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Protein
Submitted name:

Interferon regulatory factor 8

Gene

IRF8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Interferon regulatory factor 8Imported
Gene namesi
Name:IRF8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:5358. IRF8.

PTM / Processingi

Proteomic databases

PaxDbiH3BRT4.

Expressioni

Gene expression databases

BgeeiH3BRT4.
ExpressionAtlasiH3BRT4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000268638.

Structurei

3D structure databases

ProteinModelPortaliH3BRT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IED8. Eukaryota.
ENOG410XNYR. LUCA.
GeneTreeiENSGT00760000119093.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
InterProiIPR019471. Interferon_reg_factor-3.
IPR017855. SMAD_dom-like.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF10401. IRF-3. 1 hit.
[Graphical view]
SMARTiSM01243. IRF-3. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.

Sequencei

Sequence statusi: Fragment.

H3BRT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVISFYYGGK LVGQATTTCP EGCRLSLSQP GLPGTKLYGP EGLELVRFPP
60 70 80 90 100
ADAIPSERQR QVTRKLFGHL ERGVLLHSSR QGVFVKRLCQ GRVFCSGNAV
110 120 130 140 150
VCKGRPNKLE RDEVVQVFDT SQFFRELQQF YNSQGRLPDG RVVLCFGEEF
160 170 180 190 200
PDMAPLRSKL ILVQIEQLYV RQLAEEAGKS CGAGSVMQAP EEPPPDQVFR
210 220
MFPDICASHQ RSFFRENQQI
Length:220
Mass (Da):24,728
Last modified:April 18, 2012 - v1
Checksum:i0EE8DFCA6D8A2045
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei220 – 2201Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092723 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000569607; ENSP00000456395; ENSG00000140968.
UCSCiuc059ybd.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092723 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliH3BRT4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000268638.

Proteomic databases

PaxDbiH3BRT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000569607; ENSP00000456395; ENSG00000140968.
UCSCiuc059ybd.1. human.

Organism-specific databases

HGNCiHGNC:5358. IRF8.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IED8. Eukaryota.
ENOG410XNYR. LUCA.
GeneTreeiENSGT00760000119093.

Miscellaneous databases

ChiTaRSiIRF8. human.
NextBioi35526751.

Gene expression databases

BgeeiH3BRT4.
ExpressionAtlasiH3BRT4. baseline and differential.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
InterProiIPR019471. Interferon_reg_factor-3.
IPR017855. SMAD_dom-like.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF10401. IRF-3. 1 hit.
[Graphical view]
SMARTiSM01243. IRF-3. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH3BRT4_HUMAN
AccessioniPrimary (citable) accession number: H3BRT4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: May 11, 2016
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.