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Protein
Submitted name:

Low-density lipoprotein receptor-related protein 5

Gene

Lrp5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • Wnt-activated receptor activity Source: MGI
  • Wnt-protein binding Source: MGI

GO - Biological processi

  • adipose tissue development Source: MGI
  • anatomical structure regression Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • apoptotic process involved in patterning of blood vessels Source: MGI
  • bone marrow development Source: MGI
  • bone morphogenesis Source: MGI
  • bone remodeling Source: MGI
  • branching involved in mammary gland duct morphogenesis Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cell-cell signaling involved in mammary gland development Source: MGI
  • cell migration involved in gastrulation Source: MGI
  • cholesterol homeostasis Source: MGI
  • cholesterol metabolic process Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • gastrulation with mouth forming second Source: MGI
  • glucose catabolic process Source: MGI
  • limb morphogenesis Source: MGI
  • mammary gland duct morphogenesis Source: MGI
  • negative regulation of osteoblast differentiation Source: MGI
  • negative regulation of protein serine/threonine kinase activity Source: MGI
  • osteoblast development Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of fat cell differentiation Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • positive regulation of mitotic nuclear division Source: MGI
  • positive regulation of osteoblast proliferation Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of apoptotic process Source: MGI
  • regulation of blood pressure Source: MGI
  • regulation of bone remodeling Source: MGI
  • regulation of canonical Wnt signaling pathway Source: MGI
  • regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
  • retinal blood vessel morphogenesis Source: MGI
  • retina morphogenesis in camera-type eye Source: MGI
  • retina vasculature morphogenesis in camera-type eye Source: MGI
  • somatic stem cell maintenance Source: MGI
  • vasculature development Source: MGI
  • Wnt signaling pathway Source: MGI
  • Wnt signaling pathway involved in dorsal/ventral axis specification Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Low-density lipoprotein receptor-related protein 5Imported
Gene namesi
Name:Lrp5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1278315. Lrp5.

Subcellular locationi

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: MGI
  • plasma membrane Source: MGI
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiH3BL52.
ExpressionAtlasiH3BL52. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025856.

Structurei

3D structure databases

ProteinModelPortaliH3BL52.
SMRiH3BL52. Positions 31-606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118968.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR000033. LDLR_classB_rpt.
[Graphical view]
PfamiPF00058. Ldl_recept_b. 7 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00135. LY. 10 hits.
[Graphical view]
PROSITEiPS51120. LDLRB. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H3BL52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METAPTRAPP PPPPPLLLLV LYCSLVPAAA SPLLLFANRR DVRLVDAGGV
60 70 80 90 100
KLESTIVASG LEDAAAVDFQ FSKGAVYWTD VSEEAIKQTY LNQTGAAAQN
110 120 130 140 150
IVISGLVSPD GLACDWVGKK LYWTDSETNR IEVANLNGTS RKVLFWQDLD
160 170 180 190 200
QPRAIALDPA HGYMYWTDWG EAPRIERAGM DGSTRKIIVD SDIYWPNGLT
210 220 230 240 250
IDLEEQKLYW ADAKLSFIHR ANLDGSFRQK VVEGSLTHPF ALTLSGDTLY
260 270 280 290 300
WTDWQTRSIH ACNKWTGEQR KEILSALYSP MDIQVLSQER QPPFHTPCEE
310 320 330 340 350
DNGGCSHLCL LSPREPFYSC ACPTGVQLQD NGKTCKTGAE EVLLLARRTD
360 370 380 390 400
LRRISLDTPD FTDIVLQVGD IRHAIAIDYD PLEGYVYWTD DEVRAIRRAY
410 420 430 440 450
LDGSGAQTLV NTEINDPDGI AVDWVARNLY WTDTGTDRIE VTRLNGTSRK
460 470 480 490 500
ILVSEDLDEP RAIVLHPVMG LMYWTDWGEN PKIECANLDG RDRHVLVNTS
510 520 530 540 550
LGWPNGLALD LQEGKLYWGD AKTDKIEVIN IDGTKRKTLL EDKLPHIFGF
560 570 580 590 600
TLLGDFIYWT DWQRRSIERV HKVKASRDVI IDQLPDLMGL KAVNVAKVVG
610
ESWSSEPWLH LASWPQER
Length:618
Mass (Da):69,491
Last modified:April 18, 2012 - v1
Checksum:i986B802F95C7ABA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112990 Genomic DNA. No translation available.
AC117797 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000176867; ENSMUSP00000135654; ENSMUSG00000024913.
UCSCiuc008fwr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112990 Genomic DNA. No translation available.
AC117797 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliH3BL52.
SMRiH3BL52. Positions 31-606.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000176867; ENSMUSP00000135654; ENSMUSG00000024913.
UCSCiuc008fwr.2. mouse.

Organism-specific databases

MGIiMGI:1278315. Lrp5.

Phylogenomic databases

GeneTreeiENSGT00760000118968.

Miscellaneous databases

NextBioi35562022.
SOURCEiSearch...

Gene expression databases

BgeeiH3BL52.
ExpressionAtlasiH3BL52. baseline and differential.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR000033. LDLR_classB_rpt.
[Graphical view]
PfamiPF00058. Ldl_recept_b. 7 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00135. LY. 10 hits.
[Graphical view]
PROSITEiPS51120. LDLRB. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiH3BL52_MOUSE
AccessioniPrimary (citable) accession number: H3BL52
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: July 22, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.