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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Treponema pallidum subsp. pertenue (strain CDC2)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei71SubstrateUniRule annotation1
Metal bindingi222ManganeseUniRule annotation1
Metal bindingi242Manganese; via tele nitrogenUniRule annotation1
Binding sitei264SubstrateUniRule annotation1
Active sitei266UniRule annotation1
Metal bindingi289ManganeseUniRule annotation1
Binding sitei387GTPUniRule annotation1
Binding sitei418GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi265 – 270GTPUniRule annotation6
Nucleotide bindingi514 – 517GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotationSAAS annotation, KinaseImported, Lyase, Transferase
Biological processGluconeogenesisUniRule annotation
LigandGTP-bindingUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PyruvateImported

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Alternative name(s):
GTP-dependent phosphoenolpyruvate carboxykinaseUniRule annotation
Short name:
GTP-PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotationImported
Ordered Locus Names:TPECDC2_0122Imported
OrganismiTreponema pallidum subsp. pertenue (strain CDC2)Imported
Taxonomic identifieri491079 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000008193 Componenti: Chromosome

Subcellular locationi

H6KSV4:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliH6KSV4.
SMRiH6KSV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 234PEPCK_NInterPro annotationAdd BLAST221
Domaini238 – 605PEPCK_CInterPro annotationAdd BLAST368

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni213 – 215Substrate bindingUniRule annotation3
Regioni385 – 387Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

KOiK01596.
OMAiGPTNNWV.
OrthoDBiPOG091H0B4F.

Family and domain databases

CDDicd00819. PEPCK_GTP. 1 hit.
Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP. 1 hit.
InterProiView protein in InterPro
IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR035077. PEP_carboxykinase_GTP_C.
IPR035078. PEP_carboxykinase_GTP_N.
IPR008210. PEP_carboxykinase_N.
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiView protein in Pfam
PF00821. PEPCK_C. 1 hit.
PF17297. PEPCK_N. 1 hit.
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiView protein in PROSITE
PS00505. PEPCK_GTP. 1 hit.

Sequencei

Sequence statusi: Complete.

H6KSV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELHEIAHAR AKAWIEEMVA LCAPDTVYVC DGSKKEYDTI MQKMVDAGLA
60 70 80 90 100
TPLKKRKNCF LFRSQPSDVA RVEARTFIAS KREDDAGPTN HWTDPAELKK
110 120 130 140 150
TMTGLYSQCM KGRTMYVIPF SMGPVGSPIS KNGIEITDSE YVVCNMHIMT
160 170 180 190 200
RVGTRVLEAL GTDGEFVPCL HSVGKPLGPG VTDAGQWPCA DMERKYISHF
210 220 230 240 250
PEERLVWSFG SGYGGNALLG KKCFALRIAS VLARDEGWLA EHMLILKITN
260 270 280 290 300
PAGKTKYIGA AFPSACGKTN LAMMIPTLPG WKVETVGDDI AWMKFGKDGR
310 320 330 340 350
LYAINPEAGF FGVAPGTSDF SNKNAMDSIK ENAIFTNCGL TEDGDVWWEG
360 370 380 390 400
IGYPAKGTII DWHGVSRPAP TRDKSPKGEE IAHPNARFTA PARQCPAIAS
410 420 430 440 450
NWEDPEGVPI DAFLFGGRRP STVPLVHQAR DWNHGVFLGS IIGSEVTAAV
460 470 480 490 500
ISDQVGQIRR DPFAMLPFCG YHMADYFSHW IKLGSQARAE NLPKIFCVNW
510 520 530 540 550
FRKDAEGNFL WPGYGDNSRV LAWIFDRCDG VDNAVETAIG WMPKEGALNT
560 570 580 590 600
EGLNVSTQAV KELLSVDIAG WKKEIKDIRE NHYPKFGARL PQQLRDALEV
610
LEARINGSEG AACTRDMC
Length:618
Mass (Da):68,125
Last modified:April 18, 2012 - v1
Checksum:i4230B8F77DDD4AA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002375 Genomic DNA. Translation: AEZ58310.1.
RefSeqiWP_010881571.1. NC_016848.1.

Genome annotation databases

EnsemblBacteriaiAEZ58310; AEZ58310; TPECDC2_0122.
KEGGitpc:TPECDC2_0122.

Similar proteinsi

Entry informationi

Entry nameiH6KSV4_TREPD
AccessioniPrimary (citable) accession number: H6KSV4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: October 25, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported