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Protein

Sulfhydryl oxidase

Gene

GFER

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.UniRule annotation

Cofactori

FADUniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidaseUniRule annotation (EC:1.8.3.2UniRule annotation)
Gene namesi
Name:GFERImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000127554.12
HGNCiHGNC:4236 GFER

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127554

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi129 ↔ 132Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

MaxQBiH3BRD2
PeptideAtlasiH3BRD2
PRIDEiH3BRD2

Expressioni

Gene expression databases

BgeeiENSG00000127554
ExpressionAtlasiH3BRD2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH3BRD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 139ERV/ALR sulfhydryl oxidaseInterPro annotationAdd BLAST58

Phylogenomic databases

eggNOGiKOG3355 Eukaryota
COG5054 LUCA
GeneTreeiENSGT00390000001979

Family and domain databases

Gene3Di1.20.120.310, 1 hit
InterProiView protein in InterPro
IPR036774 ERV/ALR_sulphydryl_oxid_sf
IPR017905 ERV/ALR_sulphydryl_oxidase
PfamiView protein in Pfam
PF04777 Evr1_Alr, 1 hit
SUPFAMiSSF69000 SSF69000, 1 hit
PROSITEiView protein in PROSITE
PS51324 ERV_ALR, 1 hit

Sequencei

Sequence statusi: Fragment.

H3BRD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NLFFLPGGAR SEMMDDLATD ARGRGAGRRD AAASASTPAQ APTSDSPVAE
60 70 80 90 100
DASRRRPCRA CVDFKTWMRT QQKRDTKFRE DCPPDREELG RHSWAVLHTL
110 120 130
AAYYPDLPTP EQQQDMAQFI HLFSKFYPCE ECAEDLRKR
Length:139
Mass (Da):15,796
Last modified:April 18, 2012 - v1
Checksum:iA4F3F47705A11776
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005606 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000561710; ENSP00000456189; ENSG00000127554
UCSCiuc059pee.1 human

Similar proteinsi

Entry informationi

Entry nameiH3BRD2_HUMAN
AccessioniPrimary (citable) accession number: H3BRD2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: March 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health