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H6NSR3 (H6NSR3_9BACL) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP-Rule MF_01897
EC=5.99.1.3 HAMAP-Rule MF_01897
Gene names
Name:gyrA HAMAP-Rule MF_01897
ORF Names:PM3016_8 EMBL AFC27003.1
OrganismPaenibacillus mucilaginosus 3016 EMBL AFC27003.1
Taxonomic identifier1116391 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Paenibacillaceae › Paenibacillus ›

Protein attributes

Sequence length835 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1231O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
H6NSR3 [UniParc].

Last modified April 18, 2012. Version 1.
Checksum: 260500E819C8175B

FASTA83593,804
        10         20         30         40         50         60 
MSEEPRSQVK EIDIGSEMRT SFMDYAMSII VSRALPDVRD GLKPVHRRIL FAMSELGMSP 

        70         80         90        100        110        120 
DKPYKKSARI VGEVIGKYHP HGDSAVYETM VRMAQDFSLR YMLVDGHGNF GSIDGDMAAA 

       130        140        150        160        170        180 
MRYTEARLSK IAMELLRDIN KETIDFVPNY DGEEQEPAVL PSRFPNLLVN GLSGIAVGMA 

       190        200        210        220        230        240 
TNIPPHNLTE VINGVQQLIQ NPEVTPLELM QSIKGPDFPT GGYIMGREGI KQAYATGRGS 

       250        260        270        280        290        300 
VIMRAKTLIE ENGNKARIIV YELPYQVNKA RLIEKIAELV REKKIDGITD LRDESDRNGM 

       310        320        330        340        350        360 
RIVIELRRDV NPNVVLNNLY KQTAMQSNFG IIMLALVNGE PKVLNLRDVL FHYLEHQKVV 

       370        380        390        400        410        420 
IRRRTEFELR KAEARAHILE GLRIALDHLD EVIALIRASR TTEEAREGLM TRFGLSFDQA 

       430        440        450        460        470        480 
QAILDMRLQR LTGLERQKIE EEYAELLKKI AEYKAILADE QLVLAIISEE LNEIKEKFGD 

       490        500        510        520        530        540 
ERRSEITIGE ESIEDEDLIP QSDVVITITH TGYIKRLPVT TYRSQRRGGK GIMGMDTKDK 

       550        560        570        580        590        600 
DFVEHLFVTN THHYLLFFTN KGKVYRLKAY EIPDLSRTAR GTPIINLIQI EQGETINAVI 

       610        620        630        640        650        660 
PVESFDSDKY LFFASKKGLV KKTSLDDYSN IRKGGLIAIT LREDDDLIGV RLTDGNQSII 

       670        680        690        700        710        720 
MGTAQGMSIH FPENEVRPMG RSATGVKGIQ LDEEDHVIDM DVVHEDNSVL IVTSKGFGKR 

       730        740        750        760        770        780 
TPVSEYRLQS RGGKGIKTLN VTSKNGPVVG LKVVQEEEDL MIITAFGTVI RTSMSGISLM 

       790        800        810        820        830 
GRNTQGVRLI NIREEDEVST LARVEKSDDP ADDAEGEESE EIQGTSEGFD ETSEE

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References

[1]"Complete Genome Sequence of Paenibacillus mucilaginosus 3016, a Bacterium Functional as Microbial Fertilizer."
Ma M., Wang Z., Li L., Jiang X., Guan D., Cao F., Chen H., Wang X., Shen D., Du B., Li J.
J. Bacteriol. 194:2777-2778(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 3016 EMBL AFC27003.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003235 Genomic DNA. Translation: AFC27003.1.
RefSeqYP_005310152.1. NC_016935.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFC27003; AFC27003; PM3016_8.
GeneID11889190.
KEGGpmq:PM3016_8.

Phylogenomic databases

KOK02469.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameH6NSR3_9BACL
AccessionPrimary (citable) accession number: H6NSR3
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: April 3, 2013
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info