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H6QYF8 (H6QYF8_NOCCG) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribulose bisphosphate carboxylase large chain HAMAP-Rule MF_01338
Short name=RuBisCO large subunit HAMAP-Rule MF_01338
EC=4.1.1.39 HAMAP-Rule MF_01338
Gene names
Name:cbbL HAMAP-Rule MF_01338 EMBL CCF64008.1
Ordered Locus Names:NOCYR_3243 EMBL CCF64008.1
OrganismNocardia cyriacigeorgica (strain GUH-2) [Complete proteome] [HAMAP] EMBL CCF64008.1
Taxonomic identifier1127134 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia ›

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site By similarity. HAMAP-Rule MF_01338

Catalytic activity

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O. HAMAP-Rule MF_01338

3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2. HAMAP-Rule MF_01338

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_01338

Subunit structure

Heterohexadecamer of 8 large chains and 8 small chains By similarity. HAMAP-Rule MF_01338

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel" By similarity. HAMAP-Rule MF_01338

Sequence similarities

Belongs to the RuBisCO large chain family. Type I subfamily. HAMAP-Rule MF_01338

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1731Proton acceptor By similarity HAMAP-Rule MF_01338
Active site2911Proton acceptor By similarity HAMAP-Rule MF_01338
Metal binding1991Magnesium; via carbamate group By similarity HAMAP-Rule MF_01338
Metal binding2011Magnesium By similarity HAMAP-Rule MF_01338
Metal binding2021Magnesium By similarity HAMAP-Rule MF_01338
Binding site1211Substrate; in homodimeric partner By similarity HAMAP-Rule MF_01338
Binding site1711Substrate By similarity HAMAP-Rule MF_01338
Binding site1751Substrate By similarity HAMAP-Rule MF_01338
Binding site2921Substrate By similarity HAMAP-Rule MF_01338
Binding site3241Substrate By similarity HAMAP-Rule MF_01338
Binding site3761Substrate By similarity HAMAP-Rule MF_01338
Site3311Transition state stabilizer By similarity HAMAP-Rule MF_01338

Amino acid modifications

Modified residue1991N6-carboxylysine By similarity HAMAP-Rule MF_01338

Sequences

Sequence LengthMass (Da)Tools
H6QYF8 [UniParc].

Last modified April 18, 2012. Version 1.
Checksum: 7E0BB1F29C3D6323

FASTA48052,784
        10         20         30         40         50         60 
MAEETVRDRW DPGVQSYASM GYYAPDYQPS DTDVLAVFRV TPQPGVDPIE AAAAVAGESS 

        70         80         90        100        110        120 
TATWTVVWTD RLTAHSKYQA KCYRIDEVPG RPGEYFAYVA YDLDLFEEGS ITNLTSSVIG 

       130        140        150        160        170        180 
NVFGFKPLLA LRLEDMRIPV AYVKTFQGPP HGTVMEREYL NKYGRALLGA TVKPKLGLSA 

       190        200        210        220        230        240 
RNYGRVVYEA CKGGLDFTKD DENINSQPFM RWRDRYLFAM EGVNRAMAET GEIKGHYLNV 

       250        260        270        280        290        300 
TAATMEQMYE RAEFAKELGS VVIMMDLTVG YTAMQSMSHW ARRNGVLLHL HRAGHSTFTR 

       310        320        330        340        350        360 
QKTHGVSFRV LAKWCRLIGV DHLHAGTVVG KLEGDPATTK GFYDTLRENV IATEPANGIF 

       370        380        390        400        410        420 
FDQHWASLPG VMPVASGGIH AGQMHQLVEL FGDDVILQFG GGTIGHPLGI AAGAEANRVA 

       430        440        450        460        470        480 
LEAIVQARNE GRDLLREGPE VLRKAAAVNR PLDVALATWG EVSFDYTSTD APDAVPTATH

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References

[1]"Genome sequence of the human- and animal-pathogenic strain Nocardia cyriacigeorgica GUH-2."
Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L., Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S., Nazaret S., Neto M., Petit S., Roche D., Vallenet D., Rodriguez-Nava V., Richard Y., Cournoyer B., Blaha D.
J. Bacteriol. 194:2098-2099(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GUH-2 EMBL CCF64008.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FO082843 Genomic DNA. Translation: CCF64008.1.
RefSeqYP_005264644.1. NC_016887.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCF64008; CCF64008; NOCYR_3243.
GeneID11928122.
KEGGncy:NOCYR_3243.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01601.

Family and domain databases

Gene3D3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPMF_01338. RuBisCO_L_type1.
InterProIPR020878. RuBisCo_large_chain_AS.
IPR020888. RuBisCO_lsu.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMSSF51649. RuBisCO_large. 1 hit.
SSF54966. RuBisCO_large. 1 hit.
PROSITEPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH6QYF8_NOCCG
AccessionPrimary (citable) accession number: H6QYF8
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: May 1, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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