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H6PLK6

- H6PLK6_RICRI

UniProt

H6PLK6 - H6PLK6_RICRI

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Protein

Alanine racemase

Gene
alr, RPL_00735
Organism
Rickettsia rickettsii str. Colombia
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei133 – 1331Substrate By similarityUniRule annotation
Active sitei249 – 2491Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei297 – 2971Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciRRIC1105102:GJU0-138-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
ORF Names:RPL_00735Imported
OrganismiRickettsia rickettsii str. ColombiaImported
Taxonomic identifieri1105102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000007876: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliH6PLK6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H6PLK6-1 [UniParc]FASTAAdd to Basket

« Hide

MSLCTVEINL STIKNNYLLL QDVCKTSLVG AAVKANGYGL GAIQISKALI    50
EENCRHFFVA SSEEGVNLRN ALGLDINILV LNGVFEHDAL ELIEYNLTPV 100
LNNLKQIEIW QKFSNLKNRL LPCYLHFNTG INRLGLSSDE IEQLINDRDL 150
LKGLDLQYII SHLAISEEID NPYNLEQLNR FKAYLQYFPN VKASLANSGG 200
IFLGQDYHFD LARPGAALYG LNPLTKNPVT LKAPIIHLQN LTLDSHIGYN 250
MTFTTKRDSV IATLPLGYAD GFSRNFSNQG EVFINSRSVP IVGRVSMDLI 300
NIDVTDLPPS EIFLGQEAEI IGNYCTPNKI ASIIGTIGYE VLTNLGSRYK 350
RKYIG 355
Length:355
Mass (Da):39,501
Last modified:April 18, 2012 - v1
Checksum:i7DD4604AEBF6030A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003306 Genomic DNA. Translation: AFB23066.1.
RefSeqiYP_005285690.1. NC_016908.1.

Genome annotation databases

EnsemblBacteriaiAFB23066; AFB23066; RPL_00735.
GeneIDi11785510.
KEGGirrc:RPL_00735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003306 Genomic DNA. Translation: AFB23066.1 .
RefSeqi YP_005285690.1. NC_016908.1.

3D structure databases

ProteinModelPortali H6PLK6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFB23066 ; AFB23066 ; RPL_00735 .
GeneIDi 11785510.
KEGGi rrc:RPL_00735.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci RRIC1105102:GJU0-138-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Johnson S.L., Munk A.C., Han S., Bruce D.C., Dasch G.A.
    Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ColombiaImported.

Entry informationi

Entry nameiH6PLK6_RICRI
AccessioniPrimary (citable) accession number: H6PLK6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: July 9, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi