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H3BNM8

- H3BNM8_HUMAN

UniProt

H3BNM8 - H3BNM8_HUMAN

Protein

U6 snRNA phosphodiesterase

Gene

USB1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei69 – 691Proton donor/acceptorUniRule annotation
    Active sitei157 – 1571Proton donor/acceptorUniRule annotation

    GO - Molecular functioni

    1. nuclease activity Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. RNA splicing Source: UniProtKB-HAMAP
    3. U6 snRNA 3'-end processing Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, NucleaseUniRule annotation

    Keywords - Biological processi

    mRNA processing, mRNA splicingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U6 snRNA phosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
    Gene namesi
    Name:USB1UniRule annotationImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:25792. USB1.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Expressioni

    Gene expression databases

    ArrayExpressiH3BNM8.
    BgeeiH3BNM8.

    Structurei

    3D structure databases

    ProteinModelPortaliH3BNM8.
    SMRiH3BNM8. Positions 28-214.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the USB1 family.UniRule annotation

    Phylogenomic databases

    OrthoDBiEOG79W972.

    Family and domain databases

    HAMAPiMF_03040. USB1.
    InterProiIPR027521. Usb1.
    [Graphical view]
    PANTHERiPTHR13522. PTHR13522. 1 hit.
    PfamiPF09749. HVSL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H3BNM8-1 [UniParc]FASTAAdd to Basket

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    MFPGTEEGPE DDSTKHGGRV RTFPHERGNW ATHVYVPYEA KEEFLDLLDV    50
    LLPHAQTYVP RLVRMKVFHL SLSQSVVLRH HWILPFVQAL KARMTSFHRF 100
    FFTANQVKIY TNQEKTRTFI GLEVTSGHAQ FLDLVSEVDR VMEEFNLTTF 150
    YQDPSFHLSL AWCVGDARLQ LEGQCLQELQ AIVDGFEDAE VLLRVHTEQV 200
    RCKSGNKFFS MPLK 214
    Length:214
    Mass (Da):24,814
    Last modified:April 18, 2012 - v1
    Checksum:i8BA7DFED0D127076
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC010543 Genomic DNA. No translation available.
    AC012182 Genomic DNA. No translation available.
    RefSeqiXP_005256201.1. XM_005256144.2.
    UniGeneiHs.408702.

    Genome annotation databases

    EnsembliENST00000561743; ENSP00000454928; ENSG00000103005.
    GeneIDi79650.
    KEGGihsa:79650.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC010543 Genomic DNA. No translation available.
    AC012182 Genomic DNA. No translation available.
    RefSeqi XP_005256201.1. XM_005256144.2.
    UniGenei Hs.408702.

    3D structure databases

    ProteinModelPortali H3BNM8.
    SMRi H3BNM8. Positions 28-214.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000561743 ; ENSP00000454928 ; ENSG00000103005 .
    GeneIDi 79650.
    KEGGi hsa:79650.

    Organism-specific databases

    CTDi 79650.
    HGNCi HGNC:25792. USB1.
    GenAtlasi Search...

    Phylogenomic databases

    OrthoDBi EOG79W972.

    Miscellaneous databases

    GenomeRNAii 79650.
    NextBioi 35525866.

    Gene expression databases

    ArrayExpressi H3BNM8.
    Bgeei H3BNM8.

    Family and domain databases

    HAMAPi MF_03040. USB1.
    InterProi IPR027521. Usb1.
    [Graphical view ]
    PANTHERi PTHR13522. PTHR13522. 1 hit.
    Pfami PF09749. HVSL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiH3BNM8_HUMAN
    AccessioniPrimary (citable) accession number: H3BNM8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2012
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3