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H3BL52 (H3BL52_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Lrp5 Ensembl ENSMUSP00000135654 MGI 1278315
OrganismMus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000135654
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length618 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000135654

Ontologies

Keywords
   Cellular componentMembrane
   DomainEGF-like domain SAAS SAAS011042
Repeat SAAS SAAS011042
Transmembrane
Transmembrane helix SAAS SAAS000033
   PTMDisulfide bond SAAS SAAS011042
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from direct assay PubMed 11956231. Source: MGI

Wnt signaling pathway involved in dorsal/ventral axis specification

Inferred from Biological aspect of Ancestor. Source: RefGenome

adipose tissue development

Inferred from Biological aspect of Ancestor. Source: RefGenome

anatomical structure regression

Inferred from mutant phenotype PubMed 16163358. Source: MGI

anterior/posterior pattern specification

Inferred from genetic interaction PubMed 15142971. Source: MGI

apoptotic process involved in patterning of blood vessels

Inferred from mutant phenotype PubMed 16163358. Source: MGI

bone marrow development

Inferred from Biological aspect of Ancestor. Source: RefGenome

bone morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

bone remodeling

Inferred from mutant phenotype PubMed 11956231PubMed 15207752PubMed 16790443PubMed 17147489PubMed 17627087. Source: MGI

branching involved in mammary gland duct morphogenesis

Inferred from mutant phenotype PubMed 16973609. Source: MGI

canonical Wnt signaling pathway

Inferred from direct assay PubMed 15143170. Source: MGI

cell migration involved in gastrulation

Inferred from genetic interaction PubMed 15142971. Source: MGI

cell-cell signaling involved in mammary gland development

Inferred from mutant phenotype PubMed 16973609. Source: MGI

cholesterol homeostasis

Inferred from Biological aspect of Ancestor. Source: RefGenome

cholesterol metabolic process

Inferred from mutant phenotype PubMed 12509515. Source: MGI

embryonic camera-type eye morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

embryonic digit morphogenesis

Inferred from genetic interaction PubMed 15142971. Source: MGI

embryonic retina morphogenesis in camera-type eye

Inferred from Biological aspect of Ancestor. Source: RefGenome

gastrulation with mouth forming second

Inferred from genetic interaction PubMed 15142971. Source: MGI

limb morphogenesis

Inferred from genetic interaction PubMed 15537447. Source: MGI

mammary gland duct morphogenesis

Inferred from genetic interaction PubMed 19503830. Source: MGI

osteoblast development

Inferred from mutant phenotype PubMed 16790443. Source: MGI

positive regulation of osteoblast proliferation

Inferred from mutant phenotype PubMed 11956231. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of apoptotic process

Inferred from mutant phenotype PubMed 11956231. Source: MGI

regulation of bone remodeling

Inferred from mutant phenotype PubMed 12817748. Source: MGI

regulation of fat cell differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of insulin secretion involved in cellular response to glucose stimulus

Inferred from mutant phenotype PubMed 12509515. Source: MGI

regulation of ossification

Inferred from Biological aspect of Ancestor. Source: RefGenome

retina vasculature morphogenesis in camera-type eye

Inferred from mutant phenotype PubMed 11956231PubMed 18263894. Source: MGI

retinal blood vessel morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

somatic stem cell maintenance

Inferred from mutant phenotype PubMed 19672307. Source: MGI

vasculature development

Inferred from mutant phenotype PubMed 16163358. Source: MGI

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrion

Inferred from direct assay PubMed 14651853. Source: MGI

plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

receptor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionWnt-activated receptor activity

Inferred from direct assay PubMed 11956231. Source: MGI

Wnt-protein binding

Inferred from physical interaction PubMed 11956231. Source: MGI

coreceptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein binding

Inferred from physical interaction PubMed 18632848PubMed 19075000. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
H3BL52 [UniParc].

Last modified April 18, 2012. Version 1.
Checksum: 986B802F95C7ABA9

FASTA61869,491
        10         20         30         40         50         60 
METAPTRAPP PPPPPLLLLV LYCSLVPAAA SPLLLFANRR DVRLVDAGGV KLESTIVASG 

        70         80         90        100        110        120 
LEDAAAVDFQ FSKGAVYWTD VSEEAIKQTY LNQTGAAAQN IVISGLVSPD GLACDWVGKK 

       130        140        150        160        170        180 
LYWTDSETNR IEVANLNGTS RKVLFWQDLD QPRAIALDPA HGYMYWTDWG EAPRIERAGM 

       190        200        210        220        230        240 
DGSTRKIIVD SDIYWPNGLT IDLEEQKLYW ADAKLSFIHR ANLDGSFRQK VVEGSLTHPF 

       250        260        270        280        290        300 
ALTLSGDTLY WTDWQTRSIH ACNKWTGEQR KEILSALYSP MDIQVLSQER QPPFHTPCEE 

       310        320        330        340        350        360 
DNGGCSHLCL LSPREPFYSC ACPTGVQLQD NGKTCKTGAE EVLLLARRTD LRRISLDTPD 

       370        380        390        400        410        420 
FTDIVLQVGD IRHAIAIDYD PLEGYVYWTD DEVRAIRRAY LDGSGAQTLV NTEINDPDGI 

       430        440        450        460        470        480 
AVDWVARNLY WTDTGTDRIE VTRLNGTSRK ILVSEDLDEP RAIVLHPVMG LMYWTDWGEN 

       490        500        510        520        530        540 
PKIECANLDG RDRHVLVNTS LGWPNGLALD LQEGKLYWGD AKTDKIEVIN IDGTKRKTLL 

       550        560        570        580        590        600 
EDKLPHIFGF TLLGDFIYWT DWQRRSIERV HKVKASRDVI IDQLPDLMGL KAVNVAKVVG 

       610 
ESWSSEPWLH LASWPQER 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC112990 Genomic DNA. No translation available.
AC117797 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalH3BL52.
SMRH3BL52. Positions 31-606.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000176867; ENSMUSP00000135654; ENSMUSG00000024913.

Organism-specific databases

MGIMGI:1278315. Lrp5.

Phylogenomic databases

GeneTreeENSGT00750000117273.

Gene expression databases

ArrayExpressH3BL52.
BgeeH3BL52.

Family and domain databases

Gene3D2.120.10.30. 2 hits.
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR000033. LDLR_classB_rpt.
[Graphical view]
PfamPF00058. Ldl_recept_b. 7 hits.
[Graphical view]
SMARTSM00181. EGF. 1 hit.
SM00135. LY. 10 hits.
[Graphical view]
PROSITEPS51120. LDLRB. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio35562022.
SOURCESearch...

Entry information

Entry nameH3BL52_MOUSE
AccessionPrimary (citable) accession number: H3BL52
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: July 9, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)