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H6M2Q3 (H6M2Q3_CORPS) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL AFB72258.1
ORF Names:Cp316_0947 EMBL AFB72258.1
OrganismCorynebacterium pseudotuberculosis 316 [Complete proteome] EMBL AFB72258.1
Taxonomic identifier1074485 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain151 – 356206ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding179 – 23456ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3111Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3231Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3231Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3251Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
H6M2Q3 [UniParc].

Last modified April 18, 2012. Version 1.
Checksum: 684BD99188CD56FB

FASTA36139,120
        10         20         30         40         50         60 
MTQKPSPNSR VRVAVVYGGQ SSEHSVSCVS AGAIMSHLDP QKYEVFPVGI TRDGVWTVGE 

        70         80         90        100        110        120 
SDATKLRTVD RVMPEVEFVR EVKLSVNPRS AGELRYEDGT LYAQADVIFP ALHGRFGEDG 

       130        140        150        160        170        180 
TIQGMFELSG IPYVGTGVLS SACGMDKEYT KKLLAAEGLP VGKEVILRGD ETLTESDKQM 

       190        200        210        220        230        240 
LRSSPAFVKP ARGGSSIGIS RVIEWEDFDA ALTLAREHDT KVIVEAEIKG VEVECGVLER 

       250        260        270        280        290        300 
ADGSLIASVP AQLEDVDEGE EGFYGFDTKY LDNIVTATIP APFDQQTIAL IQSLSLEAFQ 

       310        320        330        340        350        360 
ALNCRGLSRV DFFVTDQGPV LNEVNTMPGF TPISMYPQVF EATGIGYAEL LSHLIDQALA 


Q 

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References

[1]"Genome Sequence of the Corynebacterium pseudotuberculosis Cp316 Strain, Isolated from the Abscess of a Californian Horse."
Ramos R.T., Silva A., Carneiro A.R., Pinto A.C., Soares Sde C., Santos A.R., Almeida S.S., Guimaraes L.C., Aburjaile F.F., Barbosa E.G., Dorella F.A., Rocha F.S., Cerdeira L.T., Barbosa M.S., Tauch A., Edman J., Spier S., Miyoshi A., Schneider M.P., Azevedo V.
J. Bacteriol. 194:6620-6621(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 316 EMBL AFB72258.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003077 Genomic DNA. Translation: AFB72258.1.
RefSeqYP_005303540.1. NC_016932.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFB72258; AFB72258; Cp316_0947.
GeneID11892317.
KEGGcpg:Cp316_0947.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycCPSE1074485:GLBT-974-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH6M2Q3_CORPS
AccessionPrimary (citable) accession number: H6M2Q3
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: June 11, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)