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H6LX84

- H6LX84_FRATL

UniProt

H6LX84 - H6LX84_FRATL

Protein
Submitted name:

Isocitrate dehydrogenase (NADP)

Gene

idh

Organism
Francisella tularensis subsp. tularensis TIGB03
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei143 – 1431SubstrateUniRule annotation
    Sitei253 – 2531Critical for catalysisUniRule annotation
    Metal bindingi348 – 3481Magnesium or manganese
    Sitei418 – 4181Critical for catalysisUniRule annotation
    Binding sitei545 – 5451SubstrateUniRule annotation
    Metal bindingi546 – 5461Magnesium or manganese
    Metal bindingi550 – 5501Magnesium or manganese

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciFTUL1001542:GLDJ-1580-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase (NADP)Imported (EC:1.1.1.42Imported)
    Gene namesi
    Name:idhImported
    ORF Names:FTU_1541Imported
    OrganismiFrancisella tularensis subsp. tularensis TIGB03Imported
    Taxonomic identifieri1001542 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000008010: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliH6LX84.
    SMRiH6LX84. Positions 3-738.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1378Substrate bindingUniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    H6LX84-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHKIFYTFTD EAPALATGSF LPIVESFTKV ADIELETKDI SLSARILANF    50
    NDYLTAEQKC SDDLAILGEL AKTPDANIIK LPNISASIPQ LTAAIKELQS 100
    KGYKIPDYPY EPKDDKEQEI KARYAKVLGS AVNPVLREGN SDRRVADAVK 150
    KYAEKHPHSM GEWTKDSKSH VASMSADDFY ANEKSYIVPK ATKVKIVHID 200
    TKGTQTVLKD NLALEEKEII DATKISIKAL REFYKNEIAK AKKEGTLLSL 250
    HLKATMMKVS DPILFGHAVE IFFEDIFKKY AKEFKELGVN PRNGWGDAVE 300
    KIKQLPQELQ DKINADIEKV FAKQPDIAMV NSNKGITNLN VPSDVIIDAS 350
    MPAAIRSSGK MWNKDGKLQD MKAMIPDRCY AGVYAATIDF CKENGAFDVA 400
    TMGDVSNVGL MAKKAEEYGS HDKTFEIQAD GKVEVIDAEG NVIFEHQVEK 450
    GDIWRACQTK DIAVKDWVKL VVNRAKITQN PAIFWLDSKR AHDRNLIAKV 500
    NEYLTHHDTT GLDIQILSPV EATKYSLKRM KEGKNTISVT GNVLRDYLTD 550
    LFPILELGTS AKMLSIVPLL AGGGLFETGA GGSAPKHVEQ LIEENHLRWD 600
    SLGEFLALGA SLEDLAIKTR DAKIKVLAET LSQANKDFLD NDKSPRRKVG 650
    ELDTRGSHFY LAYYWVKALA EQTGNAELKA KFEPIYIELK ANKDKIVKEL 700
    NDAQGKKVDV GGYYHMDRVK LDAVMRPSKT FNTILAQI 738
    Length:738
    Mass (Da):82,253
    Last modified:April 18, 2012 - v1
    Checksum:i1978BCCED9AF345E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003048 Genomic DNA. Translation: AFB79547.1.
    RefSeqiYP_005306127.1. NC_016933.1.

    Genome annotation databases

    EnsemblBacteriaiAFB79547; AFB79547; FTU_1541.
    GeneIDi11891072.
    KEGGiftg:FTU_1541.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003048 Genomic DNA. Translation: AFB79547.1 .
    RefSeqi YP_005306127.1. NC_016933.1.

    3D structure databases

    ProteinModelPortali H6LX84.
    SMRi H6LX84. Positions 3-738.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFB79547 ; AFB79547 ; FTU_1541 .
    GeneIDi 11891072.
    KEGGi ftg:FTU_1541.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci FTUL1001542:GLDJ-1580-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic Comparison between a Virulent Type A1 Strain of Francisella tularensis and Its Attenuated O-Antigen Mutant."
      Modise T., Ryder C., Mane S.P., Bandara A.B., Jensen R.V., Inzana T.J.
      J. Bacteriol. 194:2775-2776(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TIGB03Imported.

    Entry informationi

    Entry nameiH6LX84_FRATL
    AccessioniPrimary (citable) accession number: H6LX84
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2012
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3