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H6R0W9

- H6R0W9_NOCCG

UniProt

H6R0W9 - H6R0W9_NOCCG

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Protein

Alanine racemase

Gene
alr, NOCYR_0932
Organism
Nocardia cyriacigeorgica (strain GUH-2)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei154 – 1541Substrate By similarityUniRule annotation
Active sitei285 – 2851Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei333 – 3331Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciNCYR1127134:GLHX-937-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:NOCYR_0932Imported
OrganismiNocardia cyriacigeorgica (strain GUH-2)Imported
Taxonomic identifieri1127134 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000008190: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliH6R0W9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.
OMAiLWQLEAI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

H6R0W9-1 [UniParc]FASTAAdd to Basket

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MLHAQGGRSP PMTGLVAGSE TVNAQVETVV DLDAIAHNVR ILREHAGDAA    50
VMIVVKADGY NHGAVEVGRA ALAAGAAELG VTTISEAVQL REAGITAPIL 100
TWLNNSDADY GAGIAADIEI GVSSLTQLRG VEAAARRLGR TATLTLKVDT 150
GLNRNGVSVT EYRDVLTALR GLVDEQVVRF RAIFSHLAHA DEPHHPIIDV 200
QRDRFVEAIA VAKEYGLEPE ITHLANSAAT LTRPDLAFDM VRPGIAVYGL 250
SPVPELGDFG LRPAMTFQAE VSLVKRVAAG EGVSYGHEWI APHDTTVALI 300
PAGYADGVWR RLGGRFDVWV RGARRPSIGR VCMDQLVIDL GENLDGVTEG 350
DTAVLFGTGE GGQPHAQEWA DLLETIHYEV VCAPRGRAVR RFRGGPQ 397
Length:397
Mass (Da):42,338
Last modified:April 18, 2012 - v1
Checksum:iEF1F4C9BE1B0E37D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO082843 Genomic DNA. Translation: CCF61743.1.
RefSeqiWP_014349211.1. NC_016887.1.
YP_005262385.1. NC_016887.1.

Genome annotation databases

EnsemblBacteriaiCCF61743; CCF61743; NOCYR_0932.
GeneIDi11925830.
KEGGincy:NOCYR_0932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO082843 Genomic DNA. Translation: CCF61743.1 .
RefSeqi WP_014349211.1. NC_016887.1.
YP_005262385.1. NC_016887.1.

3D structure databases

ProteinModelPortali H6R0W9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCF61743 ; CCF61743 ; NOCYR_0932 .
GeneIDi 11925830.
KEGGi ncy:NOCYR_0932.

Phylogenomic databases

KOi K01775.
OMAi LWQLEAI.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci NCYR1127134:GLHX-937-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GUH-2Imported.

Entry informationi

Entry nameiH6R0W9_NOCCG
AccessioniPrimary (citable) accession number: H6R0W9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 3, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi