ID   H3BJH0_MOUSE            Unreviewed;       279 AA.
AC   H3BJH0;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   SubName: Full=Low density lipoprotein receptor-related protein 5 {ECO:0000313|Ensembl:ENSMUSP00000134983.2};
GN   Name=Lrp5 {ECO:0000313|Ensembl:ENSMUSP00000134983.2,
GN   ECO:0000313|MGI:MGI:1278315};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000134983.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000134983.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134983.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000134983.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134983.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; H3BJH0; -.
DR   SMR; H3BJH0; -.
DR   MaxQB; H3BJH0; -.
DR   PeptideAtlas; H3BJH0; -.
DR   ProteomicsDB; 325054; -.
DR   Antibodypedia; 4572; 486 antibodies from 37 providers.
DR   Ensembl; ENSMUST00000177330.8; ENSMUSP00000134983.2; ENSMUSG00000024913.17.
DR   AGR; MGI:1278315; -.
DR   MGI; MGI:1278315; Lrp5.
DR   VEuPathDB; HostDB:ENSMUSG00000024913; -.
DR   GeneTree; ENSGT00940000156574; -.
DR   HOGENOM; CLU_997342_0_0_1; -.
DR   ChiTaRS; Lrp5; mouse.
DR   Proteomes; UP000000589; Chromosome 19.
DR   Bgee; ENSMUSG00000024913; Expressed in epithelium of urethra and 166 other cell types or tissues.
DR   ExpressionAtlas; H3BJH0; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   PANTHER; PTHR46513:SF13; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4-LIKE PROTEIN; 1.
DR   PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR   Pfam; PF00058; Ldl_recept_b; 2.
DR   SMART; SM00135; LY; 4.
DR   SUPFAM; SSF63825; YWTD domain; 1.
DR   PROSITE; PS51120; LDLRB; 3.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        16..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REPEAT          74..118
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          119..161
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          162..205
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
SQ   SEQUENCE   279 AA;  30888 MW;  6D1A15C7FAE1DE65 CRC64;
     METAPTRAPP PPPPPLLLLV LYCSLVPAAA SPLLLFANRR DVRLVDAGGV KLESTIVASG
     LEDAAAVDFQ FSKGAVYWTD VSEEAIKQTY LNQTGAAAQN IVISGLVSPD GLACDWVGKK
     LYWTDSETNR IEVANLNGTS RKVLFWQDLD QPRAIALDPA HGYMYWTDWG EAPRIERAGM
     DGSTRKIIVD SDIYWPNGLT IDLEEQKLYW ADAKLSFIHR ANLDGSFRNM LNVPSKLCER
     NIHSLRDGSC ARRALSSIPA GHTIRGRRWW RAASLTLLP
//