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H3BNM8

- H3BNM8_HUMAN

UniProt

H3BNM8 - H3BNM8_HUMAN

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Protein
U6 snRNA phosphodiesterase
Gene
USB1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei69 – 691Proton donor/acceptor By similarityUniRule annotation
Active sitei157 – 1571Proton donor/acceptor By similarityUniRule annotation

GO - Molecular functioni

  1. nuclease activity Source: UniProtKB-KW

GO - Biological processi

  1. RNA splicing Source: UniProtKB-HAMAP
  2. U6 snRNA 3'-end processing Source: UniProtKB-HAMAP
  3. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, NucleaseUniRule annotation

Keywords - Biological processi

mRNA processing, mRNA splicingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA phosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Gene namesi
Name:USB1UniRule annotationImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:25792. USB1.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

ArrayExpressiH3BNM8.
BgeeiH3BNM8.

Structurei

3D structure databases

ProteinModelPortaliH3BNM8.
SMRiH3BNM8. Positions 28-214.

Family & Domainsi

Sequence similaritiesi

Belongs to the USB1 family.UniRule annotation

Phylogenomic databases

OrthoDBiEOG79W972.

Family and domain databases

HAMAPiMF_03040. USB1.
InterProiIPR027521. Usb1.
[Graphical view]
PANTHERiPTHR13522. PTHR13522. 1 hit.
PfamiPF09749. HVSL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H3BNM8-1 [UniParc]FASTAAdd to Basket

« Hide

MFPGTEEGPE DDSTKHGGRV RTFPHERGNW ATHVYVPYEA KEEFLDLLDV    50
LLPHAQTYVP RLVRMKVFHL SLSQSVVLRH HWILPFVQAL KARMTSFHRF 100
FFTANQVKIY TNQEKTRTFI GLEVTSGHAQ FLDLVSEVDR VMEEFNLTTF 150
YQDPSFHLSL AWCVGDARLQ LEGQCLQELQ AIVDGFEDAE VLLRVHTEQV 200
RCKSGNKFFS MPLK 214
Length:214
Mass (Da):24,814
Last modified:April 18, 2012 - v1
Checksum:i8BA7DFED0D127076
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC010543 Genomic DNA. No translation available.
AC012182 Genomic DNA. No translation available.
RefSeqiXP_005256201.1. XM_005256144.2.
UniGeneiHs.408702.

Genome annotation databases

EnsembliENST00000561743; ENSP00000454928; ENSG00000103005.
GeneIDi79650.
KEGGihsa:79650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC010543 Genomic DNA. No translation available.
AC012182 Genomic DNA. No translation available.
RefSeqi XP_005256201.1. XM_005256144.2.
UniGenei Hs.408702.

3D structure databases

ProteinModelPortali H3BNM8.
SMRi H3BNM8. Positions 28-214.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000561743 ; ENSP00000454928 ; ENSG00000103005 .
GeneIDi 79650.
KEGGi hsa:79650.

Organism-specific databases

CTDi 79650.
HGNCi HGNC:25792. USB1.
GenAtlasi Search...

Phylogenomic databases

OrthoDBi EOG79W972.

Miscellaneous databases

GenomeRNAii 79650.
NextBioi 35525866.

Gene expression databases

ArrayExpressi H3BNM8.
Bgeei H3BNM8.

Family and domain databases

HAMAPi MF_03040. USB1.
InterProi IPR027521. Usb1.
[Graphical view ]
PANTHERi PTHR13522. PTHR13522. 1 hit.
Pfami PF09749. HVSL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH3BNM8_HUMAN
AccessioniPrimary (citable) accession number: H3BNM8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: July 9, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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