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H6N3M1

- H6N3M1_GORPV

UniProt

H6N3M1 - H6N3M1_GORPV

Protein
Submitted name:

Isocitrate dehydrogenase [NADP] Icd

Gene

icd

Organism
Gordonia polyisoprenivorans (strain DSM 44266 / VH2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471SubstrateUniRule annotation
    Sitei257 – 2571Critical for catalysis
    Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
    Sitei422 – 4221Critical for catalysisUniRule annotation
    Binding sitei550 – 5501SubstrateUniRule annotation
    Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation
    Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciGPOL1112204:GJWY-2459-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase [NADP] IcdImported (EC:1.1.1.42Imported)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:GPOL_c24630Imported
    OrganismiGordonia polyisoprenivorans (strain DSM 44266 / VH2)Imported
    Taxonomic identifieri1112204 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeGordoniaceaeGordonia
    ProteomesiUP000009154: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate bindingUniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    H6N3M1-1 [UniParc]FASTAAdd to Basket

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    MSAEKPTIIY TLTDEAPMLA THAFLPIIRT FADAADINVE TSDISVAARV    50
    LAEFSDYLSD EQKVPDNLAE LGRLTQDPDT NIIKLPNISA SVPQLTAAIK 100
    ELQDKGYKIP DFPGNPKTDE ERAIRDRYTK CLGSAVNPVL REGNSDRRAP 150
    KAVKEYARKH PHSMGEWSMA SRTHVAHMRH GDFYHGEKSM TLDADRDVKM 200
    ELITAAGETI VLKPKVHLDA GDVIDSMFMS KKALIEFYEE QMEDAYKTGV 250
    MFSLHVKATM MRVSHPIVFG HAVRTFYKEA FAKHGELFDE LGVNVNNGLS 300
    DLYSKIESLP ASKKEEIIDD LHACHEHRPE LAMVDSARGI SNFHSPSDVI 350
    VDASMPAMIR AGGKMYGADG RPKDTKAVNP ESTFSRIYQE MINFCKTNGQ 400
    FDPTTMGTVP NVGLMAQKAE EYGSHDKTFE IPTDGVANIT DLATGEVLLS 450
    QDVEEGDIFR MCIVKDAPIR DWVKLAVTRS RESGMPVVFW LDPYRPHENE 500
    LITKVHTYLK DHDTEGLDIQ IMSQVRAIRY TMERLIRGLD TISATGNILR 550
    DYLTDLFPIL ELGTSAKMLS IVPLMAGGGL YETGAGGSAP KHVKQLIEEN 600
    HLRWDSLGEF LALAVSLEDL GRKNDNPKAK VLAKALDAAT GKLLENNKGP 650
    SRSTGELDNR GSQFYLALYW AKALAEQTED ADLAKYFAPL AKTLEENEQT 700
    IVAELNDVQG TAVDIGGYYA PDNDLTDKVM RPSATLNSAL ESVRG 745
    Length:745
    Mass (Da):82,445
    Last modified:April 18, 2012 - v1
    Checksum:i8492FCB219E0DCE2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003119 Genomic DNA. Translation: AFA73492.1.
    RefSeqiWP_006372751.1. NC_016906.1.
    YP_005282858.1. NC_016906.1.

    Genome annotation databases

    EnsemblBacteriaiAFA73492; AFA73492; GPOL_c24630.
    GeneIDi11782471.
    KEGGigpo:GPOL_c24630.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003119 Genomic DNA. Translation: AFA73492.1 .
    RefSeqi WP_006372751.1. NC_016906.1.
    YP_005282858.1. NC_016906.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFA73492 ; AFA73492 ; GPOL_c24630 .
    GeneIDi 11782471.
    KEGGi gpo:GPOL_c24630.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci GPOL1112204:GJWY-2459-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Involvement of two latex-clearing proteins during rubber degradation and insights into the subsequent degradation pathway revealed by the genome sequence of Gordonia polyisoprenivorans strain VH2."
      Hiessl S., Schuldes J., Thurmer A., Halbsguth T., Broker D., Angelov A., Liebl W., Daniel R., Steinbuchel A.
      Appl. Environ. Microbiol. 78:2874-2887(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 44266 / VH2Imported.

    Entry informationi

    Entry nameiH6N3M1_GORPV
    AccessioniPrimary (citable) accession number: H6N3M1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2012
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3