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H6R0W9

- H6R0W9_NOCCG

UniProt

H6R0W9 - H6R0W9_NOCCG

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Protein

Alanine racemase

Gene

alr

Organism
Nocardia cyriacigeorgica (strain GUH-2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei154 – 1541SubstrateUniRule annotation
Active sitei285 – 2851Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei333 – 3331Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciNCYR1127134:GLHX-937-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:NOCYR_0932Imported
OrganismiNocardia cyriacigeorgica (strain GUH-2)Imported
Taxonomic identifieri1127134 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000008190: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliH6R0W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiLWQLEAI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

H6R0W9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLHAQGGRSP PMTGLVAGSE TVNAQVETVV DLDAIAHNVR ILREHAGDAA
60 70 80 90 100
VMIVVKADGY NHGAVEVGRA ALAAGAAELG VTTISEAVQL REAGITAPIL
110 120 130 140 150
TWLNNSDADY GAGIAADIEI GVSSLTQLRG VEAAARRLGR TATLTLKVDT
160 170 180 190 200
GLNRNGVSVT EYRDVLTALR GLVDEQVVRF RAIFSHLAHA DEPHHPIIDV
210 220 230 240 250
QRDRFVEAIA VAKEYGLEPE ITHLANSAAT LTRPDLAFDM VRPGIAVYGL
260 270 280 290 300
SPVPELGDFG LRPAMTFQAE VSLVKRVAAG EGVSYGHEWI APHDTTVALI
310 320 330 340 350
PAGYADGVWR RLGGRFDVWV RGARRPSIGR VCMDQLVIDL GENLDGVTEG
360 370 380 390
DTAVLFGTGE GGQPHAQEWA DLLETIHYEV VCAPRGRAVR RFRGGPQ
Length:397
Mass (Da):42,338
Last modified:April 18, 2012 - v1
Checksum:iEF1F4C9BE1B0E37D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO082843 Genomic DNA. Translation: CCF61743.1.
RefSeqiYP_005262385.1. NC_016887.1.

Genome annotation databases

EnsemblBacteriaiCCF61743; CCF61743; NOCYR_0932.
GeneIDi11925830.
KEGGincy:NOCYR_0932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO082843 Genomic DNA. Translation: CCF61743.1 .
RefSeqi YP_005262385.1. NC_016887.1.

3D structure databases

ProteinModelPortali H6R0W9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCF61743 ; CCF61743 ; NOCYR_0932 .
GeneIDi 11925830.
KEGGi ncy:NOCYR_0932.

Phylogenomic databases

KOi K01775.
OMAi LWQLEAI.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci NCYR1127134:GLHX-937-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GUH-2Imported.

Entry informationi

Entry nameiH6R0W9_NOCCG
AccessioniPrimary (citable) accession number: H6R0W9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: November 26, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3