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H6M0H1

- H6M0H1_FRATL

UniProt

H6M0H1 - H6M0H1_FRATL

Protein

Thymidine kinase

Gene

tdk

Organism
Francisella tularensis subsp. tularensis TI0902
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei88 – 881Proton acceptorUniRule annotation
    Metal bindingi145 – 1451ZincUniRule annotation
    Metal bindingi147 – 1471ZincUniRule annotation
    Metal bindingi187 – 1871ZincUniRule annotation
    Metal bindingi190 – 1901ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi87 – 904ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

    Enzyme and pathway databases

    BioCyciFTUL1001534:GLDI-590-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    ORF Names:FTV_0581Imported
    OrganismiFrancisella tularensis subsp. tularensis TI0902Imported
    Taxonomic identifieri1001534 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000008011: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliH6M0H1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    H6M0H1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKLYFRYSA MDAGKTLDLL KVAYNYEDRG RKPLVLTSAI DKRAGLNKVK    50
    SRIGINQDAY SLTDRDNIFE FVENYNSSNK IDCVLIDEIH FFTQEQVWQL 100
    AEIVDELNIP VICYGLRTNY LGQPFETAAL LLAIADTLEE VKTICHCGKK 150
    ASCNMMVQNG KAIKQGNPIV VDDDSLKEID TKYVSVCRKH WKEGVYE 197
    Length:197
    Mass (Da):22,429
    Last modified:April 18, 2012 - v1
    Checksum:i5D38405A53232252
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003049 Genomic DNA. Translation: AFB80297.1.
    RefSeqiYP_005317786.1. NC_016937.1.

    Genome annotation databases

    EnsemblBacteriaiAFB80297; AFB80297; FTV_0581.
    GeneIDi11880729.
    KEGGiftt:FTV_0581.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003049 Genomic DNA. Translation: AFB80297.1 .
    RefSeqi YP_005317786.1. NC_016937.1.

    3D structure databases

    ProteinModelPortali H6M0H1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFB80297 ; AFB80297 ; FTV_0581 .
    GeneIDi 11880729.
    KEGGi ftt:FTV_0581.

    Phylogenomic databases

    KOi K00857.

    Enzyme and pathway databases

    BioCyci FTUL1001534:GLDI-590-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic Comparison between a Virulent Type A1 Strain of Francisella tularensis and Its Attenuated O-Antigen Mutant."
      Modise T., Ryder C., Mane S.P., Bandara A.B., Jensen R.V., Inzana T.J.
      J. Bacteriol. 194:2775-2776(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TI0902Imported.

    Entry informationi

    Entry nameiH6M0H1_FRATL
    AccessioniPrimary (citable) accession number: H6M0H1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2012
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3