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H6QM93

- H6QM93_9INFA

UniProt

H6QM93 - H6QM93_9INFA

Protein
Submitted name:

Hemagglutinin

Gene

HA

Organism
Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.UniRule annotationSAAS annotation

    GO - Biological processi

    1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
    2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    3. fusion of virus membrane with host plasma membrane Source: InterPro
    4. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    HemagglutininUniRule annotationSAAS annotation

    Keywords - Biological processi

    Clathrin- and caveolin-independent endocytosis of virus by hostSAAS annotation, Clathrin-mediated endocytosis of virus by hostSAAS annotation, Fusion of virus membrane with host endosomal membraneSAAS annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    HemagglutininImported
    Gene namesi
    Name:HAImported
    OrganismiInfluenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))Imported
    Taxonomic identifieri1129347 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

    Subcellular locationi

    Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host apical cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membraneSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818 PotentialImportedAdd
    BLAST
    Chaini19 – 564546 PotentialImportedPRO_5000868406Add
    BLAST
    Chaini19 – 342324HA1ImportedPRO_5000868407Add
    BLAST
    Chaini343 – 564222HA2ImportedPRO_5000868408Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi31 – 311N-linked (GlcNAc...)
    Glycosylationi128 – 1281N-linked (GlcNAc...)Imported

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Interactioni

    Subunit structurei

    Homotrimer of disulfide-linked HA1-HA2.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4H32X-ray2.70A/C/E/G/I/K19-337[»]
    B/D/F/H/J/L349-518[»]
    4I78X-ray3.18A/B18-342[»]
    C/D343-516[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the influenza viruses hemagglutinin family.UniRule annotation

    Keywords - Domaini

    SignalImported, Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di2.10.77.10. 1 hit.
    3.90.20.10. 1 hit.
    3.90.209.20. 1 hit.
    InterProiIPR008980. Capsid_hemagglutn.
    IPR013828. Hemagglutn_HA1_a/b_dom.
    IPR013827. Hemagglutn_HA1_b-rbn_dom.
    IPR000149. Hemagglutn_influenz_A.
    IPR001364. Hemagglutn_influenz_A/B.
    IPR013829. Hemagglutn_stalk.
    [Graphical view]
    PfamiPF00509. Hemagglutinin. 1 hit.
    [Graphical view]
    PRINTSiPR00330. HEMAGGLUTN1.
    PR00329. HEMAGGLUTN12.
    SUPFAMiSSF49818. SSF49818. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    H6QM93-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELIILLILL NPYTFVLGDR ICIGYQANQN NQTVNTLLEQ NVPVTGAQEI    50
    LETNHNGKLC SLNGVPPLDL QSCTLAGWLL GNPNCDNLLE AEEWSYIKIN 100
    ENAPDDLCFP GNFENLQDLL LEMSGVQNFT KVKLFNPQSM TGVTTNNVDQ 150
    TCPFEGKPSF YRNLNWIQGN SGLPFNIEIK NPTSNPLLLL WGIHNTKDAA 200
    QQRNLYGNDY SYTIFNFGEK SEEFRPDIGQ RDEIKAHQDR IDYYWGSLPA 250
    QSTLRIESTG NLIAPEYGFY YKRKEGKGGL MKSKLPISDC STKCQTPLGA 300
    LNSTLPFQNV HQQTIGNCPK YVKATSLMLA TGLRNNPQME GRGLFGAIAG 350
    FIEGGWQGMI DGWYGYHHEN QEGSGYAADK EATQKAVDAI TNKVNSIIDK 400
    MNSQFESNIK EFNRLELRIQ HLSDRVDDAL LDIWSYNTEL LVLLENERTL 450
    DFHDANVKNL FEKVKAQLKD NAIDEGNGCF LLLHKCNNSC MDDIKNGTYK 500
    YMDYREESHI EKQKIDGVKL TDYSRYYTMT LYSTIASSVV LGSLIIAAFL 550
    WGCQKGSIQC KICI 564
    Length:564
    Mass (Da):63,584
    Last modified:April 18, 2012 - v1
    Checksum:iE71DFB048B81F12F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CY103892 Viral cRNA. Translation: AFC35438.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CY103892 Viral cRNA. Translation: AFC35438.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4H32 X-ray 2.70 A/C/E/G/I/K 19-337 [» ]
    B/D/F/H/J/L 349-518 [» ]
    4I78 X-ray 3.18 A/B 18-342 [» ]
    C/D 343-516 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.10.77.10. 1 hit.
    3.90.20.10. 1 hit.
    3.90.209.20. 1 hit.
    InterProi IPR008980. Capsid_hemagglutn.
    IPR013828. Hemagglutn_HA1_a/b_dom.
    IPR013827. Hemagglutn_HA1_b-rbn_dom.
    IPR000149. Hemagglutn_influenz_A.
    IPR001364. Hemagglutn_influenz_A/B.
    IPR013829. Hemagglutn_stalk.
    [Graphical view ]
    Pfami PF00509. Hemagglutinin. 1 hit.
    [Graphical view ]
    PRINTSi PR00330. HEMAGGLUTN1.
    PR00329. HEMAGGLUTN12.
    SUPFAMi SSF49818. SSF49818. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: A/little yellow-shouldered bat/Guatemala/060/2010Imported.
    2. "Bat-derived influenza hemagglutinin H17 does not bind canonical avian or human receptors and most likely uses a unique entry mechanism."
      Sun X., Shi Y., Lu X., He J., Gao F., Yan J., Qi J., Gao G.F.
      Cell Rep. 3:769-778(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 19-337 AND 349-518, GLYCOSYLATION AT ASN-31 AND ASN-128.
    3. "Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities."
      Zhu X., Yu W., McBride R., Li Y., Chen L.M., Donis R.O., Tong S., Paulson J.C., Wilson I.A.
      Proc. Natl. Acad. Sci. U.S.A. 110:1458-1463(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.18 ANGSTROMS) OF 18-342 AND 343-516, GLYCOSYLATION AT ASN-128.

    Entry informationi

    Entry nameiH6QM93_9INFA
    AccessioniPrimary (citable) accession number: H6QM93
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2012
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3