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Protein
Submitted name:

PH domain leucine-rich repeat-containing protein phosphatase 2

Gene

PHLPP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
PH domain leucine-rich repeat-containing protein phosphatase 2Imported
Gene namesi
Name:PHLPP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000040199.18.
HGNCiHGNC:29149. PHLPP2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000040199.

PTM / Processingi

Proteomic databases

MaxQBiH3BMS5.
PaxDbiH3BMS5.
PeptideAtlasiH3BMS5.
PRIDEiH3BMS5.

Expressioni

Gene expression databases

BgeeiENSG00000040199.
ExpressionAtlasiH3BMS5. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH3BMS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini820 – 1068PPM-type phosphataseInterPro annotationAdd BLAST249

Phylogenomic databases

eggNOGiKOG0618. Eukaryota.
KOG0619. Eukaryota.
COG0631. LUCA.
COG4886. LUCA.
GeneTreeiENSGT00440000037833.
OMAiLGMAGQK.
OrthoDBiEOG091G03A3.

Family and domain databases

CDDicd00143. PP2Cc. 1 hit.
Gene3Di2.30.29.30. 1 hit.
3.60.40.10. 1 hit.
3.80.10.10. 5 hits.
InterProiView protein in InterPro
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032675. LRR_dom_sf.
IPR011993. PH-like_dom_sf.
IPR036457. PPM-type_dom_sf.
IPR001932. PPM-type_phosphatase_dom.
PfamiView protein in Pfam
PF13855. LRR_8. 2 hits.
PF00481. PP2C. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 13 hits.
SM00332. PP2Cc. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52058. SSF52058. 2 hits.
SSF81606. SSF81606. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 18 hits.
PS51746. PPM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

H3BMS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEVEPGPAG PLEPPEPPEA PASRRPGGIR VLKRNMKRNG SRNCLNRRSR
60 70 80 90 100
FGSRERDWLR EDVKRGCVYL YGADTTTATT TTTTSSSSSS SSSSSDLHLV
110 120 130 140 150
LCTVETPASE ICAGEGRESL YLQLHGDLVR RLEPTERPLQ IVYDYLSRLG
160 170 180 190 200
FDDPVRIQEE ATNPDLGCMI RFYGEKPCHM DRLDRILLSG IYNVRKGKTQ
210 220 230 240 250
LHKWAERLVV LCGTCLIVSS VKDCQTGKMH ILPLVGGKIE EVKRRQYSLA
260 270 280 290 300
FSSAGAQAQT YHVSFETLAE YQRWQRQASK VVSQRISTVD LSCYSLEEVP
310 320 330 340 350
EHLFYSQDIT YLNLRHNFMQ LERPGGLDTL YKFSQLKGLN LSHNKLGLFP
360 370 380 390 400
ILLCEISTLT ELNLSCNGFH DLPSQIGNLL NLQTLCLDGN FLTTLPEELG
410 420 430 440 450
NLQQLSSLGI SFNNFSQIPE VYEKLTMLDR VVMAGNCLEV LNLGVLNRMN
460 470 480 490 500
HIKHVDLRMN HLKTMVIENL EGNKHITHVD LRDNRLTDLD LSSLCSLEQL
510 520 530 540 550
HCGRNQLREL TLSGFSLRTL YASSNRLTAV NVYPVPSLLT FLDLSRNLLE
560 570 580 590 600
CVPDWACEAK KIEVLDVSYN LLTEVPVRIL SSLSLRKLML GHNHVQNLPT
610 620 630 640 650
LVEHIPLEVL DLQHNALTRL PDTLFSKALN LRYLNASANS LESLPSACTG
660 670 680 690 700
EESLSMLQLL YLTNNLLTDQ CIPVLVGHLH LRILHLANNQ LQTFPASKLN
710 720 730 740 750
KLEQLEELNL SGNKLKTIPT TIANCKRLHT LVAHSNNISI FPEILQLPQI
760 770 780 790 800
QFVDLSCNDL TEILIPEALP ATLQDLDLTG NTNLVLEHKT LDIFSHITTL
810 820 830 840 850
KIDQKPLPTT DSTVTSTFWS HGLAEMAGQR NKLCVSALAM DSFAEGVGAV
860 870 880 890 900
YGMFDGDRNE ELPRLLQCTM ADVLLEEVQQ STNDTVFMAN TFLVSHRKLG
910 920 930 940 950
MAGQKLGSSA LLCYIRPDTA DPASSFSLTV ANVGTCQAVL CRGGKPVPLS
960 970 980 990 1000
KVFSLEQDPE EAQRVKDQKA IITEDNKVNG VTCCTRMLGC TYLYPWILPK
1010 1020 1030 1040 1050
PHISSTPLTI QDELLILGNK ALWEHLSYTE AVNAVRHVQD PLAAAKKLCT
1060 1070 1080 1090 1100
LAQSYGCQDN VGAMVVYLNI GEEGCTCEMN GLTLPGPVGF ASTTTIKDAP
1110 1120 1130 1140 1150
KPATPSSSSG IASEFSSEMS TSEVSSEVGS TASDEHNAGG LDTALLPRPE
1160 1170 1180 1190 1200
RRCSLHPTPT SGLFQRQPSS ATFSSNQSDN GLDSDDDQPV EGVITNGSKV
1210 1220 1230 1240 1250
EVEVDIHCCR GRDLENSPPL IESSPTLCSE EHARGSCFGI RRQNSVNSGM
1260 1270 1280 1290 1300
LLPMSKDRME LQKSPSTSCL YGKKLSNGSI VPLEDSLNLI EVATEVPKRK
1310 1320 1330 1340 1350
TGYFAAPTQM EPEDQFVVPH DLEEEVKEQM KQHQDSRLEP EPHEEDRTEP

PEEFDTAL
Length:1,358
Mass (Da):150,392
Last modified:April 18, 2012 - v1
Checksum:i166454C45D2DEBC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009097 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000567016; ENSP00000454519; ENSG00000040199.
UCSCiuc059wuv.1. human.

Similar proteinsi

Entry informationi

Entry nameiH3BMS5_HUMAN
AccessioniPrimary (citable) accession number: H3BMS5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: November 22, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported