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Protein
Submitted name:

Interferon regulatory factor 8

Gene

IRF8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Interferon regulatory factor 8Imported
Gene namesi
Name:IRF8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000140968.10.
HGNCiHGNC:5358. IRF8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140968.

PTM / Processingi

Proteomic databases

MaxQBiH3BRT4.
PaxDbiH3BRT4.
PeptideAtlasiH3BRT4.
PRIDEiH3BRT4.

Expressioni

Gene expression databases

BgeeiENSG00000140968.
ExpressionAtlasiH3BRT4. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH3BRT4.
SMRiH3BRT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 178IRF-3InterPro annotationAdd BLAST178

Phylogenomic databases

eggNOGiENOG410IED8. Eukaryota.
ENOG410XNYR. LUCA.
GeneTreeiENSGT00760000119093.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
InterProiView protein in InterPro
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR019471. Interferon_reg_factor-3.
IPR017855. SMAD-like_dom_sf.
IPR008984. SMAD_FHA_dom_sf.
PANTHERiPTHR11949. PTHR11949. 1 hit.
PfamiView protein in Pfam
PF10401. IRF-3. 1 hit.
SMARTiView protein in SMART
SM01243. IRF-3. 1 hit.
SUPFAMiSSF49879. SSF49879. 1 hit.

Sequencei

Sequence statusi: Fragment.

H3BRT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVISFYYGGK LVGQATTTCP EGCRLSLSQP GLPGTKLYGP EGLELVRFPP
60 70 80 90 100
ADAIPSERQR QVTRKLFGHL ERGVLLHSSR QGVFVKRLCQ GRVFCSGNAV
110 120 130 140 150
VCKGRPNKLE RDEVVQVFDT SQFFRELQQF YNSQGRLPDG RVVLCFGEEF
160 170 180 190 200
PDMAPLRSKL ILVQIEQLYV RQLAEEAGKS CGAGSVMQAP EEPPPDQVFR
210 220
MFPDICASHQ RSFFRENQQI
Length:220
Mass (Da):24,728
Last modified:April 18, 2012 - v1
Checksum:i0EE8DFCA6D8A2045
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei220Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092723 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000569607; ENSP00000456395; ENSG00000140968.
UCSCiuc059ybd.1. human.

Similar proteinsi

Entry informationi

Entry nameiH3BRT4_HUMAN
AccessioniPrimary (citable) accession number: H3BRT4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: November 22, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported