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Protein
Submitted name:

Isocitrate dehydrogenase [NADP] Icd

Gene

icd

Organism
Gordonia polyisoprenivorans (strain DSM 44266 / VH2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei550 – 5501SubstrateUniRule annotation
Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation
Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciGPOL1112204:GJWY-2459-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase [NADP] IcdImported (EC:1.1.1.42Imported)
Gene namesi
Name:icdImported
Ordered Locus Names:GPOL_c24630Imported
OrganismiGordonia polyisoprenivorans (strain DSM 44266 / VH2)Imported
Taxonomic identifieri1112204 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesGordoniaceaeGordonia
ProteomesiUP000009154 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi1112204.GPOL_c24630.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

H6N3M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEKPTIIY TLTDEAPMLA THAFLPIIRT FADAADINVE TSDISVAARV
60 70 80 90 100
LAEFSDYLSD EQKVPDNLAE LGRLTQDPDT NIIKLPNISA SVPQLTAAIK
110 120 130 140 150
ELQDKGYKIP DFPGNPKTDE ERAIRDRYTK CLGSAVNPVL REGNSDRRAP
160 170 180 190 200
KAVKEYARKH PHSMGEWSMA SRTHVAHMRH GDFYHGEKSM TLDADRDVKM
210 220 230 240 250
ELITAAGETI VLKPKVHLDA GDVIDSMFMS KKALIEFYEE QMEDAYKTGV
260 270 280 290 300
MFSLHVKATM MRVSHPIVFG HAVRTFYKEA FAKHGELFDE LGVNVNNGLS
310 320 330 340 350
DLYSKIESLP ASKKEEIIDD LHACHEHRPE LAMVDSARGI SNFHSPSDVI
360 370 380 390 400
VDASMPAMIR AGGKMYGADG RPKDTKAVNP ESTFSRIYQE MINFCKTNGQ
410 420 430 440 450
FDPTTMGTVP NVGLMAQKAE EYGSHDKTFE IPTDGVANIT DLATGEVLLS
460 470 480 490 500
QDVEEGDIFR MCIVKDAPIR DWVKLAVTRS RESGMPVVFW LDPYRPHENE
510 520 530 540 550
LITKVHTYLK DHDTEGLDIQ IMSQVRAIRY TMERLIRGLD TISATGNILR
560 570 580 590 600
DYLTDLFPIL ELGTSAKMLS IVPLMAGGGL YETGAGGSAP KHVKQLIEEN
610 620 630 640 650
HLRWDSLGEF LALAVSLEDL GRKNDNPKAK VLAKALDAAT GKLLENNKGP
660 670 680 690 700
SRSTGELDNR GSQFYLALYW AKALAEQTED ADLAKYFAPL AKTLEENEQT
710 720 730 740
IVAELNDVQG TAVDIGGYYA PDNDLTDKVM RPSATLNSAL ESVRG
Length:745
Mass (Da):82,445
Last modified:April 18, 2012 - v1
Checksum:i8492FCB219E0DCE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003119 Genomic DNA. Translation: AFA73492.1.
RefSeqiWP_006372751.1. NC_016906.1.

Genome annotation databases

EnsemblBacteriaiAFA73492; AFA73492; GPOL_c24630.
KEGGigpo:GPOL_c24630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003119 Genomic DNA. Translation: AFA73492.1.
RefSeqiWP_006372751.1. NC_016906.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1112204.GPOL_c24630.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFA73492; AFA73492; GPOL_c24630.
KEGGigpo:GPOL_c24630.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciGPOL1112204:GJWY-2459-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Involvement of Two Latex-Clearing Proteins during Rubber Degradation and Insights into the Subsequent Degradation Pathway Revealed by the Genome Sequence of Gordonia polyisoprenivorans Strain VH2."
    Hiessl S., Schuldes J., Thurmer A., Halbsguth T., Broker D., Angelov A., Liebl W., Daniel R., Steinbuchel A.
    Appl. Environ. Microbiol. 78:2874-2887(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44266 / VH2Imported.

Entry informationi

Entry nameiH6N3M1_GORPV
AccessioniPrimary (citable) accession number: H6N3M1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: July 22, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.