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H6LLU8 (H6LLU8_STAAU) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2 PIRNR PIRNR000447
EC=2.3.1.179 PIRNR PIRNR000447
Gene names
ORF Names:SAVC_04090 EMBL AEZ36981.1
OrganismStaphylococcus aureus subsp. aureus VC40 EMBL AEZ36981.1
Taxonomic identifier1028799 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP By similarity. PIRNR PIRNR000447

Catalytic activity

(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein]. PIRNR PIRNR000447

Pathway

Lipid metabolism; fatty acid biosynthesis. PIRNR PIRNR000447

Sequence similarities

Belongs to the beta-ketoacyl-ACP synthases family. PIRNR PIRNR000447 RuleBase RU003694

Sequences

Sequence LengthMass (Da)Tools
H6LLU8 [UniParc].

Last modified April 18, 2012. Version 1.
Checksum: 2DB06BB5DD48D175

FASTA41443,739
        10         20         30         40         50         60 
MSQNKRVVIT GMGALSPIGN DVKTTWENAL KGVNGIDKIT RIDTEPYSVH LAGELKNFNI 

        70         80         90        100        110        120 
EDHIDKKEAR RMDRFTQYAI VAAREAVKDA QLDINENTAD RIGVWIGSGI GGMETFEIAH 

       130        140        150        160        170        180 
KQLMDKGPRR VSPFFVPMLI PDMATGQVSI DLGAKGPNGA TVTACATGTN SIGEAFKIVQ 

       190        200        210        220        230        240 
RGDADAMITG GTEAPITHMA IAGFSASRAL STNDDIETAC RPFQEGRDGF VMGEGAGILV 

       250        260        270        280        290        300 
IESLESAQAR GANIYAEIVG YGTTGDAYHI TAPAPEGEGG SRAMQAAMDD AGIEPKDVQY 

       310        320        330        340        350        360 
LNAHGTSTPV GDLNEVKAIK NTFGEAAKHL KVSSTKSMTG HLLGATGGIE AIFSALSIKD 

       370        380        390        400        410 
SKVAPTIHAV TPDPECDLDI VPNEAQDLDI TYAMSNSLGF GGHNAVLVFK KFEA

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References

[1]"Genome Sequence of Staphylococcus aureus VC40, a Vancomycin- and Daptomycin-Resistant Strain, To Study the Genetics of Development of Resistance to Currently Applied Last-Resort Antibiotics."
Sass P., Berscheid A., Jansen A., Oedenkoven M., Szekat C., Strittmatter A., Gottschalk G., Bierbaum G.
J. Bacteriol. 194:2107-2108(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: VC40 EMBL AEZ36981.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003033 Genomic DNA. Translation: AEZ36981.1.
RefSeqYP_005290415.1. NC_016912.1.

3D structure databases

ProteinModelPortalH6LLU8.
SMRH6LLU8. Positions 4-414.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEZ36981; AEZ36981; SAVC_04090.
GeneID11868963.
KEGGsuv:SAVC_04090.

Phylogenomic databases

KOK09458.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR017568. 3-oxoacyl-ACP_synth-2.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
PIRSFPIRSF000447. KAS_II. 1 hit.
SUPFAMSSF53901. Thiolase-like. 2 hits.
TIGRFAMsTIGR03150. fabF. 1 hit.
PROSITEPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH6LLU8_STAAU
AccessionPrimary (citable) accession number: H6LLU8
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: April 3, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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