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H6LX84

- H6LX84_FRATL

UniProt

H6LX84 - H6LX84_FRATL

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Protein
Submitted name:

Isocitrate dehydrogenase (NADP)

Gene

idh

Organism
Francisella tularensis subsp. tularensis TIGB03
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431SubstrateUniRule annotation
Sitei253 – 2531Critical for catalysisUniRule annotation
Sitei418 – 4181Critical for catalysisUniRule annotation
Binding sitei545 – 5451SubstrateUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciFTUL1001542:GLDJ-1580-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP)Imported (EC:1.1.1.42Imported)
Gene namesi
Name:idhImported
ORF Names:FTU_1541Imported
OrganismiFrancisella tularensis subsp. tularensis TIGB03Imported
Taxonomic identifieri1001542 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000008010: Chromosome

Structurei

3D structure databases

ProteinModelPortaliH6LX84.
SMRiH6LX84. Positions 3-738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1378Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

H6LX84-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHKIFYTFTD EAPALATGSF LPIVESFTKV ADIELETKDI SLSARILANF
60 70 80 90 100
NDYLTAEQKC SDDLAILGEL AKTPDANIIK LPNISASIPQ LTAAIKELQS
110 120 130 140 150
KGYKIPDYPY EPKDDKEQEI KARYAKVLGS AVNPVLREGN SDRRVADAVK
160 170 180 190 200
KYAEKHPHSM GEWTKDSKSH VASMSADDFY ANEKSYIVPK ATKVKIVHID
210 220 230 240 250
TKGTQTVLKD NLALEEKEII DATKISIKAL REFYKNEIAK AKKEGTLLSL
260 270 280 290 300
HLKATMMKVS DPILFGHAVE IFFEDIFKKY AKEFKELGVN PRNGWGDAVE
310 320 330 340 350
KIKQLPQELQ DKINADIEKV FAKQPDIAMV NSNKGITNLN VPSDVIIDAS
360 370 380 390 400
MPAAIRSSGK MWNKDGKLQD MKAMIPDRCY AGVYAATIDF CKENGAFDVA
410 420 430 440 450
TMGDVSNVGL MAKKAEEYGS HDKTFEIQAD GKVEVIDAEG NVIFEHQVEK
460 470 480 490 500
GDIWRACQTK DIAVKDWVKL VVNRAKITQN PAIFWLDSKR AHDRNLIAKV
510 520 530 540 550
NEYLTHHDTT GLDIQILSPV EATKYSLKRM KEGKNTISVT GNVLRDYLTD
560 570 580 590 600
LFPILELGTS AKMLSIVPLL AGGGLFETGA GGSAPKHVEQ LIEENHLRWD
610 620 630 640 650
SLGEFLALGA SLEDLAIKTR DAKIKVLAET LSQANKDFLD NDKSPRRKVG
660 670 680 690 700
ELDTRGSHFY LAYYWVKALA EQTGNAELKA KFEPIYIELK ANKDKIVKEL
710 720 730
NDAQGKKVDV GGYYHMDRVK LDAVMRPSKT FNTILAQI
Length:738
Mass (Da):82,253
Last modified:April 18, 2012 - v1
Checksum:i1978BCCED9AF345E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003048 Genomic DNA. Translation: AFB79547.1.
RefSeqiYP_005306127.1. NC_016933.1.

Genome annotation databases

EnsemblBacteriaiAFB79547; AFB79547; FTU_1541.
GeneIDi11891072.
KEGGiftg:FTU_1541.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003048 Genomic DNA. Translation: AFB79547.1 .
RefSeqi YP_005306127.1. NC_016933.1.

3D structure databases

ProteinModelPortali H6LX84.
SMRi H6LX84. Positions 3-738.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFB79547 ; AFB79547 ; FTU_1541 .
GeneIDi 11891072.
KEGGi ftg:FTU_1541.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci FTUL1001542:GLDJ-1580-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic Comparison between a Virulent Type A1 Strain of Francisella tularensis and Its Attenuated O-Antigen Mutant."
    Modise T., Ryder C., Mane S.P., Bandara A.B., Jensen R.V., Inzana T.J.
    J. Bacteriol. 194:2775-2776(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TIGB03Imported.

Entry informationi

Entry nameiH6LX84_FRATL
AccessioniPrimary (citable) accession number: H6LX84
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: November 26, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3