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H6N4D2 (H6N4D2_GORPV) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP-Rule MF_00061
Short name=CMK HAMAP-Rule MF_00061
EC=2.7.1.148 HAMAP-Rule MF_00061
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase HAMAP-Rule MF_00061
Gene names
Name:ispE HAMAP-Rule MF_00061 EMBL AFA72401.1
Ordered Locus Names:GPOL_c13460 EMBL AFA72401.1
OrganismGordonia polyisoprenivorans (strain DSM 44266 / VH2) [Complete proteome] [HAMAP] EMBL AFA72401.1
Taxonomic identifier1112204 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Gordoniaceae › Gordonia ›

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP-Rule MF_00061 SAAS SAAS004424

Catalytic activity

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP-Rule MF_00061 SAAS SAAS004424

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP-Rule MF_00061 SAAS SAAS004424

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily. HAMAP-Rule MF_00061

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding110 – 12011ATP By similarity HAMAP-Rule MF_00061

Sites

Active site201 By similarity HAMAP-Rule MF_00061
Active site1521 By similarity HAMAP-Rule MF_00061

Sequences

Sequence LengthMass (Da)Tools
H6N4D2 [UniParc].

Last modified April 18, 2012. Version 1.
Checksum: DF1576525DA024A2

FASTA31932,610
        10         20         30         40         50         60 
MSPASLSVIS DAVSVRVPAK VNLHLGVGPL RDDGYHDLVT VYQALSLYDD VTVARAAALG 

        70         80         90        100        110        120 
VTLRREGGRG ADAADVPLDD DNLAIKAVRA LGKWADRDPR VAIEIVKRIP VAGGMAGGSA 

       130        140        150        160        170        180 
DAAGALVALA ALWKLDLPRA ELLEIAAGLG SDVPFSVQGG TAMGTGRGEQ LMPMIARGEL 

       190        200        210        220        230        240 
HWVLAFARDG LSTPAVFAEL DSLRADHADA FDVHNPRPDE LVQALTTGEP TQIAPLLHND 

       250        260        270        280        290        300 
LQPAALSLQP GLRRTLRAGV DAGALNGIVS GSGPTCAFLC ADADAAVAVA AELSGAGVAR 

       310 
SVRTASGPVS GATRQVPGQ

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References

[1]"Involvement of two latex-clearing proteins during rubber degradation and insights into the subsequent degradation pathway revealed by the genome sequence of Gordonia polyisoprenivorans strain VH2."
Hiessl S., Schuldes J., Thurmer A., Halbsguth T., Broker D., Angelov A., Liebl W., Daniel R., Steinbuchel A.
Appl. Environ. Microbiol. 78:2874-2887(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 44266 / VH2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003119 Genomic DNA. Translation: AFA72401.1.
RefSeqYP_005281767.1. NC_016906.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFA72401; AFA72401; GPOL_c13460.
GeneID11781356.
KEGGgpo:GPOL_c13460.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00919.

Enzyme and pathway databases

UniPathwayUPA00056; UER00094.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00061. IspE.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERPTHR20861:SF2. PTHR20861:SF2. 1 hit.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF010376. IspE. 1 hit.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00154. ispE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameH6N4D2_GORPV
AccessionPrimary (citable) accession number: H6N4D2
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: April 3, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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