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Protein

Guanylate kinase

Gene

gmk

Organism
Nocardia cyriacigeorgica (strain GUH-2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotationSAAS annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotationSAAS annotation (EC:2.7.4.8UniRule annotationSAAS annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotationImported
Ordered Locus Names:NOCYR_3504Imported
OrganismiNocardia cyriacigeorgica (strain GUH-2)Imported
Taxonomic identifieri1127134 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeNocardia
Proteomesi
  • UP000008190 Componenti: Chromosome

Subcellular locationi

H6R188:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi1127134.NOCYR_3504.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 184Guanylate kinase-likeInterPro annotationAdd BLAST181

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4108UHA. Bacteria.
COG0194. LUCA.
KOiK00942.
OMAiYGTLKSE.
OrthoDBiPOG091H01Q4.

Family and domain databases

HAMAPiMF_00328. Guanylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

H6R188-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKGRLVVLV GPSAVGKSTV VRCVRERLPH LVFSVSATTR APRPGEVDGR
60 70 80 90 100
DYRFVSREEF DAMIEAGELL EWADIHGGLQ RSGTPAAPVR AALSEGLPVL
110 120 130 140 150
VEVDLEGARS VRKAMPEALL VFLAPPSWDE LVSRLRSRGT ESPEVIERRL
160 170 180 190
ETARTELAAC DEFDIVIVND EVTSACEQLV SLFVSTNSSS
Length:190
Mass (Da):20,688
Last modified:April 18, 2012 - v1
Checksum:i8D0FC033A99999E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO082843 Genomic DNA. Translation: CCF64268.1.

Genome annotation databases

EnsemblBacteriaiCCF64268; CCF64268; NOCYR_3504.
KEGGincy:NOCYR_3504.

Similar proteinsi

Entry informationi

Entry nameiH6R188_NOCCG
AccessioniPrimary (citable) accession number: H6R188
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 27, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported