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H6R5Z7 (H6R5Z7_NOCCG) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047
EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL CCF64687.1
Ordered Locus Names:NOCYR_3924 EMBL CCF64687.1
OrganismNocardia cyriacigeorgica (strain GUH-2) [Complete proteome] [HAMAP] EMBL CCF64687.1
Taxonomic identifier1127134 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia ›

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047 SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain140 – 347208ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding168 – 22356ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3021Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3141Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3141Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3161Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
H6R5Z7 [UniParc].

Last modified April 18, 2012. Version 1.
Checksum: 30020A41D7F2193C

FASTA35737,638
        10         20         30         40         50         60 
MVFGGRSNEH AVSCVSAGAV LRNLDPRRYE AVPIGITPNG TWMLGGADVA ALGFGEHSLP 

        70         80         90        100        110        120 
QVDGTGTELL LATDPSRSGD LIPVGDPGAA LGSVDVVFPV LHGPFGEDGT VQGMLELAGI 

       130        140        150        160        170        180 
PYVGPGVLAS AAGMDKEFTK KLLAAEGLPI GTQVVLRARD VTVSEADRER LGLPVFVKPA 

       190        200        210        220        230        240 
RGGSSIGITK VTDWADLDAA IAAARAHDPK VIVEAGIVGR EVECGVLEFP DGRIEASVIA 

       250        260        270        280        290        300 
EIRMPEVDSA APEFYDFETK YLDDVCEFDV PAKLDDAVSD EIRALAVRAF RALDCQGLAR 

       310        320        330        340        350 
VDFFVTADGP VINEINTMPG FTAISMYPRM WDATGIDYRT LVSTLIETAL ARGTGLR

« Hide

References

[1]"Genome sequence of the human- and animal-pathogenic strain Nocardia cyriacigeorgica GUH-2."
Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L., Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S., Nazaret S., Neto M., Petit S., Roche D., Vallenet D., Rodriguez-Nava V., Richard Y., Cournoyer B., Blaha D.
J. Bacteriol. 194:2098-2099(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GUH-2 EMBL CCF64687.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FO082843 Genomic DNA. Translation: CCF64687.1.
RefSeqYP_005265321.1. NC_016887.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCF64687; CCF64687; NOCYR_3924.
GeneID11928807.
KEGGncy:NOCYR_3924.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH6R5Z7_NOCCG
AccessionPrimary (citable) accession number: H6R5Z7
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: April 3, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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