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Protein
Submitted name:

6-phosphofructokinase

Gene

pfkA

Organism
Nocardia cyriacigeorgica (strain GUH-2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.SAAS annotation

Pathway:iglycolysis

This protein is involved in step 3 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.SAAS annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi)
  3. 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciNCYR1127134:GLHX-3964-MONOMER.
UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Submitted name:
6-phosphofructokinaseImported
Gene namesi
Name:pfkAImported
Ordered Locus Names:NOCYR_3974Imported
OrganismiNocardia cyriacigeorgica (strain GUH-2)Imported
Taxonomic identifieri1127134 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeNocardia
ProteomesiUP000008190 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi1127134.NOCYR_3974.

Family & Domainsi

Phylogenomic databases

OMAiCKTAINY.

Family and domain databases

HAMAPiMF_01976. Phosphofructokinase_III.
InterProiIPR022953. ATP_PFK.
IPR012003. ATP_PFK_prok-type.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
IPR012829. Phosphofructokinase_III.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H6R716-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRAVVRTAN GRYGDAIVGF QDGWRGLLED RKIQILNDDR TDRLLNKGGT
60 70 80 90 100
MLGTARTNPD VLREGLGRIQ QTLDDNGIEA LIPIGGEGTL TAASWLSDEG
110 120 130 140 150
VPVVGVPKTI DNDIDCTDVT FGHDTALAIA TEAIDRLHTT AESHQRVMLV
160 170 180 190 200
EVMGRHAGWI AIHAGMAAGA HLTLVPEVPF DVQQVCAMIK RRFQRGDKHF
210 220 230 240 250
ICVVAEGSHP APDSGFTLRE GGVDEFGHER FTGVAQQLGV EIERRIGKEV
260 270 280 290 300
RTTVLGHVQR GGSPTPYDRV LATRFGLHAA EAVHAGHFGQ MVALRGTEIG
310 320
LVPLSEATKQ LKRVPAERYR EAEAFFG
Length:327
Mass (Da):35,517
Last modified:April 18, 2012 - v1
Checksum:iA82B9FC05801D669
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO082843 Genomic DNA. Translation: CCF64735.1.

Genome annotation databases

EnsemblBacteriaiCCF64735; CCF64735; NOCYR_3974.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO082843 Genomic DNA. Translation: CCF64735.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1127134.NOCYR_3974.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCF64735; CCF64735; NOCYR_3974.

Phylogenomic databases

OMAiCKTAINY.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00182.
BioCyciNCYR1127134:GLHX-3964-MONOMER.

Family and domain databases

HAMAPiMF_01976. Phosphofructokinase_III.
InterProiIPR022953. ATP_PFK.
IPR012003. ATP_PFK_prok-type.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
IPR012829. Phosphofructokinase_III.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GUH-2Imported.

Entry informationi

Entry nameiH6R716_NOCCG
AccessioniPrimary (citable) accession number: H6R716
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: July 22, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.