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Protein

Phosphoinositide phospholipase C

Gene

Plch1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, TransducerSAAS annotation

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:Plch1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2683547. Plch1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiH3BKK4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036834.
ExpressionAtlasiH3BKK4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081122.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 140109PHInterPro annotationAdd
BLAST
Domaini154 – 18936EF-handInterPro annotationAdd
BLAST
Domaini190 – 22637EF-handInterPro annotationAdd
BLAST
Domaini238 – 25821EF-handInterPro annotationAdd
BLAST
Domaini311 – 456146PI-PLC X-boxInterPro annotationAdd
BLAST
Domaini613 – 725113PI-PLC Y-boxInterPro annotationAdd
BLAST
Domaini731 – 838108C2InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PH domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation
Contains 3 EF-hand domains.UniRule annotation

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
GeneTreeiENSGT00760000118936.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR028392. PLC-eta1.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 3 hits.
PTHR10336:SF51. PTHR10336:SF51. 3 hits.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H3BKK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYWNGEKRN CVQYRRHFLV DNRVFHVERC MSVMQSGTQM IKLKRGTKGL
60 70 80 90 100
VRLFYLDEHR TRLRWRPSRK SEKAKILIDS IYKVTEGRQS EIFHRQAEGN
110 120 130 140 150
FDPSCCFTIY HGNHMESLDL ITSNPEEART WITGLKYLMA GISDEDSLAK
160 170 180 190 200
RQRTHDQWVK QTFEEADKNG DGLLNIEEIH QLMHKLNVNL PRRKVRQMFQ
210 220 230 240 250
EADTDENQGT LTFEEFCVFY KMMSLRRDLY LLLLSYSDKK DHLTVEELAQ
260 270 280 290 300
FLKVEQKMSN VTLDYCLDII MKFEVSEENK VKNVLGIEGF TNFMRSPACD
310 320 330 340 350
VFNPLHHEVY QDMDQPLCNY YIASSHNTYL TGDQLLSQSK VDMYARVLQE
360 370 380 390 400
GCRCVEVDCW DGPDGEPVVH HGYTLTSKIL FRDVVETINK HAFVKNEFPV
410 420 430 440 450
ILSIENHCSI QQQRKIAQYL KGILQDKLDL SSVDTGECRQ LPSPQSLKGK
460 470 480 490 500
ILVKGKKLPY HLGDDAEEGE VSDEDSADEI EDECKFKLHY SNGTTEHQVE
510 520 530 540 550
SFIRKKLESL LKESQIRDKE DPDSFTVRAL LKATHEGLNA HLKQNLDVKE
560 570 580 590 600
SGKKSHGRSL MANFGKHKKA TKSRSKSYST DDEDDSLQNP GKEGGQLYRL
610 620 630 640 650
GRRRRTMKLC RELSDLVVYT NSVAAQDIVD DGTTGNVLSF SETRAHQVVQ
660 670 680 690 700
QKSEQFMIYN QKQLTRIYPS AYRIDSSNFN PLPYWNAGCQ LVALNYQSEG
710 720 730 740 750
RMMQINRAKF KANGNCGYIL KPQQMCKGTF NPFSGDPLPA NPKKQLILKV
760 770 780 790 800
ISGQQLPKPP DSMFGDRGEI IDPFVEVEII GLPVDCCKDQ TRVVDDNGFN
810 820 830 840 850
PVWEETLTFT VHMPEIALVR FLVWDHDPIG RDFVGQRTVT FSSLVPGYRH
860 870 880 890 900
VYLEGLTEAS IFVHITINEI FGKNRQLQGL KGLFNKNPRH ASSENNSHYV
910 920 930 940 950
RKRSIGDRIL RRTASAPAKG RKKSKVGFQE MVEIKDSVSE ASRDQDGVLR
960 970 980 990 1000
RTTRSLQVRP VSMPVDKSLL GALSLPISEA AKDTDGKENC LAGDKDDRRK
1010 1020 1030 1040 1050
GAATRKDPHF SNFNKKLSSS SSALLHKDAN QGPTASVSNP EQCGGRGAKS
1060 1070 1080 1090 1100
ERIKPNMTND CQENHNPPKF LSPRKHLALD PATKGLQERL HGMKTNEKEH
1110 1120 1130 1140 1150
AEGFLGEKSM LSGSVLSQSS LEVENLEGSR AKGRAATSFS LSDVSALCSD
1160 1170 1180 1190 1200
IPDLHSTAIL QDTEISNLID DVTLTNENQS GSSISALIGQ FEESNHPANV
1210 1220 1230 1240 1250
TVVSHLSTSG ASGSAPFQTP FKHGLSQGNQ KASFLCSSPE LNKLSSVETT
1260 1270 1280 1290 1300
KLANNAVPCG VIGSPISTPK PGDDPSDKAK TRVIEGNLPG FPDASPGQFP
1310 1320 1330 1340 1350
KSPTHGEDHS QVMNSPALST ELAIEDIIAD PALSINSAES SLVEIDGESE
1360 1370 1380 1390 1400
NLSLTTCDYR EEAPSQLVSP LKLQQSQEMV EHIQRGLRNG YCKETLLPSE
1410 1420 1430 1440 1450
IFNNIPGVKN HSISHLTYQG AGFVYNHFSS SDAKTNQICE PQQPRAPDMH
1460 1470 1480 1490 1500
APTPTPSTHA PLAALKLPSP CKSKSLGDLT SEDIACNFES KYQCISRSFV
1510 1520 1530 1540 1550
TNGIRDKSVT MKTKSLEPLD ALTEQLRKLV SFDQEDSCQV LYSKQDVNQC
1560 1570 1580 1590 1600
PRALVRKLSS RSQSRVRNIA SRAKEKQEAG KQKAMAQSTR GGVVLRSKPP
1610 1620 1630 1640 1650
APALAVNRHS TGSYIASYLR NMKAGGLEGR GIPEGACTAL RYGYMDQFCS
1660 1670
DNSVLQTEPS SEDKPEIYFL LRL
Length:1,673
Mass (Da):187,107
Last modified:April 18, 2012 - v1
Checksum:i24B24B95611BA35A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116732 Genomic DNA. No translation available.
AC121285 Genomic DNA. No translation available.
RefSeqiXP_006501601.1. XM_006501538.2.
UniGeneiMm.316391.
Mm.488521.

Genome annotation databases

EnsembliENSMUST00000177143; ENSMUSP00000135424; ENSMUSG00000036834.
GeneIDi269437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116732 Genomic DNA. No translation available.
AC121285 Genomic DNA. No translation available.
RefSeqiXP_006501601.1. XM_006501538.2.
UniGeneiMm.316391.
Mm.488521.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081122.

Proteomic databases

PaxDbiH3BKK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000177143; ENSMUSP00000135424; ENSMUSG00000036834.
GeneIDi269437.

Organism-specific databases

CTDi23007.
MGIiMGI:2683547. Plch1.

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
GeneTreeiENSGT00760000118936.

Miscellaneous databases

ChiTaRSiPlch1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036834.
ExpressionAtlasiH3BKK4. baseline and differential.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR028392. PLC-eta1.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 3 hits.
PTHR10336:SF51. PTHR10336:SF51. 3 hits.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH3BKK4_MOUSE
AccessioniPrimary (citable) accession number: H3BKK4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 7, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.