ID   H6R7X8_NOCCG            Unreviewed;       578 AA.
AC   H6R7X8;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Glycerol-3-phosphate dehydrogenase {ECO:0000313|EMBL:CCF63522.1};
GN   Name=glpD {ECO:0000313|EMBL:CCF63522.1};
GN   OrderedLocusNames=NOCYR_2753 {ECO:0000313|EMBL:CCF63522.1};
OS   Nocardia cyriacigeorgica (strain GUH-2).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=1127134 {ECO:0000313|EMBL:CCF63522.1, ECO:0000313|Proteomes:UP000008190};
RN   [1] {ECO:0000313|EMBL:CCF63522.1, ECO:0000313|Proteomes:UP000008190}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GUH-2 {ECO:0000313|EMBL:CCF63522.1,
RC   ECO:0000313|Proteomes:UP000008190};
RX   PubMed=22461543; DOI=10.1128/JB.00161-12;
RA   Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L.,
RA   Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S.,
RA   Nazaret S., Neto M., Petit S., Roche D., Vallenet D., Rodriguez-Nava V.,
RA   Richard Y., Cournoyer B., Blaha D.;
RT   "Genome sequence of the human- and animal-pathogenic strain Nocardia
RT   cyriacigeorgica GUH-2.";
RL   J. Bacteriol. 194:2098-2099(2012).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the FAD-dependent glycerol-3-phosphate
CC       dehydrogenase family. {ECO:0000256|ARBA:ARBA00007330}.
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DR   EMBL; FO082843; CCF63522.1; -; Genomic_DNA.
DR   RefSeq; WP_014350982.1; NC_016887.1.
DR   AlphaFoldDB; H6R7X8; -.
DR   STRING; 1127134.NOCYR_2753; -.
DR   KEGG; ncy:NOCYR_2753; -.
DR   eggNOG; COG0578; Bacteria.
DR   HOGENOM; CLU_015740_5_1_11; -.
DR   OrthoDB; 9766796at2; -.
DR   Proteomes; UP000008190; Chromosome.
DR   GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
DR   GO; GO:0004368; F:glycerol-3-phosphate dehydrogenase (quinone) activity; IEA:InterPro.
DR   GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.8.870; Alpha-glycerophosphate oxidase, cap domain; 1.
DR   Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR031656; DAO_C.
DR   InterPro; IPR038299; DAO_C_sf.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR000447; G3P_DH_FAD-dep.
DR   PANTHER; PTHR11985; GLYCEROL-3-PHOSPHATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR11985:SF15; GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16901; DAO_C; 1.
DR   PRINTS; PR01001; FADG3PDH.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS00978; FAD_G3PDH_2; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008190}.
FT   DOMAIN          29..381
FT                   /note="FAD dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF01266"
FT   DOMAIN          409..530
FT                   /note="Alpha-glycerophosphate oxidase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16901"
FT   REGION          549..578
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        549..566
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   578 AA;  62330 MW;  E3268B1AEA86A2A3 CRC64;
     MTGHPLAPRP LNPTTRAHAL HTMATTELDV LVIGAGVVGA GTALDAVTRG LRVGLVEARD
     YASGTSSRSS KLIHGGLRYL KQLNFGLVFE ALRERSLILD TLAPHLAKPV EFLYPLERPV
     LDRAWAGAGI GVYDILGAGR GVPAHHRHLG RHATRDRFPG AGARIRGGIS FYEGQIDDAR
     HTMMLARTAA THGALCASST RVIDFLRDGE RITGATVEDL ETGQRFDIRA TRVINAAGPW
     TDEIQAMLDA TPQFRIRTSK GVHIVVPRDC IDATTGLITE TDKSLLFVIP CPWSDQHWVI
     GTTDTPWDHD LAHPAATRTD IDYILDQANR LLDNPIGHDD IVGVYTGLRP LLAGNTDQTT
     TLSREHAVIT PVPGLVLVAG GKYTTYRVMA ADAVDAAIAG LPQRIGPTRT HQVPLVGAHG
     YTELSLARAR LADDLQLPPA TIDHLLGRYG SAITEIRDLI TTDPQLARPL GTTAYLRAEI
     VYAVTHEGAL HLDDILTRRT HLSIETLDRG TAVAAEAAAL AAPHLGWDDT DIAREIECYT
     SRVAAELRAQ HQPDDATADA IRRTAPDSRD TPATPVGA
//