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H6QM93

- H6QM93_9INFA

UniProt

H6QM93 - H6QM93_9INFA

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Protein

Hemagglutinin

Gene

HA

Organism
Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.UniRule annotationSAAS annotation

GO - Biological processi

  1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. fusion of virus membrane with host plasma membrane Source: InterPro
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HemagglutininUniRule annotationSAAS annotation

Keywords - Biological processi

Clathrin- and caveolin-independent endocytosis of virus by hostSAAS annotation, Clathrin-mediated endocytosis of virus by hostSAAS annotation, Fusion of virus membrane with host endosomal membraneSAAS annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
HemagglutininSAAS annotation
Gene namesi
Name:HAImported
OrganismiInfluenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))Imported
Taxonomic identifieri1129347 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

Subcellular locationi

Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host apical cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 PotentialImportedAdd
BLAST
Chaini19 – 564546 PotentialImportedPRO_5000868406Add
BLAST
Chaini19 – 342324HA1ImportedPRO_5000868407Add
BLAST
Chaini343 – 564222HA2ImportedPRO_5000868408Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Subunit structurei

Homotrimer of disulfide-linked HA1-HA2.UniRule annotationSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4H32X-ray2.70A/C/E/G/I/K19-337[»]
B/D/F/H/J/L349-518[»]
4I78X-ray3.18A/B18-342[»]
C/D343-516[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the influenza viruses hemagglutinin family.UniRule annotation

Keywords - Domaini

SignalImported, Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di2.10.77.10. 1 hit.
3.90.20.10. 1 hit.
3.90.209.20. 1 hit.
InterProiIPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
IPR013829. Hemagglutn_stalk.
[Graphical view]
PfamiPF00509. Hemagglutinin. 1 hit.
[Graphical view]
PRINTSiPR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMiSSF49818. SSF49818. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

H6QM93-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELIILLILL NPYTFVLGDR ICIGYQANQN NQTVNTLLEQ NVPVTGAQEI
60 70 80 90 100
LETNHNGKLC SLNGVPPLDL QSCTLAGWLL GNPNCDNLLE AEEWSYIKIN
110 120 130 140 150
ENAPDDLCFP GNFENLQDLL LEMSGVQNFT KVKLFNPQSM TGVTTNNVDQ
160 170 180 190 200
TCPFEGKPSF YRNLNWIQGN SGLPFNIEIK NPTSNPLLLL WGIHNTKDAA
210 220 230 240 250
QQRNLYGNDY SYTIFNFGEK SEEFRPDIGQ RDEIKAHQDR IDYYWGSLPA
260 270 280 290 300
QSTLRIESTG NLIAPEYGFY YKRKEGKGGL MKSKLPISDC STKCQTPLGA
310 320 330 340 350
LNSTLPFQNV HQQTIGNCPK YVKATSLMLA TGLRNNPQME GRGLFGAIAG
360 370 380 390 400
FIEGGWQGMI DGWYGYHHEN QEGSGYAADK EATQKAVDAI TNKVNSIIDK
410 420 430 440 450
MNSQFESNIK EFNRLELRIQ HLSDRVDDAL LDIWSYNTEL LVLLENERTL
460 470 480 490 500
DFHDANVKNL FEKVKAQLKD NAIDEGNGCF LLLHKCNNSC MDDIKNGTYK
510 520 530 540 550
YMDYREESHI EKQKIDGVKL TDYSRYYTMT LYSTIASSVV LGSLIIAAFL
560
WGCQKGSIQC KICI
Length:564
Mass (Da):63,584
Last modified:April 18, 2012 - v1
Checksum:iE71DFB048B81F12F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CY103892 Viral cRNA. Translation: AFC35438.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CY103892 Viral cRNA. Translation: AFC35438.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4H32 X-ray 2.70 A/C/E/G/I/K 19-337 [» ]
B/D/F/H/J/L 349-518 [» ]
4I78 X-ray 3.18 A/B 18-342 [» ]
C/D 343-516 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.10.77.10. 1 hit.
3.90.20.10. 1 hit.
3.90.209.20. 1 hit.
InterProi IPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
IPR013829. Hemagglutn_stalk.
[Graphical view ]
Pfami PF00509. Hemagglutinin. 1 hit.
[Graphical view ]
PRINTSi PR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMi SSF49818. SSF49818. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/little yellow-shouldered bat/Guatemala/060/2010Imported.
  2. "Bat-derived influenza hemagglutinin H17 does not bind canonical avian or human receptors and most likely uses a unique entry mechanism."
    Sun X., Shi Y., Lu X., He J., Gao F., Yan J., Qi J., Gao G.F.
    Cell Rep. 3:769-778(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 19-337 AND 349-518, ACTIVE SITE, GLYCOSYLATION AT ASN-31 AND ASN-128.
  3. "Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities."
    Zhu X., Yu W., McBride R., Li Y., Chen L.M., Donis R.O., Tong S., Paulson J.C., Wilson I.A.
    Proc. Natl. Acad. Sci. U.S.A. 110:1458-1463(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.18 ANGSTROMS) OF 18-342 AND 343-516, ACTIVE SITE, GLYCOSYLATION AT ASN-128.

Entry informationi

Entry nameiH6QM93_9INFA
AccessioniPrimary (citable) accession number: H6QM93
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: November 26, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3