Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

H3BNM8

- H3BNM8_HUMAN

UniProt

H3BNM8 - H3BNM8_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

U6 snRNA phosphodiesterase

Gene

USB1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei69 – 691Proton donor/acceptorUniRule annotation
Active sitei157 – 1571Proton donor/acceptorUniRule annotation

GO - Molecular functioni

  1. nuclease activity Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. RNA splicing Source: UniProtKB-HAMAP
  3. U6 snRNA 3'-end processing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, NucleaseUniRule annotation

Keywords - Biological processi

mRNA processing, mRNA splicingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA phosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Gene namesi
Name:USB1UniRule annotationImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:25792. USB1.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiH3BNM8.
ExpressionAtlasiH3BNM8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH3BNM8.
SMRiH3BNM8. Positions 28-214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the USB1 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000004596.
OrthoDBiEOG79W972.

Family and domain databases

HAMAPiMF_03040. USB1.
InterProiIPR027521. Usb1.
[Graphical view]
PANTHERiPTHR13522. PTHR13522. 1 hit.
PfamiPF09749. HVSL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H3BNM8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPGTEEGPE DDSTKHGGRV RTFPHERGNW ATHVYVPYEA KEEFLDLLDV
60 70 80 90 100
LLPHAQTYVP RLVRMKVFHL SLSQSVVLRH HWILPFVQAL KARMTSFHRF
110 120 130 140 150
FFTANQVKIY TNQEKTRTFI GLEVTSGHAQ FLDLVSEVDR VMEEFNLTTF
160 170 180 190 200
YQDPSFHLSL AWCVGDARLQ LEGQCLQELQ AIVDGFEDAE VLLRVHTEQV
210
RCKSGNKFFS MPLK
Length:214
Mass (Da):24,814
Last modified:April 18, 2012 - v1
Checksum:i8BA7DFED0D127076
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC010543 Genomic DNA. No translation available.
AC012182 Genomic DNA. No translation available.
RefSeqiXP_005256201.1. XM_005256144.2.
UniGeneiHs.408702.

Genome annotation databases

EnsembliENST00000561743; ENSP00000454928; ENSG00000103005.
GeneIDi79650.
KEGGihsa:79650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC010543 Genomic DNA. No translation available.
AC012182 Genomic DNA. No translation available.
RefSeqi XP_005256201.1. XM_005256144.2.
UniGenei Hs.408702.

3D structure databases

ProteinModelPortali H3BNM8.
SMRi H3BNM8. Positions 28-214.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000561743 ; ENSP00000454928 ; ENSG00000103005 .
GeneIDi 79650.
KEGGi hsa:79650.

Organism-specific databases

CTDi 79650.
HGNCi HGNC:25792. USB1.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00390000004596.
OrthoDBi EOG79W972.

Miscellaneous databases

GenomeRNAii 79650.
NextBioi 35525866.

Gene expression databases

Bgeei H3BNM8.
ExpressionAtlasi H3BNM8. baseline and differential.

Family and domain databases

HAMAPi MF_03040. USB1.
InterProi IPR027521. Usb1.
[Graphical view ]
PANTHERi PTHR13522. PTHR13522. 1 hit.
Pfami PF09749. HVSL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH3BNM8_HUMAN
AccessioniPrimary (citable) accession number: H3BNM8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: October 29, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3