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H6PSW9 (H6PSW9_RICP3) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL AFB25966.1
Ordered Locus Names:RSA_01850 EMBL AFB25966.1
OrganismRickettsia philipii (strain 364D) [Complete proteome] [HAMAP] EMBL AFB25966.1
Taxonomic identifier481009 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain121 – 315195ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding147 – 19953ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2681Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2841Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
H6PSW9 [UniParc].

Last modified April 18, 2012. Version 1.
Checksum: 91CB4745CEE76EB7

FASTA32135,893
        10         20         30         40         50         60 
MHKYQTHWVE HSIVKILSST GKKHIALMAG GMSAEREVSL VSSEGVSKAL IELGYRVTFI 

        70         80         90        100        110        120 
DMGADIAVRL QEIKPDIVFN CLHGTYGEDG CLPGLLNIMR IPYTHSGVLS SALAFDKIHS 

       130        140        150        160        170        180 
RIWFLTNNIN MAESIVVNKS DNIKNDPMKR PYVIKPLTQG SSIGVEVIFA EDDFNFADYD 

       190        200        210        220        230        240 
FPYGDQVIIE QYIKGRELQV AVLNGKALGA LEIKLLKNRF YDYETKYTAG FADHLCPAPL 

       250        260        270        280        290        300 
PANLYEKLLI ESEKIYKTMN CKGPARAEFI LEEQTNKLYA LEINTHPGMM SLSIVPEIAA 

       310        320 
YAGINFTNLI EEIIKTASFE S 

« Hide

References

[1]"Complete genome sequence of Rickettsia philipii strain 364D."
Johnson S.L., Munk A.C., Han S., Bruce D.C., Dasch G.A.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 364D.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003308 Genomic DNA. Translation: AFB25966.1.
RefSeqYP_005300423.1. NC_016930.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFB25966; AFB25966; RSA_01850.
GeneID11895161.
KEGGrph:RSA_01850.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycRPHI481009:GLJC-351-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH6PSW9_RICP3
AccessionPrimary (citable) accession number: H6PSW9
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: February 19, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)