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H3BNM8 (H3BNM8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate By similarity. HAMAP-Rule MF_03040

Subcellular location

Nucleus By similarity HAMAP-Rule MF_03040.

Sequence similarities

Belongs to the USB1 family. HAMAP-Rule MF_03040

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000454928

Ontologies

Keywords
   Biological processmRNA processing
mRNA splicing HAMAP-Rule MF_03040
   Cellular componentNucleus HAMAP-Rule MF_03040
   Molecular functionHydrolase
Nuclease HAMAP-Rule MF_03040
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA splicing

Inferred from electronic annotation. Source: UniProtKB-HAMAP

U6 snRNA 3'-end processing

Inferred from electronic annotation. Source: UniProtKB-HAMAP

mRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionnuclease activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site691Proton donor/acceptor By similarity HAMAP-Rule MF_03040
Active site1571Proton donor/acceptor By similarity HAMAP-Rule MF_03040

Sequences

Sequence LengthMass (Da)Tools
H3BNM8 [UniParc].

Last modified April 18, 2012. Version 1.
Checksum: 8BA7DFED0D127076

FASTA21424,814
        10         20         30         40         50         60 
MFPGTEEGPE DDSTKHGGRV RTFPHERGNW ATHVYVPYEA KEEFLDLLDV LLPHAQTYVP 

        70         80         90        100        110        120 
RLVRMKVFHL SLSQSVVLRH HWILPFVQAL KARMTSFHRF FFTANQVKIY TNQEKTRTFI 

       130        140        150        160        170        180 
GLEVTSGHAQ FLDLVSEVDR VMEEFNLTTF YQDPSFHLSL AWCVGDARLQ LEGQCLQELQ 

       190        200        210 
AIVDGFEDAE VLLRVHTEQV RCKSGNKFFS MPLK 

« Hide

References

« Hide 'large scale' references
[1]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC010543 Genomic DNA. No translation available.
AC012182 Genomic DNA. No translation available.
RefSeqXP_005256201.1. XM_005256144.2.
UniGeneHs.408702.

3D structure databases

ProteinModelPortalH3BNM8.
SMRH3BNM8. Positions 28-214.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000561743; ENSP00000454928; ENSG00000103005.
GeneID79650.
KEGGhsa:79650.

Organism-specific databases

CTD79650.
HGNCHGNC:25792. USB1.
GenAtlasSearch...

Phylogenomic databases

OrthoDBEOG79W972.

Gene expression databases

ArrayExpressH3BNM8.
BgeeH3BNM8.

Family and domain databases

HAMAPMF_03040. USB1.
InterProIPR027521. Usb1.
[Graphical view]
PANTHERPTHR13522. PTHR13522. 1 hit.
PfamPF09749. HVSL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79650.
NextBio35525866.

Entry information

Entry nameH3BNM8_HUMAN
AccessionPrimary (citable) accession number: H3BNM8
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: July 9, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.