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H6QD97

- H6QD97_PYROT

UniProt

H6QD97 - H6QD97_PYROT

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Protein
DNA ligase
Gene
lig, Pogu_2413
Organism
Pyrobaculum oguniense (strain DSM 13380 / JCM 10595 / TE7)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei249 – 2491ATP By similarityUniRule annotation
Active sitei251 – 2511N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei256 – 2561ATP By similarityUniRule annotation
Binding sitei271 – 2711ATP By similarityUniRule annotation
Binding sitei301 – 3011ATP By similarityUniRule annotation
Binding sitei341 – 3411ATP By similarityUniRule annotation
Binding sitei416 – 4161ATP By similarityUniRule annotation
Binding sitei422 – 4221ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPOGU698757:GHQD-2563-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Pogu_2413Imported
OrganismiPyrobaculum oguniense (strain DSM 13380 / JCM 10595 / TE7)Imported
Taxonomic identifieri698757 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000009062: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiLDPSGYN.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H6QD97-1 [UniParc]FASTAAdd to Basket

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MQFGELVKAL AAVESTTQRS VMVKLLASLF KKALPEEIDK VIYLILGDLR    50
PPWEGLELGV GEKLCLRALA KATGTSQAEL ESLYKKTGDI GEAARRSLAS 100
SKRPGLLTFG SQKPLEVSEV YDTLLKVARA SGEGAQDMKI ALLSSLFARS 150
SPEEGKYIAR FVVGKLRLGV ADMTIIEALA DAYGVRKEDL ERAYHVYPDL 200
GHLAKLVASG KPLDEVKVTP GVPVLPMLAQ RLSSSSEILA KLGGTAICEY 250
KYDGERAQIH ISQSGVRIFS RRLEDITHAY PDVVKAVKEA VMAREAILEG 300
EIVAVDPDTG EMLPFQELMH RKRKHEVVAA MEMYPTVLYL FDVIFVDGED 350
LTNEPLIYRR VKLSEIVQES DKVQIAKWLM LDDPDSVDVF FHEAVSVGTE 400
GLICKSPTSE YEMGARGWNW IKYKRDYKSE MIDTVDLVVV GAFYGRGKRA 450
GLYGAFLLAA YDPSSDMFYT VCKVGSGFTD ADLKKMYEIL QPLKIPHRHP 500
RVSSKMEADV WFVPQVVIEV IGAEITLSPL HTCCLGAVRP GVGLAVRFPR 550
FTGRYRTDKG PEQATTVAEM LELYKRQKKV AQPE 584
Length:584
Mass (Da):64,776
Last modified:April 18, 2012 - v1
Checksum:iE5066712F05608AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003316 Genomic DNA. Translation: AFA40440.1.
RefSeqiYP_005261047.1. NC_016885.1.

Genome annotation databases

EnsemblBacteriaiAFA40440; AFA40440; Pogu_2413.
GeneIDi11856308.
KEGGipog:Pogu_2413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003316 Genomic DNA. Translation: AFA40440.1 .
RefSeqi YP_005261047.1. NC_016885.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFA40440 ; AFA40440 ; Pogu_2413 .
GeneIDi 11856308.
KEGGi pog:Pogu_2413.

Phylogenomic databases

KOi K10747.
OMAi LDPSGYN.

Enzyme and pathway databases

BioCyci POGU698757:GHQD-2563-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Pyrobaculum oguniense."
    Bernick D.L., Karplus K., Lui L.M., Coker J.K.C., Murphy J.N., Cozen A.E., Chan P.P., Lowe T.M.
    Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13380 / JCM 10595 / TE7.

Entry informationi

Entry nameiH6QD97_PYROT
AccessioniPrimary (citable) accession number: H6QD97
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: June 11, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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