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Protein

Alanine racemase

Gene

alr

Organism
Nocardia cyriacigeorgica (strain GUH-2)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei56Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei154SubstrateUniRule annotation1
Active sitei285Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei333Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciNCYR1127134:G1H8B-953-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:NOCYR_0932Imported
OrganismiNocardia cyriacigeorgica (strain GUH-2)Imported
Taxonomic identifieri1127134 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeNocardia
Proteomesi
  • UP000008190 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi1127134.NOCYR_0932

Structurei

3D structure databases

ProteinModelPortaliH6R0W9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini264 – 393Ala_racemase_CInterPro annotationAdd BLAST130

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit

Sequencei

Sequence statusi: Complete.

H6R0W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHAQGGRSP PMTGLVAGSE TVNAQVETVV DLDAIAHNVR ILREHAGDAA
60 70 80 90 100
VMIVVKADGY NHGAVEVGRA ALAAGAAELG VTTISEAVQL REAGITAPIL
110 120 130 140 150
TWLNNSDADY GAGIAADIEI GVSSLTQLRG VEAAARRLGR TATLTLKVDT
160 170 180 190 200
GLNRNGVSVT EYRDVLTALR GLVDEQVVRF RAIFSHLAHA DEPHHPIIDV
210 220 230 240 250
QRDRFVEAIA VAKEYGLEPE ITHLANSAAT LTRPDLAFDM VRPGIAVYGL
260 270 280 290 300
SPVPELGDFG LRPAMTFQAE VSLVKRVAAG EGVSYGHEWI APHDTTVALI
310 320 330 340 350
PAGYADGVWR RLGGRFDVWV RGARRPSIGR VCMDQLVIDL GENLDGVTEG
360 370 380 390
DTAVLFGTGE GGQPHAQEWA DLLETIHYEV VCAPRGRAVR RFRGGPQ
Length:397
Mass (Da):42,338
Last modified:April 18, 2012 - v1
Checksum:iEF1F4C9BE1B0E37D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO082843 Genomic DNA Translation: CCF61743.1
RefSeqiWP_014349211.1, NC_016887.1

Genome annotation databases

EnsemblBacteriaiCCF61743; CCF61743; NOCYR_0932
KEGGincy:NOCYR_0932

Similar proteinsi

Entry informationi

Entry nameiH6R0W9_NOCCG
AccessioniPrimary (citable) accession number: H6R0W9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: February 28, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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