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H6N3M1

- H6N3M1_GORPV

UniProt

H6N3M1 - H6N3M1_GORPV

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Protein
Submitted name: Isocitrate dehydrogenase [NADP] Icd
Gene
icd, GPOL_c24630
Organism
Gordonia polyisoprenivorans (strain DSM 44266 / VH2)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471Substrate By similarityUniRule annotation
Sitei257 – 2571Critical for catalysis By similarityUniRule annotation
Metal bindingi352 – 3521Magnesium or manganese By similarityUniRule annotation
Sitei422 – 4221Critical for catalysis By similarityUniRule annotation
Binding sitei550 – 5501Substrate By similarityUniRule annotation
Metal bindingi551 – 5511Magnesium or manganese By similarityUniRule annotation
Metal bindingi555 – 5551Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciGPOL1112204:GJWY-2459-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase [NADP] IcdImported (EC:1.1.1.42Imported)
Gene namesi
Name:icdImported
Ordered Locus Names:GPOL_c24630Imported
OrganismiGordonia polyisoprenivorans (strain DSM 44266 / VH2)Imported
Taxonomic identifieri1112204 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeGordoniaceaeGordonia
ProteomesiUP000009154: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate binding By similarityUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

H6N3M1-1 [UniParc]FASTAAdd to Basket

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MSAEKPTIIY TLTDEAPMLA THAFLPIIRT FADAADINVE TSDISVAARV    50
LAEFSDYLSD EQKVPDNLAE LGRLTQDPDT NIIKLPNISA SVPQLTAAIK 100
ELQDKGYKIP DFPGNPKTDE ERAIRDRYTK CLGSAVNPVL REGNSDRRAP 150
KAVKEYARKH PHSMGEWSMA SRTHVAHMRH GDFYHGEKSM TLDADRDVKM 200
ELITAAGETI VLKPKVHLDA GDVIDSMFMS KKALIEFYEE QMEDAYKTGV 250
MFSLHVKATM MRVSHPIVFG HAVRTFYKEA FAKHGELFDE LGVNVNNGLS 300
DLYSKIESLP ASKKEEIIDD LHACHEHRPE LAMVDSARGI SNFHSPSDVI 350
VDASMPAMIR AGGKMYGADG RPKDTKAVNP ESTFSRIYQE MINFCKTNGQ 400
FDPTTMGTVP NVGLMAQKAE EYGSHDKTFE IPTDGVANIT DLATGEVLLS 450
QDVEEGDIFR MCIVKDAPIR DWVKLAVTRS RESGMPVVFW LDPYRPHENE 500
LITKVHTYLK DHDTEGLDIQ IMSQVRAIRY TMERLIRGLD TISATGNILR 550
DYLTDLFPIL ELGTSAKMLS IVPLMAGGGL YETGAGGSAP KHVKQLIEEN 600
HLRWDSLGEF LALAVSLEDL GRKNDNPKAK VLAKALDAAT GKLLENNKGP 650
SRSTGELDNR GSQFYLALYW AKALAEQTED ADLAKYFAPL AKTLEENEQT 700
IVAELNDVQG TAVDIGGYYA PDNDLTDKVM RPSATLNSAL ESVRG 745
Length:745
Mass (Da):82,445
Last modified:April 18, 2012 - v1
Checksum:i8492FCB219E0DCE2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003119 Genomic DNA. Translation: AFA73492.1.
RefSeqiWP_006372751.1. NC_016906.1.
YP_005282858.1. NC_016906.1.

Genome annotation databases

EnsemblBacteriaiAFA73492; AFA73492; GPOL_c24630.
GeneIDi11782471.
KEGGigpo:GPOL_c24630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003119 Genomic DNA. Translation: AFA73492.1 .
RefSeqi WP_006372751.1. NC_016906.1.
YP_005282858.1. NC_016906.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFA73492 ; AFA73492 ; GPOL_c24630 .
GeneIDi 11782471.
KEGGi gpo:GPOL_c24630.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci GPOL1112204:GJWY-2459-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Involvement of Two Latex-Clearing Proteins during Rubber Degradation and Insights into the Subsequent Degradation Pathway Revealed by the Genome Sequence of Gordonia polyisoprenivorans Strain VH2."
    Hiessl S., Schuldes J., Thurmer A., Halbsguth T., Broker D., Angelov A., Liebl W., Daniel R., Steinbuchel A.
    Appl. Environ. Microbiol. 78:2874-2887(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44266 / VH2.

Entry informationi

Entry nameiH6N3M1_GORPV
AccessioniPrimary (citable) accession number: H6N3M1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 3, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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