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H6LX84

- H6LX84_FRATL

UniProt

H6LX84 - H6LX84_FRATL

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Protein
Submitted name: Isocitrate dehydrogenase (NADP)
Gene
idh, FTU_1541
Organism
Francisella tularensis subsp. tularensis TIGB03
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431Substrate By similarityUniRule annotation
Sitei253 – 2531Critical for catalysis By similarityUniRule annotation
Metal bindingi348 – 3481Magnesium or manganese By similarityUniRule annotation
Sitei418 – 4181Critical for catalysis By similarityUniRule annotation
Binding sitei545 – 5451Substrate By similarityUniRule annotation
Metal bindingi546 – 5461Magnesium or manganese By similarityUniRule annotation
Metal bindingi550 – 5501Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciFTUL1001542:GLDJ-1580-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP)Imported (EC:1.1.1.42Imported)
Gene namesi
Name:idhImported
ORF Names:FTU_1541Imported
OrganismiFrancisella tularensis subsp. tularensis TIGB03Imported
Taxonomic identifieri1001542 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000008010: Chromosome

Structurei

3D structure databases

ProteinModelPortaliH6LX84.
SMRiH6LX84. Positions 3-738.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1378Substrate binding By similarityUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

H6LX84-1 [UniParc]FASTAAdd to Basket

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MHKIFYTFTD EAPALATGSF LPIVESFTKV ADIELETKDI SLSARILANF    50
NDYLTAEQKC SDDLAILGEL AKTPDANIIK LPNISASIPQ LTAAIKELQS 100
KGYKIPDYPY EPKDDKEQEI KARYAKVLGS AVNPVLREGN SDRRVADAVK 150
KYAEKHPHSM GEWTKDSKSH VASMSADDFY ANEKSYIVPK ATKVKIVHID 200
TKGTQTVLKD NLALEEKEII DATKISIKAL REFYKNEIAK AKKEGTLLSL 250
HLKATMMKVS DPILFGHAVE IFFEDIFKKY AKEFKELGVN PRNGWGDAVE 300
KIKQLPQELQ DKINADIEKV FAKQPDIAMV NSNKGITNLN VPSDVIIDAS 350
MPAAIRSSGK MWNKDGKLQD MKAMIPDRCY AGVYAATIDF CKENGAFDVA 400
TMGDVSNVGL MAKKAEEYGS HDKTFEIQAD GKVEVIDAEG NVIFEHQVEK 450
GDIWRACQTK DIAVKDWVKL VVNRAKITQN PAIFWLDSKR AHDRNLIAKV 500
NEYLTHHDTT GLDIQILSPV EATKYSLKRM KEGKNTISVT GNVLRDYLTD 550
LFPILELGTS AKMLSIVPLL AGGGLFETGA GGSAPKHVEQ LIEENHLRWD 600
SLGEFLALGA SLEDLAIKTR DAKIKVLAET LSQANKDFLD NDKSPRRKVG 650
ELDTRGSHFY LAYYWVKALA EQTGNAELKA KFEPIYIELK ANKDKIVKEL 700
NDAQGKKVDV GGYYHMDRVK LDAVMRPSKT FNTILAQI 738
Length:738
Mass (Da):82,253
Last modified:April 18, 2012 - v1
Checksum:i1978BCCED9AF345E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003048 Genomic DNA. Translation: AFB79547.1.
RefSeqiYP_005306127.1. NC_016933.1.

Genome annotation databases

EnsemblBacteriaiAFB79547; AFB79547; FTU_1541.
GeneIDi11891072.
KEGGiftg:FTU_1541.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003048 Genomic DNA. Translation: AFB79547.1 .
RefSeqi YP_005306127.1. NC_016933.1.

3D structure databases

ProteinModelPortali H6LX84.
SMRi H6LX84. Positions 3-738.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFB79547 ; AFB79547 ; FTU_1541 .
GeneIDi 11891072.
KEGGi ftg:FTU_1541.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci FTUL1001542:GLDJ-1580-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic Comparison between a Virulent Type A1 Strain of Francisella tularensis and Its Attenuated O-Antigen Mutant."
    Modise T., Ryder C., Mane S.P., Bandara A.B., Jensen R.V., Inzana T.J.
    J. Bacteriol. 194:2775-2776(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TIGB03Imported.

Entry informationi

Entry nameiH6LX84_FRATL
AccessioniPrimary (citable) accession number: H6LX84
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 3, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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