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H3BL52

- H3BL52_MOUSE

UniProt

H3BL52 - H3BL52_MOUSE

Protein
Submitted name:

Low-density lipoprotein receptor-related protein 5

Gene

Lrp5

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. coreceptor activity Source: RefGenome
    2. protein binding Source: MGI
    3. Wnt-activated receptor activity Source: MGI
    4. Wnt-protein binding Source: MGI

    GO - Biological processi

    1. adipose tissue development Source: RefGenome
    2. anatomical structure regression Source: MGI
    3. anterior/posterior pattern specification Source: MGI
    4. apoptotic process involved in patterning of blood vessels Source: MGI
    5. bone marrow development Source: RefGenome
    6. bone morphogenesis Source: RefGenome
    7. bone remodeling Source: MGI
    8. branching involved in mammary gland duct morphogenesis Source: MGI
    9. canonical Wnt signaling pathway Source: MGI
    10. cell-cell signaling involved in mammary gland development Source: MGI
    11. cell migration involved in gastrulation Source: MGI
    12. cholesterol homeostasis Source: RefGenome
    13. cholesterol metabolic process Source: MGI
    14. embryonic camera-type eye morphogenesis Source: RefGenome
    15. embryonic digit morphogenesis Source: MGI
    16. embryonic retina morphogenesis in camera-type eye Source: RefGenome
    17. gastrulation with mouth forming second Source: MGI
    18. limb morphogenesis Source: MGI
    19. mammary gland duct morphogenesis Source: MGI
    20. osteoblast development Source: MGI
    21. positive regulation of osteoblast proliferation Source: MGI
    22. positive regulation of transcription from RNA polymerase II promoter Source: RefGenome
    23. regulation of apoptotic process Source: MGI
    24. regulation of bone remodeling Source: MGI
    25. regulation of fat cell differentiation Source: RefGenome
    26. regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
    27. regulation of ossification Source: RefGenome
    28. retinal blood vessel morphogenesis Source: RefGenome
    29. retina vasculature morphogenesis in camera-type eye Source: MGI
    30. somatic stem cell maintenance Source: MGI
    31. vasculature development Source: MGI
    32. Wnt signaling pathway Source: MGI
    33. Wnt signaling pathway involved in dorsal/ventral axis specification Source: RefGenome

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Low-density lipoprotein receptor-related protein 5Imported
    Gene namesi
    Name:Lrp5Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1278315. Lrp5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrion Source: MGI
    3. plasma membrane Source: RefGenome
    4. receptor complex Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiH3BL52.
    BgeeiH3BL52.

    Structurei

    3D structure databases

    ProteinModelPortaliH3BL52.
    SMRiH3BL52. Positions 31-606.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    EGF-like domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117273.

    Family and domain databases

    Gene3Di2.120.10.30. 2 hits.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR000742. EG-like_dom.
    IPR000033. LDLR_classB_rpt.
    [Graphical view]
    PfamiPF00058. Ldl_recept_b. 7 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 1 hit.
    SM00135. LY. 10 hits.
    [Graphical view]
    PROSITEiPS51120. LDLRB. 10 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H3BL52-1 [UniParc]FASTAAdd to Basket

    « Hide

    METAPTRAPP PPPPPLLLLV LYCSLVPAAA SPLLLFANRR DVRLVDAGGV    50
    KLESTIVASG LEDAAAVDFQ FSKGAVYWTD VSEEAIKQTY LNQTGAAAQN 100
    IVISGLVSPD GLACDWVGKK LYWTDSETNR IEVANLNGTS RKVLFWQDLD 150
    QPRAIALDPA HGYMYWTDWG EAPRIERAGM DGSTRKIIVD SDIYWPNGLT 200
    IDLEEQKLYW ADAKLSFIHR ANLDGSFRQK VVEGSLTHPF ALTLSGDTLY 250
    WTDWQTRSIH ACNKWTGEQR KEILSALYSP MDIQVLSQER QPPFHTPCEE 300
    DNGGCSHLCL LSPREPFYSC ACPTGVQLQD NGKTCKTGAE EVLLLARRTD 350
    LRRISLDTPD FTDIVLQVGD IRHAIAIDYD PLEGYVYWTD DEVRAIRRAY 400
    LDGSGAQTLV NTEINDPDGI AVDWVARNLY WTDTGTDRIE VTRLNGTSRK 450
    ILVSEDLDEP RAIVLHPVMG LMYWTDWGEN PKIECANLDG RDRHVLVNTS 500
    LGWPNGLALD LQEGKLYWGD AKTDKIEVIN IDGTKRKTLL EDKLPHIFGF 550
    TLLGDFIYWT DWQRRSIERV HKVKASRDVI IDQLPDLMGL KAVNVAKVVG 600
    ESWSSEPWLH LASWPQER 618
    Length:618
    Mass (Da):69,491
    Last modified:April 18, 2012 - v1
    Checksum:i986B802F95C7ABA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC112990 Genomic DNA. No translation available.
    AC117797 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000176867; ENSMUSP00000135654; ENSMUSG00000024913.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC112990 Genomic DNA. No translation available.
    AC117797 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali H3BL52.
    SMRi H3BL52. Positions 31-606.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000176867 ; ENSMUSP00000135654 ; ENSMUSG00000024913 .

    Organism-specific databases

    MGIi MGI:1278315. Lrp5.

    Phylogenomic databases

    GeneTreei ENSGT00750000117273.

    Miscellaneous databases

    NextBioi 35562022.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi H3BL52.
    Bgeei H3BL52.

    Family and domain databases

    Gene3Di 2.120.10.30. 2 hits.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR000742. EG-like_dom.
    IPR000033. LDLR_classB_rpt.
    [Graphical view ]
    Pfami PF00058. Ldl_recept_b. 7 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 1 hit.
    SM00135. LY. 10 hits.
    [Graphical view ]
    PROSITEi PS51120. LDLRB. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiH3BL52_MOUSE
    AccessioniPrimary (citable) accession number: H3BL52
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2012
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3