H3HSC8 (H3HSC8_STRPU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Uncharacterized protein EnsemblMetazoa SPU_004588tr
Organism	Strongylocentrotus purpuratus (Purple sea urchin) [Reference proteome] EnsemblMetazoa SPU_004588tr
Taxonomic identifier	7668 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Echinodermata › Eleutherozoa › Echinozoa › Echinoidea › Euechinoidea › Echinacea › Echinoida › Strongylocentrotidae › Strongylocentrotus

Protein attributes

Sequence length	3024 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SAAS SAAS001214
Sequence similarities	Contains 1 SET domain. RuleBase RU004538 Contains 1 post-SET domain. RuleBase RU004541 SAAS SAAS001214

Ontologies

Keywords
Cellular component	Nucleus SAAS SAAS003616
Molecular function	Methyltransferase SAAS SAAS001214 RuleBase RU004541 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular_component	chromosome Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	H3HSC8 [UniParc]. Last modified April 18, 2012. Version 1. Checksum: 539535328B454764	FASTA	3,024	340,598
	10 20 30 40 50 60 MEPFRIIPTR RWLRSSRKAQ EVNETGDQLG ILGAKPKAAS PHPDPNILAK EMEEFEKLMQ 70 80 90 100 110 120 LNSTEGAGSD TKDTTQQNEK GEEPKQAVEA DAYVPDQPTT SLEPYEPAQP TTSPVIPSKD 130 140 150 160 170 180 EQTTVSPEAY EPDQPTPVEE VYTPDQQTCV VNDKTAKGPS LQDSAPYEPE QPTDEPMVLQ 190 200 210 220 230 240 DSGVSAKAKT EVSEVEADMP QLQLDSVTCS SDNHGQIEKG GDLATSEDTD ATLAQNVFNN 250 260 270 280 290 300 EGGNKSEQEN LLPEEWLRKK EKKKKHSHGK HKKPLVEWRL GVLRKDYVIK DFKSFPVDEK 310 320 330 340 350 360 LMATTKHKWN DESEVEHLKF LHSGDGSQTD TSEVSGMTSP AVALSDNELE SDQNTSGDIN 370 380 390 400 410 420 SIGRTPENAP EDDGGINSSK DNDIQRVESK CLEGETKKEE SGEVEKVLEE SASHENVKSG 430 440 450 460 470 480 TGLEDTKPKG DTEIDESSTV EKTEDLGAQK DGDTKEVQKG SVDEEETKKK SEQEEDNSSR 490 500 510 520 530 540 MSTRQSSRRA GRDSGENKTD ADHKSDKKDD DSSRRRSRRS ERYRDDSDDE KRKDSDRSRT 550 560 570 580 590 600 ESDRTRMDTR RRSQRRDRYG RDDSDDESRE GRRRGRSDSR ERRGRSGSRE RRRYRDDDDR 610 620 630 640 650 660 YDRYDRGRRQ RRSDRRSMDR TDDRRSREDD RRNERSVSRE RVDRRRKEKD DKDVKKDVDQ 670 680 690 700 710 720 TKEETKVTAE KKTQKADERE GDQLPGNSKA DSKITESDTI QEKDQNSKKD TSDKNAGRIP 730 740 750 760 770 780 IKFNFTSRAV RRSTRSAVKA KGGVFEEDED EDKPLSELQT LCDEKEATVS ESEEDQAPPV 790 800 810 820 830 840 TRSKSREGCP VEERLEENKV GQLSSVHTET STTRARSSQN RENLFENTLR KEFKIDQESE 850 860 870 880 890 900 SDSGAELSLM SLGDAPSLYP ENILESQVEM ELLANAFSST DTEAETEIVL DTTGESDNFV 910 920 930 940 950 960 MEGKEEDDSP KQEESDDVDM DVDMEVEEQL HDVSTIVVSS PPHIPDEEGT DTDTDVQLSN 970 980 990 1000 1010 1020 SPSPSPSPRE NSRTCSEEMP IAPEEQTRSE IDGNEKQSQN GRLQENKDII IHETRIVPEI 1030 1040 1050 1060 1070 1080 KIVPAPDESC YQVRSEKAEE STEEKESEIN TSFETEQSDV ESLSLAKTSD FSKTESESED 1090 1100 1110 1120 1130 1140 AMSMEIIDLM AGTSYKTSKI SVNLPNEESD LNTSIQDVSD KIADNDEETI CDQTSVMLLE 1150 1160 1170 1180 1190 1200 EVTSVSQPAQ PPISDSQDPD VNAETIVLDR STSDQNITVQ GADKAKASSE VVISDELIMP 1210 1220 1230 1240 1250 1260 SIDIVNKSLP SEKGTIEVFN KESAINHDEL VETNTMPSSD IPSAQHDDIT TQMVPPISAE 1270 1280 1290 1300 1310 1320 STEISSTQEP VIAVNEQPTK HVIQEGPVGS KRKRKSRWAA FVPEVSVKPP TLSQMDVSVV 1330 1340 1350 1360 1370 1380 QTPQGYPSMI NMSSNSVFQP QTEEHQIKES RVEVNTPEES KSAHVESHIE EQSVDSPKLE 1390 1400 1410 1420 1430 1440 EETLSPSKRV RVHLDRMVIA AADQLSHDNS THNMTLDPWV IGKTEATYLS SGLDLEVNGA 1450 1460 1470 1480 1490 1500 GDNQAMIKLE DIAKNHEAGI INEEIEDAGE VMEPQPGAGE DSMEEGELDS DIKEETDEKP 1510 1520 1530 1540 1550 1560 CNDITGMEQG EIDDDGEGGV EERRQKQKSR HSRQDKENIP QNEYWAEEGK REERERPKEE 1570 1580 1590 1600 1610 1620 TRESREERRR LQYAEWGIVE RSKMPRFVEL NENYYLTERR RSKAGKEARR MVCCCATSRE 1630 1640 1650 1660 1670 1680 ERRRGIQACG EDCLNRVLML ECGSRCPCGD YCTNRRFQKR ENARVGVFYT EEKGHGLKAK 1690 1700 1710 1720 1730 1740 EELKDNEFVM EYVGEVLNFH EFKHRAKQYS KDKNLHFYFM ALKSDEIIDA TEKGNVSRFM 1750 1760 1770 1780 1790 1800 NHSCDPNCET QKWTVNGQLR VGFFTKRQVK PGEELTFDYQ FEVYGQEAQK CLCGSEKCRG 1810 1820 1830 1840 1850 1860 VIGKQKKQKE GKDTTPKRRG SFGEKRRKEA FTDITLEDEI QQMVDECDEC GLESNDHTIA 1870 1880 1890 1900 1910 1920 LSRFMVRADQ PKQRLALLQL LQETTEQAYL KYFLTHHGLK LIWSWMVDLG DSPAELQMQI 1930 1940 1950 1960 1970 1980 LLTLAKLPIP NKNALEDSKV LSVIERWARN FANQGPTQEM TSATKADSDV DSSSASETPS 1990 2000 2010 2020 2030 2040 RSDTPISAAM ASSLNVNSSI EMLKSIAEAT SSESDMDSET PSGVPLALRQ RLEAESMESP 2050 2060 2070 2080 2090 2100 TSTGSEGESM EKPTSSAGED SQNEQQEDVL LGQPDSASDA ATSTTTVEES VSKDKENSLS 2110 2120 2130 2140 2150 2160 ETLAFDSAVV DSTETGLPET TESSDDSSKE VRTLKSLAAD ATRHVQSQNS STDAQADVAI 2170 2180 2190 2200 2210 2220 SQSEDIVSES STSPAEESVM ASTSESENRT KDVEQPPSVA VETDNEAESK TDEGEKGGDS 2230 2240 2250 2260 2270 2280 EISIILSSLL SSWSDLKEIY RIPKKESEKD RDKDRERDRH REHDRDRDRK HDRDRDYDRD 2290 2300 2310 2320 2330 2340 HRDRDRDYGR DRDRGRDRDD RHHRDRGRDG DRDRHRDKER KDRDKSDDKS RRKRSRSRSR 2350 2360 2370 2380 2390 2400 ERETKSSWSK DSDTNATPPK LRKPWKDAKG KEGKGVVKED VKFEKESKKM SKEERRHLFE 2410 2420 2430 2440 2450 2460 MQVEAKERED AARKEQEAVM MAQWQESEQQ RQQQMAQYID ANGFPIDPNA PPHGMMVNEH 2470 2480 2490 2500 2510 2520 GMPIEVIPGH MGGMPPMGEQ YMGHHPDMPH PDMAFPPEHM HPDMQGQFPE LMQQHEHMGM 2530 2540 2550 2560 2570 2580 EERYHPSMHE HHMMPHEGQP MYDDSGFPIP PQEHMHPGMM GMPPHEGMPP HEGMPHPGAM 2590 2600 2610 2620 2630 2640 PHPGMDYQIH PDMDPNAMVH PHAEHLNMDP HMMGAQLHPN MDVHLLGGQP HPGDPNMYPP 2650 2660 2670 2680 2690 2700 EQHMMQPPVE AVPSQEVHVP QVVPIPAAGV AQVPSQSAPR EEDLMPPPML PVPSRKSKKS 2710 2720 2730 2740 2750 2760 KSQKSAAKQS SKTSPPSTTY VAPAAPASSG IPVLSSNVPS SSVVSVNQQG YPIAQAAPGI 2770 2780 2790 2800 2810 2820 VPMAQAPQVL QTPVLPQAPQ QAAQTTFTFV TPDGMLVTQT IVPLAATEQG ISPHVQPMQQ 2830 2840 2850 2860 2870 2880 HQQQMAGVQQ QQQQQQPQVT ESIPSPPAKP KTAKLPANWK TAQDAEGKVY YYHSVTRQTQ 2890 2900 2910 2920 2930 2940 WELPSWDEDE DDMYDDETGG ESNTPTYDEK GRPKTTTALA DTSSEAAKRL KEAFRSRMSH 2950 2960 2970 2980 2990 3000 HVVGYLNAYR KPDCKLGRIT NTEDFKHLAR KLTHGIMAKE LKHCRNIEDL EVNENVKHKA 3010 3020 KEYIRKYMGR YGKLYKKDPA DTDI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Deng J., Liu Y., Angeri F., Arias F., Bandaranaike D., Bess C., Blankenburg K., Chen D., Deiros R.D.R., Denson S., Dinh H., Francisco L., Fu Q., Gubbala S., Han Y., Hiang H., Javaid M., Jayaseelan J.C. , Jing C., Jones J., Korchina V., Lara F., Lee S., Li H., Mims S., Munidasa M., Ngo R., Nguyen L., Ongeri F., Osuji N., Palculict T., Patil S., Paul S., Pellon M., Perales L., Pu L., Puazo M., Qin X., Qu C., Raj R., Saada N., Shafer J., Shah N., Song H., Tang L., Vee V., Wang Y., Weissenberger G., Xin Y., Nazareth L., Newsham I., Wang M., Wu Y., Worley K.C., Reid J.G., Han Y., Muzny D.M., Gibbs R. Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	EnsemblMetazoa Submitted (DEC-2012) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
RefSeq	XP_783359.3. XM_778266.3.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	SPU_004588tr; SPU_004588tr; SPU_004588gn.
GeneID	578079.
KEGG	spu:578079.
Phylogenomic databases
KO	K11423.
OMA	MPPHEGM.
Family and domain databases
InterPro	IPR006560. AWS. IPR003616. Post-SET_dom. IPR001214. SET_dom. IPR013257. SRI. IPR001202. WW_dom. [Graphical view]
Pfam	PF00856. SET. 1 hit. PF08236. SRI. 1 hit. PF00397. WW. 1 hit. [Graphical view]
SMART	SM00570. AWS. 1 hit. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. SM00456. WW. 1 hit. [Graphical view]
SUPFAM	SSF51045. WW_Rsp5_WWP. 1 hit.
PROSITE	PS51215. AWS. 1 hit. PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. PS01159. WW_DOMAIN_1. 1 hit. PS50020. WW_DOMAIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

H3HSC8_STRPU

Accession

Primary (citable) accession number: H3HSC8

Entry history

Integrated into UniProtKB/TrEMBL:	April 18, 2012
Last sequence update:	April 18, 2012
Last modified:	May 1, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)