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H3BL52

- H3BL52_MOUSE

UniProt

H3BL52 - H3BL52_MOUSE

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Protein
Submitted name:

Low-density lipoprotein receptor-related protein 5

Gene
Lrp5
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. coreceptor activity Source: RefGenome
  2. protein binding Source: MGI
  3. Wnt-activated receptor activity Source: MGI
  4. Wnt-protein binding Source: MGI

GO - Biological processi

  1. adipose tissue development Source: RefGenome
  2. anatomical structure regression Source: MGI
  3. anterior/posterior pattern specification Source: MGI
  4. apoptotic process involved in patterning of blood vessels Source: MGI
  5. bone marrow development Source: RefGenome
  6. bone morphogenesis Source: RefGenome
  7. bone remodeling Source: MGI
  8. branching involved in mammary gland duct morphogenesis Source: MGI
  9. canonical Wnt signaling pathway Source: MGI
  10. cell-cell signaling involved in mammary gland development Source: MGI
  11. cell migration involved in gastrulation Source: MGI
  12. cholesterol homeostasis Source: RefGenome
  13. cholesterol metabolic process Source: MGI
  14. embryonic camera-type eye morphogenesis Source: RefGenome
  15. embryonic digit morphogenesis Source: MGI
  16. embryonic retina morphogenesis in camera-type eye Source: RefGenome
  17. gastrulation with mouth forming second Source: MGI
  18. limb morphogenesis Source: MGI
  19. mammary gland duct morphogenesis Source: MGI
  20. osteoblast development Source: MGI
  21. positive regulation of osteoblast proliferation Source: MGI
  22. positive regulation of transcription from RNA polymerase II promoter Source: RefGenome
  23. regulation of apoptotic process Source: MGI
  24. regulation of bone remodeling Source: MGI
  25. regulation of fat cell differentiation Source: RefGenome
  26. regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
  27. regulation of ossification Source: RefGenome
  28. retinal blood vessel morphogenesis Source: RefGenome
  29. retina vasculature morphogenesis in camera-type eye Source: MGI
  30. somatic stem cell maintenance Source: MGI
  31. vasculature development Source: MGI
  32. Wnt signaling pathway Source: MGI
  33. Wnt signaling pathway involved in dorsal/ventral axis specification Source: RefGenome
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Low-density lipoprotein receptor-related protein 5Imported
Gene namesi
Name:Lrp5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1278315. Lrp5.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: MGI
  3. plasma membrane Source: RefGenome
  4. receptor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiH3BL52.
BgeeiH3BL52.

Structurei

3D structure databases

ProteinModelPortaliH3BL52.
SMRiH3BL52. Positions 31-606.

Family & Domainsi

Keywords - Domaini

EGF-like domainSAAS annotations, RepeatSAAS annotations, Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117273.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR000033. LDLR_classB_rpt.
[Graphical view]
PfamiPF00058. Ldl_recept_b. 7 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00135. LY. 10 hits.
[Graphical view]
PROSITEiPS51120. LDLRB. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H3BL52-1 [UniParc]FASTAAdd to Basket

« Hide

METAPTRAPP PPPPPLLLLV LYCSLVPAAA SPLLLFANRR DVRLVDAGGV    50
KLESTIVASG LEDAAAVDFQ FSKGAVYWTD VSEEAIKQTY LNQTGAAAQN 100
IVISGLVSPD GLACDWVGKK LYWTDSETNR IEVANLNGTS RKVLFWQDLD 150
QPRAIALDPA HGYMYWTDWG EAPRIERAGM DGSTRKIIVD SDIYWPNGLT 200
IDLEEQKLYW ADAKLSFIHR ANLDGSFRQK VVEGSLTHPF ALTLSGDTLY 250
WTDWQTRSIH ACNKWTGEQR KEILSALYSP MDIQVLSQER QPPFHTPCEE 300
DNGGCSHLCL LSPREPFYSC ACPTGVQLQD NGKTCKTGAE EVLLLARRTD 350
LRRISLDTPD FTDIVLQVGD IRHAIAIDYD PLEGYVYWTD DEVRAIRRAY 400
LDGSGAQTLV NTEINDPDGI AVDWVARNLY WTDTGTDRIE VTRLNGTSRK 450
ILVSEDLDEP RAIVLHPVMG LMYWTDWGEN PKIECANLDG RDRHVLVNTS 500
LGWPNGLALD LQEGKLYWGD AKTDKIEVIN IDGTKRKTLL EDKLPHIFGF 550
TLLGDFIYWT DWQRRSIERV HKVKASRDVI IDQLPDLMGL KAVNVAKVVG 600
ESWSSEPWLH LASWPQER 618
Length:618
Mass (Da):69,491
Last modified:April 18, 2012 - v1
Checksum:i986B802F95C7ABA9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC112990 Genomic DNA. No translation available.
AC117797 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000176867; ENSMUSP00000135654; ENSMUSG00000024913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC112990 Genomic DNA. No translation available.
AC117797 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali H3BL52.
SMRi H3BL52. Positions 31-606.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000176867 ; ENSMUSP00000135654 ; ENSMUSG00000024913 .

Organism-specific databases

MGIi MGI:1278315. Lrp5.

Phylogenomic databases

GeneTreei ENSGT00750000117273.

Miscellaneous databases

NextBioi 35562022.
SOURCEi Search...

Gene expression databases

ArrayExpressi H3BL52.
Bgeei H3BL52.

Family and domain databases

Gene3Di 2.120.10.30. 2 hits.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR000033. LDLR_classB_rpt.
[Graphical view ]
Pfami PF00058. Ldl_recept_b. 7 hits.
[Graphical view ]
SMARTi SM00181. EGF. 1 hit.
SM00135. LY. 10 hits.
[Graphical view ]
PROSITEi PS51120. LDLRB. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiH3BL52_MOUSE
AccessioniPrimary (citable) accession number: H3BL52
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: July 9, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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