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Protein

U6 snRNA phosphodiesterase

Gene

USB1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei69 – 691Proton donor/acceptorUniRule annotation
Active sitei157 – 1571Proton donor/acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, NucleaseUniRule annotation

Keywords - Biological processi

mRNA processing, mRNA splicingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA phosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Gene namesi
Name:USB1UniRule annotationImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25792. USB1.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiH3BNM8.
PeptideAtlasiH3BNM8.

Expressioni

Gene expression databases

BgeeiENSG00000103005.
ExpressionAtlasiH3BNM8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000219281.

Structurei

3D structure databases

ProteinModelPortaliH3BNM8.
SMRiH3BNM8. Positions 28-214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2H phosphoesterase superfamily. USB1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3102. Eukaryota.
ENOG4111KT5. LUCA.
GeneTreeiENSGT00390000004596.

Family and domain databases

HAMAPiMF_03040. USB1. 1 hit.
InterProiIPR027521. Usb1.
[Graphical view]
PANTHERiPTHR13522. PTHR13522. 1 hit.
PfamiPF09749. HVSL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H3BNM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPGTEEGPE DDSTKHGGRV RTFPHERGNW ATHVYVPYEA KEEFLDLLDV
60 70 80 90 100
LLPHAQTYVP RLVRMKVFHL SLSQSVVLRH HWILPFVQAL KARMTSFHRF
110 120 130 140 150
FFTANQVKIY TNQEKTRTFI GLEVTSGHAQ FLDLVSEVDR VMEEFNLTTF
160 170 180 190 200
YQDPSFHLSL AWCVGDARLQ LEGQCLQELQ AIVDGFEDAE VLLRVHTEQV
210
RCKSGNKFFS MPLK
Length:214
Mass (Da):24,814
Last modified:April 18, 2012 - v1
Checksum:i8BA7DFED0D127076
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010543 Genomic DNA. No translation available.
AC012182 Genomic DNA. No translation available.
RefSeqiXP_005256201.1. XM_005256144.3.
XP_011521631.1. XM_011523329.2.
UniGeneiHs.408702.

Genome annotation databases

EnsembliENST00000561743; ENSP00000454928; ENSG00000103005.
GeneIDi79650.
UCSCiuc059uyv.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010543 Genomic DNA. No translation available.
AC012182 Genomic DNA. No translation available.
RefSeqiXP_005256201.1. XM_005256144.3.
XP_011521631.1. XM_011523329.2.
UniGeneiHs.408702.

3D structure databases

ProteinModelPortaliH3BNM8.
SMRiH3BNM8. Positions 28-214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000219281.

Proteomic databases

PaxDbiH3BNM8.
PeptideAtlasiH3BNM8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000561743; ENSP00000454928; ENSG00000103005.
GeneIDi79650.
UCSCiuc059uyv.1. human.

Organism-specific databases

CTDi79650.
HGNCiHGNC:25792. USB1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3102. Eukaryota.
ENOG4111KT5. LUCA.
GeneTreeiENSGT00390000004596.

Miscellaneous databases

GenomeRNAii79650.

Gene expression databases

BgeeiENSG00000103005.
ExpressionAtlasiH3BNM8. baseline and differential.

Family and domain databases

HAMAPiMF_03040. USB1. 1 hit.
InterProiIPR027521. Usb1.
[Graphical view]
PANTHERiPTHR13522. PTHR13522. 1 hit.
PfamiPF09749. HVSL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH3BNM8_HUMAN
AccessioniPrimary (citable) accession number: H3BNM8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 7, 2016
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.