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Protein
Submitted name:

Interferon regulatory factor 8

Gene

IRF8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Interferon regulatory factor 8Imported
Gene namesi
Name:IRF8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000140968.10
HGNCiHGNC:5358 IRF8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140968

PTM / Processingi

Proteomic databases

PeptideAtlasiH3BQK3
PRIDEiH3BQK3

Expressioni

Gene expression databases

BgeeiENSG00000140968
ExpressionAtlasiH3BQK3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH3BQK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 47IRF tryptophan pentad repeatInterPro annotationAdd BLAST41

Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IED8 Eukaryota
ENOG410XNYR LUCA
GeneTreeiENSGT00760000119093

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001346 Interferon_reg_fact_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11949 PTHR11949, 1 hit
PfamiView protein in Pfam
PF00605 IRF, 1 hit
PRINTSiPR00267 INTFRNREGFCT
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51507 IRF_2, 1 hit

Sequencei

Sequence statusi: Fragment.

H3BQK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MCDRNGGRRL RQWLIEQIDS SMYPGLIWEN EEKSMFRIPW KHAGKQD
Length:47
Mass (Da):5,708
Last modified:April 18, 2012 - v1
Checksum:i13CD91108B3119DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei47Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092723 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000565552; ENSP00000455816; ENSG00000140968
UCSCiuc059yav.1 human

Similar proteinsi

Entry informationi

Entry nameiH3BQK3_HUMAN
AccessioniPrimary (citable) accession number: H3BQK3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: May 23, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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