ID   H3BL52_MOUSE            Unreviewed;       618 AA.
AC   H3BL52;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=Low density lipoprotein receptor-related protein 5 {ECO:0000313|Ensembl:ENSMUSP00000135654.2};
GN   Name=Lrp5 {ECO:0000313|Ensembl:ENSMUSP00000135654.2,
GN   ECO:0000313|MGI:MGI:1278315};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000135654.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000135654.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000135654.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000135654.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000135654.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; H3BL52; -.
DR   SMR; H3BL52; -.
DR   MaxQB; H3BL52; -.
DR   ProteomicsDB; 304570; -.
DR   Antibodypedia; 4572; 486 antibodies from 37 providers.
DR   Ensembl; ENSMUST00000176867.2; ENSMUSP00000135654.2; ENSMUSG00000024913.17.
DR   UCSC; uc008fwr.2; mouse.
DR   AGR; MGI:1278315; -.
DR   MGI; MGI:1278315; Lrp5.
DR   VEuPathDB; HostDB:ENSMUSG00000024913; -.
DR   GeneTree; ENSGT00940000156574; -.
DR   HOGENOM; CLU_008163_0_3_1; -.
DR   ChiTaRS; Lrp5; mouse.
DR   Proteomes; UP000000589; Chromosome 19.
DR   Bgee; ENSMUSG00000024913; Expressed in epithelium of urethra and 166 other cell types or tissues.
DR   ExpressionAtlas; H3BL52; baseline and differential.
DR   Gene3D; 2.10.25.10; Laminin; 1.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   PANTHER; PTHR46513:SF16; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5; 1.
DR   PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR   Pfam; PF14670; FXa_inhibition; 1.
DR   Pfam; PF00058; Ldl_recept_b; 7.
DR   SMART; SM00135; LY; 10.
DR   SUPFAM; SSF57196; EGF/Laminin; 1.
DR   SUPFAM; SSF63825; YWTD domain; 2.
DR   PROSITE; PS51120; LDLRB; 8.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|MaxQB:H3BL52,
KW   ECO:0007829|ProteomicsDB:H3BL52};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           31..618
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003580943"
FT   REPEAT          74..118
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          119..161
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          162..205
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          206..248
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          384..426
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          427..469
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          470..513
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          514..556
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
SQ   SEQUENCE   618 AA;  69491 MW;  986B802F95C7ABA9 CRC64;
     METAPTRAPP PPPPPLLLLV LYCSLVPAAA SPLLLFANRR DVRLVDAGGV KLESTIVASG
     LEDAAAVDFQ FSKGAVYWTD VSEEAIKQTY LNQTGAAAQN IVISGLVSPD GLACDWVGKK
     LYWTDSETNR IEVANLNGTS RKVLFWQDLD QPRAIALDPA HGYMYWTDWG EAPRIERAGM
     DGSTRKIIVD SDIYWPNGLT IDLEEQKLYW ADAKLSFIHR ANLDGSFRQK VVEGSLTHPF
     ALTLSGDTLY WTDWQTRSIH ACNKWTGEQR KEILSALYSP MDIQVLSQER QPPFHTPCEE
     DNGGCSHLCL LSPREPFYSC ACPTGVQLQD NGKTCKTGAE EVLLLARRTD LRRISLDTPD
     FTDIVLQVGD IRHAIAIDYD PLEGYVYWTD DEVRAIRRAY LDGSGAQTLV NTEINDPDGI
     AVDWVARNLY WTDTGTDRIE VTRLNGTSRK ILVSEDLDEP RAIVLHPVMG LMYWTDWGEN
     PKIECANLDG RDRHVLVNTS LGWPNGLALD LQEGKLYWGD AKTDKIEVIN IDGTKRKTLL
     EDKLPHIFGF TLLGDFIYWT DWQRRSIERV HKVKASRDVI IDQLPDLMGL KAVNVAKVVG
     ESWSSEPWLH LASWPQER
//