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Protein

Homeobox protein cut-like

Gene

Cux1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein cut-likeUniRule annotation
Gene namesi
Name:Cux1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:88568. Cux1.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiH3BLS0.
PaxDbiH3BLS0.
PeptideAtlasiH3BLS0.
PRIDEiH3BLS0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029705.
ExpressionAtlasiH3BLS0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004097.

Structurei

3D structure databases

ProteinModelPortaliH3BLS0.
SMRiH3BLS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini534 – 621CUT DNA-bindingInterPro annotationAdd BLAST88
Domaini923 – 1010CUT DNA-bindingInterPro annotationAdd BLAST88
Domaini1106 – 1193CUT DNA-bindingInterPro annotationAdd BLAST88
Domaini1231 – 1291Homeobox DNA-bindingInterPro annotationAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili197 – 281Sequence analysisAdd BLAST85
Coiled coili286 – 313Sequence analysisAdd BLAST28
Coiled coili322 – 359Sequence analysisAdd BLAST38
Coiled coili379 – 438Sequence analysisAdd BLAST60

Sequence similaritiesi

Belongs to the CUT homeobox family.UniRule annotation
Contains 1 homeobox DNA-binding domain.UniRule annotation
Contains 3 CUT DNA-binding domains.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, HomeoboxUniRule annotation

Phylogenomic databases

eggNOGiKOG0963. Eukaryota.
KOG2252. Eukaryota.
ENOG410XPRP. LUCA.
GeneTreeiENSGT00530000063019.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProiIPR003350. CUT_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM01109. CUT. 3 hits.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEiPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H3BLS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERASGPLRA AFSSPVLESK APGAPLDCKE TDCGSSSPRG DGIGASQSAA
60 70 80 90 100
ELPACPEDAI LPATPHRNQL LALGVLPASA SSAFAAPGQP QDSARWMLCV
110 120 130 140 150
AGAKLKRELD ATATVLANRQ DESEQSRKRL IEQSREFKKN TPEDLRKQVA
160 170 180 190 200
PLLKSFQGEI DALSKRSKEA EAAFLTVYKR LIDVPDPVPA LDVGQQLEIK
210 220 230 240 250
VQRLHDIETE NQKLRETLEE YNKEFAEVKN QEVTIKALKE KIREYEQTLK
260 270 280 290 300
SQAETIALEK EQKLQNDFAE KERKLQETQM STTSKLEEAE HKLQTLQTAL
310 320 330 340 350
EKTRTELFDL KTKYDEETTA KADEIEMIMT DLERANQRAE VAQREAETLR
360 370 380 390 400
EQLSSANHSL QLASQIQKAP DVAIEVLTRS SLEVELAAKE REIAQLVEDV
410 420 430 440 450
QRLQASLTKL RENSASQISQ LEQQLNAKNS TLKQLEEKLK GQADYEEVKK
460 470 480 490 500
ELNTLKSMEF APSEGAGTQD STKPLEVLLL EKNRSLQSEN ATLRISNSDL
510 520 530 540 550
SGPYSTNSIS SPSPLQQSPD VNGMAPSPSQ SESAGSISEG EEIDTAEIAR
560 570 580 590 600
QVKEQLIKHN IGQRIFGHYV LGLSQGSVSE ILARPKPWNK LTVRGKEPFH
610 620 630 640 650
KMKQFLSDEQ NILALRSIQG RQRENPGQSL NRLFQEVPKR RNGSEGNITT
660 670 680 690 700
RIRASETGSD EAIKSILEQA KRELQVQKTA EPVQTSSTSS SGNSDDAIRS
710 720 730 740 750
ILQQARREME AQQAALDPAL KPAPLSQPDL TILTPKHLSA SPMSTVSTYP
760 770 780 790 800
PLAISLKKTP AAPETSTAAL PSAPALKKEA QDVPTLDPPG SADAAQGVLR
810 820 830 840 850
PMKSELVRGS TWKDPWWSPI QPERRNLTSS EETKADETTA SGKERAGSSQ
860 870 880 890 900
PRAERSQLQG PSASAEYWKE WPSAESPYSQ SSELSLTGAS RSETPQNSPL
910 920 930 940 950
PSSPIVPMAK PAKPSVPPLT PEQYEVYMYQ EVDTIELTRQ VKEKLAKNGI
960 970 980 990 1000
CQRIFGEKVL GLSQGSVSDM LSRPKPWSKL TQKGREPFIR MQLWLNGELG
1010 1020 1030 1040 1050
QGVLPVQGQQ QGPVLHSVAS LQDPLQQGCV SSESTPKTSA SCSPAPESPM
1060 1070 1080 1090 1100
SSSESVKSLT ELVQQPCPAI ETSKEGKPPE PSDPPASDSQ PTTPLPLSGH
1110 1120 1130 1140 1150
SALSIQELVA MSPELDTYGI TKRVKEVLTD NNLGQRLFGE TILGLTQGSV
1160 1170 1180 1190 1200
SDLLARPKPW HKLSLKGREP FVRMQLWLND PNNVEKLMDM KRMEKKAYMK
1210 1220 1230 1240 1250
RRHSSVSDSQ PCEPPSVGID YSQGASPQPQ HQLKKPRVVL APEEKEALKR
1260 1270 1280 1290 1300
AYQQKPYPSP KTIEELATQL NLKTSTVINW FHNYRSRIRR ELFIEEIQAG
1310 1320 1330 1340 1350
SQGQAGASDS PSARSSRAAP SSEGDSCDGV EATDAEEPGG NIVATKSQGG
1360 1370 1380 1390 1400
LAEVAAAPAD REEATQPAEK AKAQPLCSGT PGQDDGEDAS RPRPLPEGLA
1410 1420 1430 1440 1450
DAPAPVPSLA APAAGEDAAT SATAPATATE APGAARAGPA ERSSALPSTS
1460 1470 1480 1490 1500
APANAPARRP SSLQSLFGLP EAAGARDNLV RKKKAANLNS IIHRLEKAAS

REEPIEWEF
Length:1,509
Mass (Da):164,235
Last modified:April 18, 2012 - v1
Checksum:i32F26E6E439A5573
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC080158 Genomic DNA. No translation available.
AC083890 Genomic DNA. No translation available.
AC087329 Genomic DNA. No translation available.
RefSeqiXP_006504417.1. XM_006504354.2.
UniGeneiMm.320317.
Mm.436792.

Genome annotation databases

EnsembliENSMUST00000176778; ENSMUSP00000135892; ENSMUSG00000029705.
GeneIDi13047.
UCSCiuc009aao.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC080158 Genomic DNA. No translation available.
AC083890 Genomic DNA. No translation available.
AC087329 Genomic DNA. No translation available.
RefSeqiXP_006504417.1. XM_006504354.2.
UniGeneiMm.320317.
Mm.436792.

3D structure databases

ProteinModelPortaliH3BLS0.
SMRiH3BLS0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004097.

Proteomic databases

MaxQBiH3BLS0.
PaxDbiH3BLS0.
PeptideAtlasiH3BLS0.
PRIDEiH3BLS0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000176778; ENSMUSP00000135892; ENSMUSG00000029705.
GeneIDi13047.
UCSCiuc009aao.2. mouse.

Organism-specific databases

CTDi1523.
MGIiMGI:88568. Cux1.

Phylogenomic databases

eggNOGiKOG0963. Eukaryota.
KOG2252. Eukaryota.
ENOG410XPRP. LUCA.
GeneTreeiENSGT00530000063019.

Enzyme and pathway databases

ReactomeiR-MMU-6811438. Intra-Golgi traffic.

Miscellaneous databases

ChiTaRSiCux1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029705.
ExpressionAtlasiH3BLS0. baseline and differential.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProiIPR003350. CUT_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM01109. CUT. 3 hits.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEiPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH3BLS0_MOUSE
AccessioniPrimary (citable) accession number: H3BLS0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: November 2, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.