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Protein

L-lactate dehydrogenase

Gene

lldD

Organism
Atlantibacter hermannii NBRC 105704
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotationSAAS annotation

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotationSAAS annotation

Cofactori

FMNUniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24SubstrateUniRule annotation1
Binding sitei106FMNUniRule annotation1
Binding sitei127FMNUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Binding sitei155FMNUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Binding sitei251FMNUniRule annotation1
Active sitei275Proton acceptorUniRule annotation1
Binding sitei278SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi306 – 330FMNUniRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandFlavoprotein, FMNUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotationSAAS annotation (EC:1.1.-.-UniRule annotationSAAS annotation)
Gene namesi
Name:lldDUniRule annotationImported
ORF Names:EH105704_04_01190Imported
OrganismiAtlantibacter hermannii NBRC 105704Imported
Taxonomic identifieri1115512 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeAtlantibacter
Proteomesi
  • UP000010297 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell inner membrane SAAS annotation; Peripheral membrane protein SAAS annotation
  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneSAAS annotation, Cell membrane, Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 375FMN_dhInterPro annotationAdd BLAST363

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotationSAAS annotation

Phylogenomic databases

OrthoDBiPOG091H00L7.

Family and domain databases

CDDicd02809. alpha_hydroxyacid_oxid_FMN. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01559. L_lact_dehydr. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. LldD.
PfamiView protein in Pfam
PF01070. FMN_dh. 1 hit.
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiView protein in PROSITE
PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.

Sequencei

Sequence statusi: Complete.

H5V1L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIISAASDYR AAAQRILPPF LFHYIDGGAY AEYTLRRNVE DLAQVALRQR
60 70 80 90 100
VLKNMSDLSL ETTLFKETLS MPVALAPVGL CGMYARRGEV QAAKAADAKG
110 120 130 140 150
IPFTLSTVSV CPIEEVAPKI QRPMWFQLYV LRDRGFMRNA LERAKAAGCS
160 170 180 190 200
TLVFTVDMPT PGARYRDAHS GMSGANAALR RYWQAATHPQ WAWDVGLHGR
210 220 230 240 250
PHDLGNISTY LGKPTGLEDY IGWLANNFDP SISWKDLEWI REFWDGPMVI
260 270 280 290 300
KGILDPEDAK DAVRFGADGI VVSNHGGRQL DGVLSSARAL PAIADAVKGD
310 320 330 340 350
IAILADSGIR SGLDVVRMIA LGADTVLLGR AYLYALATHG QAGVANLLNL
360 370 380 390 400
IEKEMRVAMT LTGAKSIKEI SRESLVPDPE FTSVLASLPA SSASVSKQVD

AA
Length:402
Mass (Da):43,571
Last modified:April 18, 2012 - v1
Checksum:iDB0328995D79F448
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BAFF01000004 Genomic DNA. Translation: GAB51877.1.
RefSeqiWP_002435400.1. NZ_BAFF01000004.1.

Genome annotation databases

EnsemblBacteriaiGAB51877; GAB51877; EH105704_04_01190.

Similar proteinsi

Entry informationi

Entry nameiH5V1L9_ATLHE
AccessioniPrimary (citable) accession number: H5V1L9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 27, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported