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H6R0W9

- H6R0W9_NOCCG

UniProt

H6R0W9 - H6R0W9_NOCCG

Protein

Alanine racemase

Gene

alr

Organism
Nocardia cyriacigeorgica (strain GUH-2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei56 – 561Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei154 – 1541SubstrateUniRule annotation
    Active sitei285 – 2851Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei333 – 3331Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciNCYR1127134:GLHX-937-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:NOCYR_0932Imported
    OrganismiNocardia cyriacigeorgica (strain GUH-2)Imported
    Taxonomic identifieri1127134 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
    ProteomesiUP000008190: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei56 – 561N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliH6R0W9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.
    OMAiLWQLEAI.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    H6R0W9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLHAQGGRSP PMTGLVAGSE TVNAQVETVV DLDAIAHNVR ILREHAGDAA    50
    VMIVVKADGY NHGAVEVGRA ALAAGAAELG VTTISEAVQL REAGITAPIL 100
    TWLNNSDADY GAGIAADIEI GVSSLTQLRG VEAAARRLGR TATLTLKVDT 150
    GLNRNGVSVT EYRDVLTALR GLVDEQVVRF RAIFSHLAHA DEPHHPIIDV 200
    QRDRFVEAIA VAKEYGLEPE ITHLANSAAT LTRPDLAFDM VRPGIAVYGL 250
    SPVPELGDFG LRPAMTFQAE VSLVKRVAAG EGVSYGHEWI APHDTTVALI 300
    PAGYADGVWR RLGGRFDVWV RGARRPSIGR VCMDQLVIDL GENLDGVTEG 350
    DTAVLFGTGE GGQPHAQEWA DLLETIHYEV VCAPRGRAVR RFRGGPQ 397
    Length:397
    Mass (Da):42,338
    Last modified:April 18, 2012 - v1
    Checksum:iEF1F4C9BE1B0E37D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO082843 Genomic DNA. Translation: CCF61743.1.
    RefSeqiWP_014349211.1. NC_016887.1.
    YP_005262385.1. NC_016887.1.

    Genome annotation databases

    EnsemblBacteriaiCCF61743; CCF61743; NOCYR_0932.
    GeneIDi11925830.
    KEGGincy:NOCYR_0932.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO082843 Genomic DNA. Translation: CCF61743.1 .
    RefSeqi WP_014349211.1. NC_016887.1.
    YP_005262385.1. NC_016887.1.

    3D structure databases

    ProteinModelPortali H6R0W9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCF61743 ; CCF61743 ; NOCYR_0932 .
    GeneIDi 11925830.
    KEGGi ncy:NOCYR_0932.

    Phylogenomic databases

    KOi K01775.
    OMAi LWQLEAI.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci NCYR1127134:GLHX-937-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GUH-2Imported.

    Entry informationi

    Entry nameiH6R0W9_NOCCG
    AccessioniPrimary (citable) accession number: H6R0W9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2012
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3