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Protein
Submitted name:

Low-density lipoprotein receptor-related protein 5

Gene

Lrp5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Low-density lipoprotein receptor-related protein 5Imported
Gene namesi
Name:Lrp5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1278315. Lrp5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_500358094331 – 618Sequence analysisAdd BLAST588

Proteomic databases

MaxQBiH3BL52.
PaxDbiH3BL52.
PRIDEiH3BL52.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024913.
ExpressionAtlasiH3BL52. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliH3BL52.
SMRiH3BL52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati74 – 118LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati119 – 161LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati162 – 205LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati206 – 248LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati249 – 289LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati384 – 426LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati427 – 469LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati470 – 513LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati514 – 556LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati557 – 599LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410KD0T. Eukaryota.
ENOG4111JJ7. LUCA.
GeneTreeiENSGT00760000118968.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
InterProiView protein in InterPro
IPR011042. 6-blade_b-propeller_TolB-like.
IPR000033. LDLR_classB_rpt.
PfamiView protein in Pfam
PF00058. Ldl_recept_b. 7 hits.
SMARTiView protein in SMART
SM00135. LY. 10 hits.
PROSITEiView protein in PROSITE
PS51120. LDLRB. 10 hits.

Sequencei

Sequence statusi: Complete.

H3BL52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METAPTRAPP PPPPPLLLLV LYCSLVPAAA SPLLLFANRR DVRLVDAGGV
60 70 80 90 100
KLESTIVASG LEDAAAVDFQ FSKGAVYWTD VSEEAIKQTY LNQTGAAAQN
110 120 130 140 150
IVISGLVSPD GLACDWVGKK LYWTDSETNR IEVANLNGTS RKVLFWQDLD
160 170 180 190 200
QPRAIALDPA HGYMYWTDWG EAPRIERAGM DGSTRKIIVD SDIYWPNGLT
210 220 230 240 250
IDLEEQKLYW ADAKLSFIHR ANLDGSFRQK VVEGSLTHPF ALTLSGDTLY
260 270 280 290 300
WTDWQTRSIH ACNKWTGEQR KEILSALYSP MDIQVLSQER QPPFHTPCEE
310 320 330 340 350
DNGGCSHLCL LSPREPFYSC ACPTGVQLQD NGKTCKTGAE EVLLLARRTD
360 370 380 390 400
LRRISLDTPD FTDIVLQVGD IRHAIAIDYD PLEGYVYWTD DEVRAIRRAY
410 420 430 440 450
LDGSGAQTLV NTEINDPDGI AVDWVARNLY WTDTGTDRIE VTRLNGTSRK
460 470 480 490 500
ILVSEDLDEP RAIVLHPVMG LMYWTDWGEN PKIECANLDG RDRHVLVNTS
510 520 530 540 550
LGWPNGLALD LQEGKLYWGD AKTDKIEVIN IDGTKRKTLL EDKLPHIFGF
560 570 580 590 600
TLLGDFIYWT DWQRRSIERV HKVKASRDVI IDQLPDLMGL KAVNVAKVVG
610
ESWSSEPWLH LASWPQER
Length:618
Mass (Da):69,491
Last modified:April 18, 2012 - v1
Checksum:i986B802F95C7ABA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112990 Genomic DNA. No translation available.
AC117797 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000176867; ENSMUSP00000135654; ENSMUSG00000024913.
UCSCiuc008fwr.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiH3BL52_MOUSE
AccessioniPrimary (citable) accession number: H3BL52
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: August 30, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported