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H6QD97

- H6QD97_PYROT

UniProt

H6QD97 - H6QD97_PYROT

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Protein

DNA ligase

Gene

lig

Organism
Pyrobaculum oguniense (strain DSM 13380 / JCM 10595 / TE7)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei249 – 2491ATPUniRule annotation
Active sitei251 – 2511N6-AMP-lysine intermediateUniRule annotation
Binding sitei256 – 2561ATPUniRule annotation
Binding sitei271 – 2711ATPUniRule annotation
Binding sitei301 – 3011ATPUniRule annotation
Binding sitei341 – 3411ATPUniRule annotation
Binding sitei416 – 4161ATPUniRule annotation
Binding sitei422 – 4221ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPOGU698757:GHQD-2563-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Pogu_2413Imported
OrganismiPyrobaculum oguniense (strain DSM 13380 / JCM 10595 / TE7)Imported
Taxonomic identifieri698757 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000009062: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiLDPSGYN.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H6QD97-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQFGELVKAL AAVESTTQRS VMVKLLASLF KKALPEEIDK VIYLILGDLR
60 70 80 90 100
PPWEGLELGV GEKLCLRALA KATGTSQAEL ESLYKKTGDI GEAARRSLAS
110 120 130 140 150
SKRPGLLTFG SQKPLEVSEV YDTLLKVARA SGEGAQDMKI ALLSSLFARS
160 170 180 190 200
SPEEGKYIAR FVVGKLRLGV ADMTIIEALA DAYGVRKEDL ERAYHVYPDL
210 220 230 240 250
GHLAKLVASG KPLDEVKVTP GVPVLPMLAQ RLSSSSEILA KLGGTAICEY
260 270 280 290 300
KYDGERAQIH ISQSGVRIFS RRLEDITHAY PDVVKAVKEA VMAREAILEG
310 320 330 340 350
EIVAVDPDTG EMLPFQELMH RKRKHEVVAA MEMYPTVLYL FDVIFVDGED
360 370 380 390 400
LTNEPLIYRR VKLSEIVQES DKVQIAKWLM LDDPDSVDVF FHEAVSVGTE
410 420 430 440 450
GLICKSPTSE YEMGARGWNW IKYKRDYKSE MIDTVDLVVV GAFYGRGKRA
460 470 480 490 500
GLYGAFLLAA YDPSSDMFYT VCKVGSGFTD ADLKKMYEIL QPLKIPHRHP
510 520 530 540 550
RVSSKMEADV WFVPQVVIEV IGAEITLSPL HTCCLGAVRP GVGLAVRFPR
560 570 580
FTGRYRTDKG PEQATTVAEM LELYKRQKKV AQPE
Length:584
Mass (Da):64,776
Last modified:April 18, 2012 - v1
Checksum:iE5066712F05608AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003316 Genomic DNA. Translation: AFA40440.1.
RefSeqiYP_005261047.1. NC_016885.1.

Genome annotation databases

EnsemblBacteriaiAFA40440; AFA40440; Pogu_2413.
GeneIDi11856308.
KEGGipog:Pogu_2413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003316 Genomic DNA. Translation: AFA40440.1 .
RefSeqi YP_005261047.1. NC_016885.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFA40440 ; AFA40440 ; Pogu_2413 .
GeneIDi 11856308.
KEGGi pog:Pogu_2413.

Phylogenomic databases

KOi K10747.
OMAi LDPSGYN.

Enzyme and pathway databases

BioCyci POGU698757:GHQD-2563-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Pyrobaculum oguniense."
    Bernick D.L., Karplus K., Lui L.M., Coker J.K.C., Murphy J.N., Cozen A.E., Chan P.P., Lowe T.M.
    Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13380 / JCM 10595 / TE7Imported.

Entry informationi

Entry nameiH6QD97_PYROT
AccessioniPrimary (citable) accession number: H6QD97
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: October 29, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3