsidens (strain DD2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei210 – 2101ATPUniRule annotation
    Active sitei212 – 2121N6-AMP-lysine intermediateUniRule annotation
    Binding sitei217 – 2171ATPUniRule annotation
    Binding sitei232 – 2321ATPUniRule annotation
    Binding sitei261 – 2611ATPUniRule annotation
    Binding sitei302 – 3021ATPUniRule annotation
    Binding sitei378 – 3781ATPUniRule annotation
    Binding sitei384 – 3841ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBSAX1146883:GL9E-2786-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligB2Imported
    Synonyms:ligUniRule annotation
    Ordered Locus Names:BLASA_2878Imported
    OrganismiBlastococcus saxobsidens (strain DD2)Imported
    Taxonomic identifieri1146883 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeGeodermatophilaceaeBlastococcus
    ProteomesiUP000007517: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK01971.
    OMAiRKVKPVH.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H6RLM3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLAEVVAAS TAVAAARGRK AKAGLIAGAL RLADGDEVPA VTAWLSGEPL    50
    QRRLGIGWRS LAALTGGAAA ESTLTVADVD AAFAELATTS GPGSAARREE 100
    LLRGVLSRAT SEEQRFLVRL ITGELRQGAL EGVVLEAVAT ASGVPAADVR 150
    RAFMLSGSLP DTATAALRGG AEALSAISLQ VGRPVRPMLA GPGSSLDAAL 200
    ADLGPDVTVE FKLDGARVQV HRDGNQVRVW TRTLREVTDG VPELVERVRA 250
    LPCRTAVLDG ETLALDDDGR PRAFQDTMSR FGSAGAGGEM PDAGVLLSPF 300
    FFDLLHLDGR DLLDEPLDIR LDALAGLLAD DASAPLRMPG VRRPRPGQAA 350
    QVLEHALDAG HEGVVVKDLA APYAAGRRGK AWQKVKPVHT LDLVVLGAEW 400
    GYGRRTGTLS NIHLGARDPD GGEPVMVGKT FKGMTDELLA WQTRTFPEHT 450
    REETPWGVLL EPALVVEIAV DGAQRSPRYP GGVALRFARV LRYRPDKTPA 500
    EADTLEAVRA LLAGG 515
    Length:515
    Mass (Da):54,233
    Last modified:April 18, 2012 - v1
    Checksum:i1FBED4B2B38F3F32
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO117623 Genomic DNA. Translation: CCG03749.1.
    RefSeqiWP_014376632.1. NC_016943.1.
    YP_005329780.1. NC_016943.1.

    Genome annotation databases

    EnsemblBacteriaiCCG03749; CCG03749; BLASA_2878.
    GeneIDi11918476.
    KEGGibsd:BLASA_2878.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO117623 Genomic DNA. Translation: CCG03749.1 .
    RefSeqi WP_014376632.1. NC_016943.1.
    YP_005329780.1. NC_016943.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCG03749 ; CCG03749 ; BLASA_2878 .
    GeneIDi 11918476.
    KEGGi bsd:BLASA_2878.

    Phylogenomic databases

    KOi K01971.
    OMAi RKVKPVH.

    Enzyme and pathway databases

    BioCyci BSAX1146883:GL9E-2786-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Blastococcus saxobsidens strain DD2."
      Genoscope.
      Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DD2Imported.

    Entry informationi

    Entry nameiH6RLM3_BLASD
    AccessioniPrimary (citable) accession number: H6RLM3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2012
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3