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H6Q866

- H6Q866_PYROT

UniProt

H6Q866 - H6Q866_PYROT

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Protein
Thymidine kinase
Gene
tdk, Pogu_0769
Organism
Pyrobaculum oguniense (strain DSM 13380 / JCM 10595 / TE7)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Proton acceptor By similarityUniRule annotation
Metal bindingi139 – 1391Zinc By similarityUniRule annotation
Metal bindingi142 – 1421Zinc By similarityUniRule annotation
Metal bindingi177 – 1771Zinc By similarityUniRule annotation
Metal bindingi180 – 1801Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 148ATP By similarityUniRule annotation
Nucleotide bindingi83 – 864ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciPOGU698757:GHQD-832-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Pogu_0769Imported
OrganismiPyrobaculum oguniense (strain DSM 13380 / JCM 10595 / TE7)Imported
Taxonomic identifieri698757 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000009062: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.
OMAiDHISEST.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H6Q866-1 [UniParc]FASTAAdd to Basket

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MLVVIVGPMF AGKTTELIRR VERYVIAGKR AIVFKPSIDA RYDSSKVAAH    50
NGLKFGAYVV PPDEVGVETI GKLGLDYDVV AVDEVQFFPP RLADVLNELA 100
DGRVVIAAGL NLDFRGEPFE TTMRAMAFAD KVISLTAVCK VCGRPATRTQ 150
RLINGAPAPK NSPRILVGGG DSYEARCRRH YVRPA 185
Length:185
Mass (Da):20,131
Last modified:April 18, 2012 - v1
Checksum:i74B4588FC8DE2935
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003316 Genomic DNA. Translation: AFA38796.1.
RefSeqiYP_005259403.1. NC_016885.1.

Genome annotation databases

EnsemblBacteriaiAFA38796; AFA38796; Pogu_0769.
GeneIDi11854577.
KEGGipog:Pogu_0769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003316 Genomic DNA. Translation: AFA38796.1 .
RefSeqi YP_005259403.1. NC_016885.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFA38796 ; AFA38796 ; Pogu_0769 .
GeneIDi 11854577.
KEGGi pog:Pogu_0769.

Phylogenomic databases

KOi K00857.
OMAi DHISEST.

Enzyme and pathway databases

BioCyci POGU698757:GHQD-832-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Pyrobaculum oguniense."
    Bernick D.L., Karplus K., Lui L.M., Coker J.K.C., Murphy J.N., Cozen A.E., Chan P.P., Lowe T.M.
    Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13380 / JCM 10595 / TE7.

Entry informationi

Entry nameiH6Q866_PYROT
AccessioniPrimary (citable) accession number: H6Q866
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: June 11, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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