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Protein

Alanine racemase

Gene

alr

Organism
Corynebacterium pseudotuberculosis 316
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei36 – 361Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Active sitei262 – 2621Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei310 – 3101Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCPSE1074485:GLBT-445-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
ORF Names:Cp316_0429Imported
OrganismiCorynebacterium pseudotuberculosis 316Imported
Taxonomic identifieri1074485 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000008009: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliH6M3Q3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

H6M3Q3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLLEARIDL DAIAHNTRLI KDKAAAQGAQ LMCVVKADGY NHGAVEVATV
60 70 80 90 100
MEENGADQFG VATIGEALAL REGGIESSIL SWIWSPEQDL GAAIAAEIDL
110 120 130 140 150
AAISLEHVKA LVRASESYGK KPVRVTVKVD TGLHRSGVDK QDWRESFCML
160 170 180 190 200
RDAENIQVTG VFSHFSSADE SDSTETEQQE RAFLNAIELG RSLGLELPVN
210 220 230 240 250
HIANSPATLN RPDLYFDMVR PGLALYGHEP IPGESHGLRE AMSWVGRVTV
260 270 280 290 300
VKPIARGEGT SYGLTWRAEQ DGYLCVVPVG YADGLPRSAQ GHLEITIGGR
310 320 330 340 350
RYPQVGRVCM DQIVVALGEN PYGVAQGDEA VILGPTGMTA TELATAMGTI
360 370
NYELVCRPCG RTVRVFEHSD
Length:370
Mass (Da):39,940
Last modified:April 18, 2012 - v1
Checksum:i10992904BE415E8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003077 Genomic DNA. Translation: AFB71753.1.
RefSeqiYP_005303035.1. NC_016932.1.

Genome annotation databases

EnsemblBacteriaiAFB71753; AFB71753; Cp316_0429.
GeneIDi11891788.
KEGGicpg:Cp316_0429.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003077 Genomic DNA. Translation: AFB71753.1.
RefSeqiYP_005303035.1. NC_016932.1.

3D structure databases

ProteinModelPortaliH6M3Q3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFB71753; AFB71753; Cp316_0429.
GeneIDi11891788.
KEGGicpg:Cp316_0429.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciCPSE1074485:GLBT-445-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 316Imported.

Entry informationi

Entry nameiH6M3Q3_CORPS
AccessioniPrimary (citable) accession number: H6M3Q3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: February 4, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.