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H6QD97

- H6QD97_PYROT

UniProt

H6QD97 - H6QD97_PYROT

Protein

DNA ligase

Gene

lig

Organism
Pyrobaculum oguniense (strain DSM 13380 / JCM 10595 / TE7)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 1 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei249 – 2491ATPUniRule annotation
    Active sitei251 – 2511N6-AMP-lysine intermediateUniRule annotation
    Binding sitei256 – 2561ATPUniRule annotation
    Binding sitei271 – 2711ATPUniRule annotation
    Binding sitei301 – 3011ATPUniRule annotation
    Binding sitei341 – 3411ATPUniRule annotation
    Binding sitei416 – 4161ATPUniRule annotation
    Binding sitei422 – 4221ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPOGU698757:GHQD-2563-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Pogu_2413Imported
    OrganismiPyrobaculum oguniense (strain DSM 13380 / JCM 10595 / TE7)Imported
    Taxonomic identifieri698757 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
    ProteomesiUP000009062: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiLDPSGYN.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H6QD97-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQFGELVKAL AAVESTTQRS VMVKLLASLF KKALPEEIDK VIYLILGDLR    50
    PPWEGLELGV GEKLCLRALA KATGTSQAEL ESLYKKTGDI GEAARRSLAS 100
    SKRPGLLTFG SQKPLEVSEV YDTLLKVARA SGEGAQDMKI ALLSSLFARS 150
    SPEEGKYIAR FVVGKLRLGV ADMTIIEALA DAYGVRKEDL ERAYHVYPDL 200
    GHLAKLVASG KPLDEVKVTP GVPVLPMLAQ RLSSSSEILA KLGGTAICEY 250
    KYDGERAQIH ISQSGVRIFS RRLEDITHAY PDVVKAVKEA VMAREAILEG 300
    EIVAVDPDTG EMLPFQELMH RKRKHEVVAA MEMYPTVLYL FDVIFVDGED 350
    LTNEPLIYRR VKLSEIVQES DKVQIAKWLM LDDPDSVDVF FHEAVSVGTE 400
    GLICKSPTSE YEMGARGWNW IKYKRDYKSE MIDTVDLVVV GAFYGRGKRA 450
    GLYGAFLLAA YDPSSDMFYT VCKVGSGFTD ADLKKMYEIL QPLKIPHRHP 500
    RVSSKMEADV WFVPQVVIEV IGAEITLSPL HTCCLGAVRP GVGLAVRFPR 550
    FTGRYRTDKG PEQATTVAEM LELYKRQKKV AQPE 584
    Length:584
    Mass (Da):64,776
    Last modified:April 18, 2012 - v1
    Checksum:iE5066712F05608AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003316 Genomic DNA. Translation: AFA40440.1.
    RefSeqiYP_005261047.1. NC_016885.1.

    Genome annotation databases

    EnsemblBacteriaiAFA40440; AFA40440; Pogu_2413.
    GeneIDi11856308.
    KEGGipog:Pogu_2413.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003316 Genomic DNA. Translation: AFA40440.1 .
    RefSeqi YP_005261047.1. NC_016885.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFA40440 ; AFA40440 ; Pogu_2413 .
    GeneIDi 11856308.
    KEGGi pog:Pogu_2413.

    Phylogenomic databases

    KOi K10747.
    OMAi LDPSGYN.

    Enzyme and pathway databases

    BioCyci POGU698757:GHQD-2563-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Pyrobaculum oguniense."
      Bernick D.L., Karplus K., Lui L.M., Coker J.K.C., Murphy J.N., Cozen A.E., Chan P.P., Lowe T.M.
      Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13380 / JCM 10595 / TE7Imported.

    Entry informationi

    Entry nameiH6QD97_PYROT
    AccessioniPrimary (citable) accession number: H6QD97
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2012
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3